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Results for "

FXIIa Inhibitor

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Peptides

2

Inhibitory Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175735
    Factor XI-IN-2

    		Factor XI Cardiovascular Disease
    Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus .
    Factor XI-IN-2
  • HY-163348
    FXIIa-IN-4
    1 Publications Verification

    		 Factor Xa Thrombin Cardiovascular Disease
    FXIIa-IN-4 (compound 22) is a potent, selective human FXIIa inhibitor with the IC50 of 0.032 μM, 0.30 μM, ＞50 μM for FXIIa, thrombin and FXIa, respectively. FXIIa-IN-4 can be used for study of anticoagulant .
    FXIIa-IN-4
  • HY-152150
    Thrombin inhibitor 7

    		Ser/Thr Protease Metabolic Disease
    Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity .
    Thrombin inhibitor 7
  • HY-149397
    FXIIa-IN-2

    		Thrombin Cardiovascular Disease
    FXIIa-IN-1-IN-2 (Compound 21) is a Factor XIIa inhibitor (Ki app: 62.2 nM). FXIIa-IN-1-IN-2 can be used for research of thrombosis .
    FXIIa-IN-2
  • HY-149396A
    FXIIa-IN-1 hydrochloride

    		Thrombin Cardiovascular Disease
    FXIIa-IN-1 hydrochloride is the hydrochloride of FXIIa-IN-1 (HY-149396). FXIIa-IN-1 (Compound 22) is a Factor XIIa inhibitor (Ki app: 97.8 nM). FXIIa-IN-1 can be used for research of thrombosis .
    FXIIa-IN-1 hydrochloride
  • HY-163347
    FXIIa-IN-3

    		Factor Xa Cardiovascular Disease
    FXIIa-IN-3 (Compound 8) is a potent and selective Factor XIIa (FXIIa) inhibitor, with an IC50 of 0.045 μM. FXIIa-IN-3 also exhibits a substantial margin of selectivity against related serine proteases, including FXIa, FXa, and FIXa. FXIIa-IN-3 can be used for the research of thromboembolic diseases .
    FXIIa-IN-3
  • HY-162646
    FXIIa-IN-5

    		Thrombin Cardiovascular Disease
    FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474)-induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg) .
    FXIIa-IN-5
  • HY-P10860
    cMCoFx1

    		Factor Xa Cardiovascular Disease
    cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (KD: 900 pM) and inhibitory activity (Ki: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic .
    cMCoFx1
  • HY-184008
    FXIIa-IN-6

    		Ser/Thr Protease Inflammation/Immunology
    FXIIa-IN-6 is a potent, selective, and irreversible covalent inhibitor of Factor XIIa (FXIIa) with an IC50 of 2 nM. FXIIa-IN-6 exhibits ≥2,500-fold selectivity over related serine proteases. FXIIa-IN-6 exhibits favorable anticoagulant and anti-inflammatory activities and can be used in sepsis research .
    FXIIa-IN-6
  • HY-P991994
    REGN9533

    		Factor Xa Cardiovascular Disease
    REGN9533 is a human-derived monoclonal antibody against FXII/FXIIa with high affinity for FXII, FXIIa and β-FXIIa. REGN9533 selectively inhibits the intrinsic coagulation pathway and FXIIa-driven plasma kallikrein activity. REGN9533 is applicable to FXIIa-related diseases such as thrombosis and hereditary angioedema .
    REGN9533
  • HY-P991993
    AB054

    		Factor Xa Cardiovascular Disease
    AB054 is a humanized monoclonal antibody targeting factor XII (FXII). AB054 inhibits FXII activation and FXIIa activity through specific binding to the catalytic domain of FXII, and exerts antithrombotic effects in a concentration-dependent manner. AB054 can be used in studies related to thrombosis .
    AB054

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