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Results for "

ERK-IN-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (7) Bcl-2 Family (3) c-Fms (1) Caspase (3) COX (2) EGFR (1) Endogenous Metabolite (2) ERK (9) FLT3 (3) Interleukin Related (2) Isotope-Labeled Compounds (1) MEK (1) NF-κB (2) PKC (2) Potassium Channel (2) Reactive Oxygen Species (ROS) (3) Reference Standards (3) STAT (7) VEGFR (1)
By Research Areas:	Cancer (11) Infection (3) Inflammation/Immunology (6) Metabolic Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136579

ASN007 5 Publications Verification ERK-IN-3	ERK	Cancer
ASN007 (ERK-IN-3) is a potent and orally active inhibitor of ERK. ASN007 inhibits ERK1/2 with low single-digit nM IC₅₀ values. ASN007 exhibits significant anti proliferative activity against various tumor cells. ASN007 can be used for the research of cancers driven by RAS mutations .

HY-W013242

Gondoic acid cis-11-Eicosenoic acid	Endogenous Metabolite Reactive Oxygen Species (ROS) PKC ERK STAT	Inflammation/Immunology
Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts. Gondoic acid can exert anti-inflammatory activity by inhibiting the production of ROS and the PKCθ/ERK/STAT3 signaling pathway. Gondoic acid can be used as a raw material for medical supplies and a moisturizing ingredient in cosmetic creams .

HY-B1114

Gliquidone 2 Publications Verification AR-DF 26	Potassium Channel ERK STAT NF-κB COX Interleukin Related Reactive Oxygen Species (ROS)	Metabolic Disease
Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits *ERK/STAT3/NF-κB* phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers .

HY-136579A

ASN007 benzenesulfonate 5 Publications Verification ERK-IN-3 benzenesulfonate	ERK	Cancer
ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of ERK. ASN007 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC₅₀ values. ASN007 benzenesulfonate exhibits significant anti proliferative activity against various tumor cells. ASN007 benzenesulfonate can be used for the research of cancers driven by RAS mutations .

HY-N6801

Nivalenol	Caspase Apoptosis Bcl-2 Family	Infection Inflammation/Immunology Cancer
Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, *ERK, caspase-3*, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia ^[3].

HY-N6801S

Nivalenol-13C15	Isotope-Labeled Compounds Caspase Apoptosis Bcl-2 Family	Infection Inflammation/Immunology Cancer
Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.

HY-E70844

MAP2K2 Recombinant Human Active Protein Kinase	MEK	Cancer
MAP2K2 (MEK2) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. MAP2K2 phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1. MAP2K2 Recombinant Human Active Protein Kinase is a recombinant MAP2K2 protein that can be used to study MAP2K2-related functions .

HY-N6801R

Nivalenol (Standard)	Reference Standards Caspase Apoptosis Bcl-2 Family	Infection Inflammation/Immunology Cancer
Nivalenol (Standard) is the analytical standard of Nivalenol (HY-N6801). This product is intended for research and analytical applications. Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.

HY-168954

CSF1R-IN-26	c-Fms Apoptosis Akt ERK STAT	Inflammation/Immunology Cancer
CSF1R-IN-26 (Compound III-1) is the inhibitor for CSF-1R with an IC₅₀ of 20.07 nM. CSF1R-IN-26 promotes the polarization of M2 macrophages to M1 macrophages, thereby inducing apoptosis in MC-38 cancer cell. CSF1R-IN-26 inhibits the activation of *AKT/ERK/STAT3* signaling pathway. CSF1R-IN-26 reconstructs the tumor immune microenvironment and exhibits antitumor activity in mouse models. CSF1R-IN-26 exhibits pharmacokinetics characteristics in SD rats with a half-life 1.86 hours, and an oral bioavailability of 79.22% .

HY-W013242R

Gondoic acid (Standard) cis-11-Eicosenoic acid (Standard)	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) PKC ERK STAT	Inflammation/Immunology
Gondoic acid (Standard) is an analytical standard for Gondoic acid. This product is used for research and analytical applications. Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts. Gondoic acid can exert anti-inflammatory activity by inhibiting the production of ROS and the PKCθ/ERK/STAT3 signaling pathway. Gondoic acid can be used as a raw material for medical supplies and a moisturizing ingredient in cosmetic creams .

