950688-14-9
Chemical Structure
Timapiprant sodium
Synonym(s): OC000459 sodium
- CAS No.: 950688-14-9
- Formula:C21H16FN2NaO2
- Molecular Weight:370.35
IUPAC Name: sodium 2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetate
InChIKey: XKRNYIKRDAGPQZ-UHFFFAOYSA-M
SMILES: O=C(O[Na])CN1C2=CC=C(F)C=C2C(CC3=NC4=C(C=CC=C4)C=C3)=C1C
Biological Activity: Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Timapiprant sodium | 98.71% | Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils. | ||||||||||||||||||||
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Keywords
