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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
DNA Gyrase-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "DNA Gyrase-IN-1" in MCE Product Catalog:
Cat. No.: HY-147000
CAS No.: 3031486-11-7
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DNA Gyrase-IN-1 (compound 42) is a potent and selective DNA gyrase inhibitor with an IC50 value of 2.6 µM. DNA Gyrase-IN-1 has high inhibitory activity against Mycobacterium tuberculosis (Mtb) with MIC of 0.49 µM. DNA Gyrase-IN-1 can be used for researching tuberculosis .
Cat. No.: HY-147778
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14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase. 14α-Demethylase/DNA Gyrase-IN-1 has antimicrobial activities .
Cat. No.: HY-147945
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DNA gyrase B-IN-1 (compound 13) is a potent DNA gyrase B inhibitor. DNA gyrase B-IN-1 shows inhibition of P. aeruginosa DNA gyrase B, with an IC50 of 2.2 μM. DNA gyrase B-IN-1 has good binding affinity and stability .
Cat. No.: HY-149851
CAS No.: 2925308-68-3
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DNA Gyrase-IN-7 (compound 6d) is a novel Microbial DNA-Gyrase inhibitor .
Cat. No.: HY-189061
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Topoisomerase IN-7 is a bacterial topoisomerase inhibitor, with an IC50 value of 47 nM against Staphylococcus aureus DNA gyrase, 85 nM against Escherichia coli DNA gyrase, and 1 nM against Escherichia coli topoisomerase IV. Topoisomerase IN-7 inhibits the supercoiling activity of DNA gyrase, suppresses the relaxation activity of topoisomerase IV, stabilizes single-stranded DNA cleavage complexes, inhibits biofilm formation of specific bacteria, stimulates biofilm formation of methicillin-resistant Staphylococcus aureus, and exhibits bactericidal activity. Topoisomerase IN-7 is selective for bacterial topoisomerases over human topoisomerase IIα, shows moderate cytotoxicity, and inhibits the hERG potassium channel. Topoisomerase IN-7 can be used in studies of bacterial infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
