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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
289 Results for "
EPI
" in MedChemExpress (MCE) Product Catalog:
Products (289)
289 Results for "EPI" in MCE Product Catalog:
15
15 Publications Verification
Synonyms: (-)-EPIcatechol; EPIcatechin; EPI-Catechin
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Anti-aging Plants Camellia sinensis (L.) O. Ktze. Endogenous metabolite Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer Theaceae
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Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
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Natural Products Microorganisms Other Diseases Brassinolide Phytohormone Disease Research Fields Agricultural Research
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1 Cited Publications
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EPI-7170, a ralaniten analogue, is a potent androgen receptor N-terminal structural domain antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 has antitumor effects against enzalutamide resistant castration-resistant prostate cancer (CRPC) .
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EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC50 of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer .
Cat. No.: HY-16772
CAS No.: 1213269-98-7
Synonyms: α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075
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EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione .
Cat. No.: HY-P99049
CAS No.: 2305607-45-6
Synonyms: APX005M; APX005M; EPI-0050
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Synonyms: EPI-002
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Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC) .
Synonyms: EPI-506
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Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7 .
Synonyms: (-)-EPIcatechol(Standard); EPIcatechin(Standard); EPI-Catechin (Standard)
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EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .
Cat. No.: HY-77572
CAS No.: 78454-17-8
Synonyms: 7-EPI-10-deacetyltaxol; 10-Deacetyl-7-EPIpaclitaxel
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Microorganisms Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.
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Cat. No.: HY-N10379
CAS No.: 132923-06-9
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Akt mTOR Apoptosis Reactive Oxygen Species (ROS) CDK Ras HSP VEGFR TNF Receptor Interleukin Related
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19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy .
Synonyms: 27-Deoxyactein
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Synonyms: EPIcholecalciferol
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells .
Cat. No.: HY-N10343
CAS No.: 19237-18-4
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Natural Products other families Other Diseases Glucosinolates Plants Disease Research Fields
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Cat. No.: HY-138149
CAS No.: 106434-14-4
Synonyms: EPI-Avermectin B1a
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2-epi-Abamectin is a degradation product of Abamectin. It is toxic to the two-spotted spider mite in a contact assay with an LC50 value of 4 ppm, which is approximately 100-fold less potent than abamectin.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
