168555-66-6
Chemical Structure
Fosbretabulin disodium
Synonym(s): CA 4DP; CA 4P; Combretastatin A4 disodium phosphate
- CAS No.: 168555-66-6
- Formula:C18H19Na2O8P
- Molecular Weight:440.29
IUPAC Name: sodium (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl phosphate
InChIKey: VXNQMUVMEIGUJW-XNOMRPDFSA-L
SMILES: COC1=C(OC)C(OC)=CC(/C=C\C2=CC=C(OC)C(OP(O[Na])(O[Na])=O)=C2)=C1
Biological Activity: Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[1][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fosbretabulin disodium | 99.91% | Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis. | ||||||||||||||||||||
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- [1]. Shen CH, et, al. Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model. Br J Pharmacol. 2010 Aug;160(8):2008-27. [Content Brief]
- [3]. Tozer GM, et, al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res. 1999 Apr 1;59(7):1626-34. [Content Brief]
Keywords