HY-173038

EGFR-IN-151	EGFR ERK STAT Apoptosis	Cancer
EGFR-IN-151 (Compound 10) inhibits EGFR and its downstream signaling pathways *ERK/STAT3. EGFR-IN-151 inhibits the proliferation of a variety lung cancer cells (IC₅₀s for NCI-H1781, HCC827, NCI-H3255 and NCI-H1975 is 11.7, 5.19, 7.32 and 1.53 μM, respectively), inhibits the colony formation and migration of H1975, arrests the cell cycle at G1 phase, and induces apoptosis* in H1975 .

HY-174137

FLT3-IN-31	Apoptosis FLT3	Cancer
FLT3-IN-31 (compound 10q) is a potent *FLT3* inhibitor with IC₅₀ values of 0.16, 2.4 nM for FLT3, FLT3-D835Y, resprctively. FLT3-IN-31 shows antiproliferation activity. FLT3-IN-31 decreases the protein expression of p-FLT3, P-STAT5, P-ERK. FLT3-IN-31 induces apoptosis and cell cycle arrest at G1 phase. FLT3-IN-31 shows antitumor activity .

HY-B1114R

Gliquidone (Standard) AR-DF 26 (Standard)	Potassium Channel Reference Standards ERK STAT NF-κB COX Interleukin Related	Metabolic Disease
Gliquidone (Standard) is the analytical standard of Gliquidone. This product is intended for research and analytical applications. Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits *ERK/STAT3/NF-κB* phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers .

HY-182004

FLT3-IN-40	FLT3	Cancer
FLT3-IN-40 (compound 1) is a type I ATP-competitive *FLT3* inhibitor with an IC₅₀ of 16.26 nM. FLT3-IN-40 reduces the autophosphorylation level of *FLT3* and the phosphorylation level of downstream *ERK*. FLT3-IN-40 exhibits antiproliferative, cell cycle regulatory and apoptosis-inducing activities. FLT3-IN-40 can be used in research related to acute myeloid leukemia .

HY-179497

FLT3-IN-37	FLT3 VEGFR Akt STAT ERK Apoptosis	Cancer
FLT3-IN-37 (Compound 6z) is a potent inhibitor of *FLT3-ITD, with IC₅₀* values of 1.5 and 3.4 nM for *FLT3-ITD* and TEL-VEGFR2, respectively. FLT3-IN-37 exhibits high selectivity for wild-type FLT3 (WT) and c-Kit. FLT3-IN-37 inhibits FLT3 phosphorylation and downregulates the expression of p-Akt, p-STAT5, and *p-ERK*. FLT3-IN-37 exerts anti-leukemia effects by blocking the cell cycle and inducing apoptosis (apoptosis). FLT3-IN-37 can be used for research on acute myeloid leukemia (AML) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013242

Gondoic acid cis-11-Eicosenoic acid	Classification of Application Fields Cardiospermum halicacabum Ketones, Aldehydes, Acids Sapindaceae Other Diseases Plants Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) PKC ERK STAT
Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts. Gondoic acid can exert anti-inflammatory activity by inhibiting the production of ROS and the PKCθ/ERK/STAT3 signaling pathway. Gondoic acid can be used as a raw material for medical supplies and a moisturizing ingredient in cosmetic creams .

HY-N6801

Nivalenol	Infection Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Inflammation/Immunology Disease Research Fields Source Classification	Caspase Apoptosis Bcl-2 Family
Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, *ERK, caspase-3*, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia ^[3].

HY-N6801R

Nivalenol (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source Classification	Reference Standards Caspase Apoptosis Bcl-2 Family
Nivalenol (Standard) is the analytical standard of Nivalenol (HY-N6801). This product is intended for research and analytical applications. Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.

HY-W013242R

Gondoic acid (Standard) cis-11-Eicosenoic acid (Standard)	Structural Classification Cardiospermum halicacabum Ketones, Aldehydes, Acids Sapindaceae Plants Source Classification	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) PKC ERK STAT
Gondoic acid (Standard) is an analytical standard for Gondoic acid. This product is used for research and analytical applications. Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts. Gondoic acid can exert anti-inflammatory activity by inhibiting the production of ROS and the PKCθ/ERK/STAT3 signaling pathway. Gondoic acid can be used as a raw material for medical supplies and a moisturizing ingredient in cosmetic creams .

Cat. No.	Product Name	Chemical Structure

HY-N6801S

Nivalenol-13C15
Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.

Nivalenol-13C15

Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.

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