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Isoforms Recommended:	FFAR4

Results for "

GPR120

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GPR119 (1) GPR84 (1) Apoptosis (3) Bacterial (2) CGRP Receptor (6) Endogenous Metabolite (6) Free Fatty Acid Receptor (28) Fungal (3) GLP Receptor (1) Influenza Virus (2) Isotope-Labeled Compounds (4) NF-κB (6) Potassium Channel (2) PPAR (1) Reference Standards (7) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Infection (7) Inflammation/Immunology (15) Metabolic Disease (23) Neurological Disease (1)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: GPR39 G2A (GPR132) EBI2/GPR183 GPR84 Kisspeptin Receptor Succinate Receptor 1 GPR55 GPR88 GPR171 GPR35 GPR119 GPR4 GPR139 GPR6 GPR65 GPR52 GPR68 GPR109A MCHR1 (GPR24) CX3CR1 Neuropeptide S Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011303

Phytosphingosine 4 Publications Verification 4-Hydroxysphinganine	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology Cancer
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of *GPR120* with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-N0040

Ginsenoside Rb2 3 Publications Verification Ginsenoside C	Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate *GPR120* gene expression. Ginsenoside Rb2 has antiviral effects.

HY-100881

TUG-891 Maximum Cited Publications 13 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120) .

HY-15589

GW9508 5+ Cited Publications	Free Fatty Acid Receptor Potassium Channel	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and *GPR120* agonist with pEC₅₀s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over *GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (K_ATP) channels* opener. Anti-inflammatory and anti-atherosclerotic activities .

HY-19996

AH-7614 5+ Cited Publications	Free Fatty Acid Receptor	Metabolic Disease
AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC₅₀s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC₅₀<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist .

HY-101492

GPR120 Agonist 3 2 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
GPR120 Agonist 3 is a selective *Gpr120* agonist with a logEC₅₀ of 7.62.

HY-124571

ZQ-16	GPR84	Inflammation/Immunology
ZQ-16 is a potent and selective GPR84 agonist with an EC₅₀ value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120 .

HY-114610

13Z,16Z-Docosadienoic acid	Endogenous Metabolite Free Fatty Acid Receptor Bacterial	Infection Cancer
13Z,16Z-Docosadienoic acid is a *GPR120* agonist with bactericidal activity. 13Z,16Z-Docosadienoic acid serves as a potential biomarker for canine mammary tumors. 13Z,16Z-Docosadienoic acid is used in the research of bacterial infections, Lyme disease, Graves' disease and mammary tumors .

HY-N2540

(±)-Pinocembrin (±)-5,7-Dihydroxyflavanone; NSC 43318	Free Fatty Acid Receptor	Others
(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line .

HY-120657

9-PAHSA	CGRP Receptor NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology
9-PAHSA is an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-50162

GPR120 modulator 1	Free Fatty Acid Receptor	Metabolic Disease
GPR120 modulator 1 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F1. GPR120 modulator 1 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes .

HY-50172

GPR120 modulator 2	Free Fatty Acid Receptor	Metabolic Disease
GPR120 modulator 2 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F13. GPR120 modulator 2 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes .

HY-162689

GprA	Free Fatty Acid Receptor	Inflammation/Immunology
GprA is a new synthetic agonist of G-protein-coupled receptor 120/free fatty acid receptor 4 (GPR120/FFAR4), with an AC₅₀ of 203 nM on human GPR120 full isoform. GprA can be used in the research for NAFLD .

HY-109692

GPR120 Agonist 5	Free Fatty Acid Receptor	Metabolic Disease Inflammation/Immunology
GPR120 Agonist 5 (compound 12) is an agonist targeting *GPR120* (EC₅₀=1.2 μM). GPR120 Agonist 5 promotes the release of glucagon-like 1 (GLP-1) by binding to the *GPR120* receptor, which in turn binds to its receptors on pancreatic beta cells, increasing insulin secretion and thereby lowering blood sugar levels. GPR120 Agonist 5 also helps reduce chronic low-grade inflammation, which plays an important role in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. GPR120 Agonist 5 can be used to investigate the mechanism of action of *GPR120* in metabolic and inflammatory diseases .

HY-N3977

Grifolic acid	Free Fatty Acid Receptor	Inflammation/Immunology
Grifolic acid is a phenolic compound that is first extracted from the mushroom Albatrellus confluens. Grifolic acid acts as an agonist of the free fatty acid receptor *(FFAR4/GPR120)* .

