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Isoforms Recommended: DP
Results for "

DP

" in MedChemExpress (MCE) Product Catalog:

134

Inhibitors & Agonists

3

Fluorescent Dyes

13

Peptides

2

Inhibitory Antibodies

12

Natural
Products

7

Recombinant Proteins

11

Isotope-Labeled Compounds

28

Antibodies

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100441
    Treprostinil
    1 Publications Verification

    UT-15

    Prostaglandin Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil
  • HY-12558
    LY3009120
    Maximum Cited Publications
    14 Publications Verification

    DP-4978

    Raf Autophagy Cancer
    LY3009120 (DP-4978) is a pan RAF inhibitor which inhibits BRAF V600E, BRAF WT and CRAF WT with IC50s of 5.8, 9.1 and 15 nM, respectively.
    LY3009120
  • HY-P0052
    Enfuvirtide
    4 Publications Verification

    T20; DP178

    HIV Infection
    Enfuvirtide (T20;DP178) is an anti-HIV-1 fusion inhibitor peptide.
    Enfuvirtide
  • HY-17449

    CA 4DP; CA 4P; Combretastatin A4 disodium phosphate

    Microtubule/Tubulin Apoptosis Cancer
    Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis .
    Fosbretabulin disodium
  • HY-101987

    Prostaglandin Receptor Cardiovascular Disease Metabolic Disease
    BW 245C is a prostanoid DP-receptor (DP1) agonist, used to study stroke.
    BW 245C
  • HY-136548B

    TFV-DP disodium

    HIV Reverse Transcriptase Infection Inflammation/Immunology
    Tenofovir diphosphate disodium is an antiretroviral agent. Tenofovir diphosphate disodium is an inhibitor of HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). Tenofovir diphosphate disodium can be used for the research of AIDS .
    Tenofovir diphosphate disodium
  • HY-16504
    Treprostinil sodium
    1 Publications Verification

    UT-15 sodium

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil sodium
  • HY-18973
    Dp44mT
    5 Publications Verification

    Apoptosis Ferroptosis Cancer
    Dp44mT is an iron chelator with selective anticancer activity.
    Dp44mT
  • HY-14973

    AMG 853

    Prostaglandin Receptor Inflammation/Immunology
    Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC50s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment .
    Vidupiprant
  • HY-16763
    Asapiprant
    1 Publications Verification

    S-555739

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM.
    Asapiprant
  • HY-113366

    PGJ2

    Prostaglandin Receptor Endogenous Metabolite Neurological Disease
    Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) .
    Prostaglandin J2
  • HY-16751

    APD811

    Prostaglandin Receptor Cardiovascular Disease Endocrinology
    Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
    Ralinepag
  • HY-P3325

    D-P8RI

    VEGFR Inflammation/Immunology
    P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway .
    P8RI
  • HY-114243

    NF-κB JNK Caspase Apoptosis Neurological Disease Cancer
    DpC is a selective, orally active iron chelator with anticancer activity. DpC acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates caspase 3/9 to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .
    DpC
  • HY-50175

    MK-0524

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Laropiprant is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively .
    Laropiprant
  • HY-129143
    Delphinidin-3-sambubioside chloride
    1 Publications Verification

    DP3‐Sam chloride

    Apoptosis Metabolic Disease Inflammation/Immunology
    Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L. .
    Delphinidin-3-sambubioside chloride
  • HY-15342
    Timapiprant
    4 Publications Verification

    OC000459

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant (OC000459) potently displaces [ 3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils .
    Timapiprant
  • HY-136548

    TFV-DP

    Reverse Transcriptase HIV Infection Inflammation/Immunology
    Tenofovir diphosphate is an antiretroviral agent. Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase DNA (Ki = 1.55 μM) and RNA (Ki = 0.022 μM). Tenofovir diphosphate can be used for the research of AIDS .
    Tenofovir diphosphate
  • HY-10418
    AH 6809
    4 Publications Verification

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively. AH 6809 has a Ki of 350 nM for mouse EP2 receptor .
    AH 6809
  • HY-B0584
    Travoprost
    3 Publications Verification

    Fluprostenol isopropyl ester; AL6221; Flu-Ipr

    Prostaglandin Receptor Cardiovascular Disease Endocrinology
    Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .
    Travoprost
  • HY-18971
    TG4-155
    1 Publications Verification

    Prostaglandin Receptor Neurological Disease Inflammation/Immunology Endocrinology Cancer
    TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM . TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 . TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor .
    TG4-155
  • HY-148383

    Indoleamine 2,3-Dioxygenase (IDO) Cancer
    DP00477 is a potent IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor with an IC50 value of 7.0 µM. DP00477 has the potential for the research of cancer .
    DP00477
  • HY-N6836

    Others Others
    Fructo-oligosaccharide DP8/GF7 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=8). Fructo-oligosaccharides (FOS) are composed of 7 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .
    Fructo-oligosaccharide DP8/GF7
  • HY-168936

    PROTACs Epigenetic Reader Domain Apoptosis Cancer
    DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models . (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095))
    DP-15
  • HY-N6835

