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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
E2F1 protein
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "E2F1 protein" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P79451
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin‑Conjugating Enzyme E2 L3; E2 Ubiquitin‑Conjugating Enzyme L3; Ubiquitin‑Conjugating Enzyme E2‑F1; Ubiquitin Carrier protein L3; Ubiquitin‑protein Ligase L3; L‑UBC; Ubiquitin‑Conjugating Enzyme E
Species:
Human
Source:
E. coli
Cat. No.: HY-175397
Synonyms: DFHBI-thalidomide
Research Areas:
Dth (DFHBI-thalidomide) is an RNA aptamer-based PROTAC degrader. Dth can degrade a variety of endogenous proteins (such as mCherry, p50, p65 and E2F1) by replacing the 3′ module on the RNA scaffold with the RNA aptamer corresponding to the target protein. Dth upregulates IκB-α and Bax, and downregulates Bcl-2 and VEGF. Dth generates green fluorescence upon binding to the Broccoli RNA aptamer, enabling the tracing of RNA scaffolds. Dth can be used in cancer-related research .
Cat. No.: HY-182902
Target:
Research Areas:
IHMT-15137 is a BMX inhibitor with an IC50 of 26.97 nM. IHMT-15137 covalently binds to BMX Cys496 within the ATP-binding pocket, inhibits BMX phosphorylation at Tyr566, and disrupts the BMX-ERK1/2-Cyclin D1/CDK4/6-E2F1 signaling axis. IHMT-15137 reduces E2F1 protein stability via decreased Ser332/337 phosphorylation, increased ubiquitination, and ubiquitin-proteasome pathway degradation. IHMT-15137 induces cell cycle arrest, apoptosis, DNA damage, and suppresses cell migration and invasion. IHMT-15137 can be used for the research of small cell lung cancer .
Cat. No.: HY-123612
Research Areas:
JAS239 is a blood-brain barrier-permeable ChoK inhibitor. JAS239 inhibits phosphocholine synthesis and reduces the expression level of E2F1 protein. JAS239 exhibits near-infrared fluorescence properties. JAS239 exerts anti-tumor activity against glioblastoma. JAS239 can be used in studies related to glioblastoma .
Cat. No.: HY-P85613
Synonyms: Dmel\CG6376; Dmel_CG6376; drosE2F1; E; Sev-CycE; 3A; E; var; 3-93E; E2-promoter binding facto; E2F 1; E2F transcription factor 1; E2F-1; E2f-PA; E2f-PB; E2f-PC; E2F1; E2F1 E2F transcription factor 1; E2F1_HUMAN; Evar; 3; 164; KIAA4009; l; 3; 07172; l; 3; j3B1; l; 3; j3C2; l; 3; rM729; mKIAA4009; OTTHUMP00000030661; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1.
Cat. No.: HY-P85616
Synonyms: Dmel\CG6376; Dmel_CG6376; drosE2F1; E; Sev-CycE; 3A; E; var; 3-93E; E2-promoter binding facto; E2F 1; E2F transcription factor 1; E2F-1; E2f-PA; E2f-PB; E2f-PC; E2F1; E2F1 E2F transcription factor 1; E2F1_HUMAN; Evar; 3; 164; KIAA4009; l; 3; 07172; l; 3; j3B1; l; 3; j3C2; l; 3; rM729; mKIAA4009; OTTHUMP00000030661; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1.
Target:
Research Areas:
VHLL-BCN is a ligand targeting the VHL E3 ligase, which can be used for the synthesis of PROTAC molecules. As a key component of the copper-free SPAAC-based rapid synthesis platform for transcription factor PROTACs, VHLL-BCN is applicable to cancer-related research .
Cat. No.: HY-P703297
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin‑Conjugating Enzyme E2 L3; E2 Ubiquitin‑Conjugating Enzyme L3; Ubiquitin‑Conjugating Enzyme E2‑F1; Ubiquitin Carrier protein L3; Ubiquitin‑protein Ligase L3; L‑UBC; Ubiquitin‑Conjugating Enzyme E
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P703298
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin‑Conjugating Enzyme E2 L3; E2 Ubiquitin‑Conjugating Enzyme L3; Ubiquitin‑Conjugating Enzyme E2‑F1; Ubiquitin Carrier protein L3; Ubiquitin‑protein Ligase L3; L‑UBC; Ubiquitin‑Conjugating Enzyme E
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P701348
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin‑Conjugating Enzyme E2 L3; E2 Ubiquitin‑Conjugating Enzyme L3; Ubiquitin‑Conjugating Enzyme E2‑F1; Ubiquitin Carrier protein L3; Ubiquitin‑protein Ligase L3; L‑UBC; Ubiquitin‑Conjugating Enzyme E
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
