2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. AB054

AB054 is a humanized monoclonal antibody targeting factor XII (FXII). AB054 inhibits FXII activation and FXIIa activity through specific binding to the catalytic domain of FXII, and exerts antithrombotic effects in a concentration-dependent manner. AB054 can be used in studies related to thrombosis.

For research use only. We do not sell to patients.

AB054

AB054 Chemical Structure

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Description

AB054 is a humanized monoclonal antibody targeting factor XII (FXII). AB054 inhibits FXII activation and FXIIa activity through specific binding to the catalytic domain of FXII, and exerts antithrombotic effects in a concentration-dependent manner. AB054 can be used in studies related to thrombosis[1].

Species Reactivity

Human
In Vitro

AB054 (0-100 μg/mL; 5 min) significantly prolongs the aPTT of human plasma and baboon plasma in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AB054 Related Antibodies
In Vivo

AB054 (2-5 mg/kg; i.v. bolus; 30 min before experiment) significantly inhibits platelet-dependent thrombosis in baboon membrane oxygenators, and its antithrombotic effect becomes more pronounced when used in combination with Heparin (HY-17567)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Baboons (juvenile male, 9~15kg, with healed surgically implanted chronic arteriovenous shunt device)[1]
Dosage: 5 mg/kg (single agent); 2 mg/kg (plus 5 mg/kg 24h prior, in combination with 20 U/kg heparin)
Administration: i.v. bolus; 30 min before experiment (AB054); 15 min before experiment (heparin)
Result: Reduced platelet deposition rate, terminal platelet deposition, and terminal fibrin content in.
Maintained hemostatic parameters (bleeding time, blood loss, bleeding rate) within normal baboon ranges across all treatment groups.
Gene ID

2161  [NCBI]

Accession
Target

F12/Factor XII
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[AB054]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AB054 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB054AB 054AB-054Factor XaFxaFXIIanti-thrombotic agentthrombosisactivated FXIIFXIIaFactor XIIInhibitorinhibitorinhibit

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