    Others Others
    Fructo-oligosaccharide DP9/GF8 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=9). Fructo-oligosaccharides (FOS) are composed of 8 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .
    Fructo-oligosaccharide DP9/GF8
  • HY-P0052A
    Enfuvirtide acetate
    4 Publications Verification

    T20 acetate; DP178 acetate

    HIV Infection
    Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide.
    Enfuvirtide acetate
  • HY-15342A
    Timapiprant sodium
    4 Publications Verification

    OC000459 sodium

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [ 3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils .
    Timapiprant sodium
  • HY-132995

    Drug Metabolite Others
    DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity .
    DP-1
  • HY-N6837

    Others Others
    Fructo-oligosaccharide DP7/GF6 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=7). Fructo-oligosaccharides (FOS) are composed of 6 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .
    Fructo-​oligosaccharide DP7/GF6
  • HY-121872

    MMP Neurological Disease
    DP-b99 is a chelator of zinc and calcium ions that acts selectively within cell membranes and has neuroprotective properties in animal models of stroke.
    DP-b99
  • HY-P3386A

    Cpne7-DP acetate

    Calcium Channel Metabolic Disease
    Selcopintide (Cpne7-DP) acetate consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide acetate highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide acetate promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin .
    Selcopintide acetate
  • HY-B2221S4

    Endogenous Metabolite Isotope-Labeled Compounds Others
    U-sup>13C Cellulose high DP from maize (high purity) is the 13C labeled Cellulose .
    U-13C Cellulose high DP from maize (high purity)
  • HY-108319

    Dipeptidyl Peptidase Neurological Disease Inflammation/Immunology
    DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV (DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively.
    DPP-IV-IN-2
  • HY-13213

    AM211 free acid

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
    AM211
  • HY-148190

    CGT-8012

    Dipeptidyl Peptidase Endocrinology
    Sheng Gelieting (CGT-8012) is a dipeptidy peptidase-IV enzyme (DP-IV) inhibitor. Sheng Gelieting has great DP-IV inhibition activity with an IC50 value of 87 nM. Sheng Gelieting can be used for curing or preventing diseases relevant to the dipeptidy peptidase-IV enzyme, such as the diabetes, particularly the II-type diabete .
    Sheng Gelieting
  • HY-114141

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively . BI-671800 has potential for the treatment of poorly controlled asthma .
    BI-671800
  • HY-B0813
    Treprostinil diethanolamine
    1 Publications Verification

    UT-15C

    Prostaglandin Receptor Endocrinology
    Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries .
    Treprostinil diethanolamine
  • HY-P3386

    Cpne7-DP

    Calcium Channel Metabolic Disease
    Selcopintide (Cpne7-DP) consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin .
    Selcopintide
  • HY-111271A

    Prostaglandin Receptor Inflammation/Immunology Endocrinology
    L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.
    L 888607 Racemate
  • HY-125782

    15(R)-15-Methyl PGD2

    Prostaglandin Receptor Metabolic Disease
    15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.
    15(R)​-​15-​Methyl prostaglandin D2
  • HY-101430

    Prostaglandin Receptor Inflammation/Immunology
    PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.
    PGD2-IN-1
  • HY-164018A

    DNA/RNA Synthesis Infection
    PMEG-DP disodium is a potent DNA polymerase inhibitor (IC50=2.5 μM), especially for DNA polymerase α and δ. PMEG-DP disodium acts as an active metabolite of G-9191, which effectively inhibits the growth of papillomavirus (HPV) -infected cell lines. PMEG-DP disodium can be used in the study of HPV-related diseases .
    PMEG-DP disodium
  • HY-N6834

    Others Others
    Fructo-oligosaccharide DP10/GF9 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=10). Fructo-oligosaccharides (FOS) are composed of 9 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .
    Fructo-​oligosaccharide DP10/GF9
  • HY-N7009

    Others Metabolic Disease
    Fructo-oligosaccharide DP12/GF11 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=12). Fructo-oligosaccharides (FOS) are composed of 11 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end .
    Fructo-oligosaccharide DP12/GF11
  • HY-141481

    PROTACs EGFR PARP Cancer
    DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP .
    DP-C-4
  • HY-N8059

    Others Others
    Fructo-oligosaccharide DP14 is an oligosaccharide that can be isolated from Atractylodes lancea .
    Fructo-oligosaccharide DP14
  • HY-N7938

    Others Others
    Fructo-oligosaccharide DP13 is an Inulin (HY-N7075)-type fructo-oligosaccharide that can be isolated from Morinda Officinalis .
    Fructo-oligosaccharide DP13
  • HY-B2221S2

    Isotope-Labeled Compounds Others
    U-sup>13C Cellulose high DP from wheat is the cellulose (HY-B2221) isolated from wheat, that is consist of abundant glucose and all the carbon atoms are labeled with isotope 13C .
    U-13C Cellulose high DP from wheat
  • HY-P10395

    Opioid Receptor Neuropeptide FF Receptor Neurological Disease
    DP50 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP50 can be used in analgesia-related research .
    DP50
  • HY-P10394

    Opioid Receptor Neuropeptide FF Receptor Neurological Disease
    DP32 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP32 can be used in analgesia-related research .
    DP32

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