2874203-49-1
Chemical Structure
VHLL-BCN
- CAS No.: 2874203-49-1
- Formula:C35H45N5O6S
- Molecular Weight:663.83
IUPAC Name: ((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethyl)carbamate
InChIKey: BJZGOBPFQRYATQ-AVRGSWKPSA-N
SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CNC(OC[C@@H]4[C@@]5([H])[C@]4([H])CCC#CCC5)=O)=O
Biological Activity: VHLL-BCN is a ligand targeting the VHL E3 ligase, which can be used for the synthesis of PROTAC molecules. As a key component of the copper-free SPAAC-based rapid synthesis platform for transcription factor PROTACs, VHLL-BCN is applicable to cancer-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VHLL-BCN | 95.06% | VHLL-BCN is a ligand targeting the VHL E3 ligase, which can be used for the synthesis of PROTAC molecules. As a key component of the copper-free SPAAC-based rapid synthesis platform for transcription factor PROTACs, VHLL-BCN is applicable to cancer-related research. | ||||||||||||||||||||
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References
- [1]. Pasieka A, et al. Click chemistry and targeted degradation: a winning combination for medicinal chemists?[J]. ChemMedChem, 2023, 18(20): e202300422.
- [2]. Liu J, et al. TF-PROTACs enable targeted degradation of transcription factors[J]. Journal of the American Chemical Society, 2021, 143(23): 8902-8910.