HY-160628

GPR120 Agonist 4	Free Fatty Acid Receptor	Metabolic Disease
GPR120 Agonist 4 (example 1) is a *GPR120* agonist，with the EC₅₀ values of 1 μM and 0.35 μM for β-arrestin A and Calcium A. GPR120 Agonist 4 can be used for the research of type II diabetes mellitus .

HY-108711

GPR120 Agonist 1	Free Fatty Acid Receptor	Metabolic Disease
GPR120 Agonist 1 is a potent and selective *GPR120* agonist, and possesses promising antidiabetic effect and good safety profile to be a development candidate .

HY-111353

GPR120 Agonist 2	Free Fatty Acid Receptor	Metabolic Disease
GPR120 Agonist 2 (example 206) is a *GPR120* agonist that can be uesd for the study of type II diabetes and diseases associated with poor glycemic control .

HY-15589R

GW9508 (Standard)	Free Fatty Acid Receptor Potassium Channel Reference Standards	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GW9508 (Standard) is the analytical standard of GW9508. This product is intended for research and analytical applications. GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities .

HY-176838

LXT34	Free Fatty Acid Receptor GLP Receptor	Inflammation/Immunology
LXT34 (Example 2) is a *GPR120* agonist. LXT34 has an anti-inflammatory activity. LXT34 promotes GLP-1 formation in the gastrointestinal tract and improves insulin resistance in macrophages and pancreas cells. LXT34 can be used for inflammatory diseases, such as type 2 diabetes, obesity and non-alcoholic fatty liver research .

HY-101492R

GPR120 Agonist 3 (Standard)	Reference Standards Free Fatty Acid Receptor	Metabolic Disease
GPR120 Agonist 3 (Standard) is the analytical standard of GPR120 Agonist 3 (HY-101492). This product is intended for research and analytical applications. GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of 7.62.

HY-Y1624

1,1'-(Azodicarbonyl)-dipiperidine ADDP; SR 4077	Free Fatty Acid Receptor PPAR	Metabolic Disease
1,1'-(Azodicarbonyl)-dipiperidine (ADDP) can be used in the condensation reaction of alcohols with acidic compounds. 1,1'-(Azodicarbonyl)-dipiperidine can also be used in the synthesis of *GPR120* agonists with antidiabetic activity, as well as the synthesis of triple agonists for PPARα, PPARγ, and PPARδ. 1,1'-(Azodicarbonyl)-dipiperidine can be used in metabolic disease research .

HY-W770410

9-PAHSA-13C4	Isotope-Labeled Compounds CGRP Receptor NF-κB	Others
9-PAHSA- ¹³C₄ is ¹³C-labeled 9-PAHSA. 9-PAHSAis an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSAsignificantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSAinduces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSAregulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSAdoes not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSAcan be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-N0040R

Ginsenoside Rb2 (Standard) Ginsenoside C (Standard)	Reference Standards Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rb2 (Standard) is the analytical standard of Ginsenoside Rb2. This product is intended for research and analytical applications. Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.

HY-W727728

MK-8666	Free Fatty Acid Receptor	Metabolic Disease
MK-8666 is a potent and selective partial GPR40 agonist (EC₅₀ = 0.54 nM for human GPR40). MK-8666 shows selectivity over GPR119, GPR43, GPR41, GPR120, and other G-protein-coupled receptors (GPCRs). MK-8666 reduces glucose in the rodent. MK-8666 can be used for type 2 diabetes research ^[1][2].

HY-W011303R

Phytosphingosine (Standard) 4-Hydroxysphinganine (Standard)	Reference Standards Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology Cancer
Phytosphingosine (Standard) is the analytical standard of Phytosphingosine. This product is intended for research and analytical applications. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].

HY-13967

AMG 837 3 Publications Verification	Free Fatty Acid Receptor Bacterial	Infection Metabolic Disease
AMG 837 is an orally active, selective GPR40/FFA1 agonist with an EC₅₀ of 1.5 nM against human GPR40. AMG 837 stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models . AMG 837 binds to the BacA protein and impairs the survival and replication of Brucella. AMG 837 can be used in research related to type 2 diabetes and brucellosis .

HY-120657S

9-PAHSA-d4	Isotope-Labeled Compounds CGRP Receptor NF-κB	Others
9-PAHSA-d₄ is the deuterium labeled 9-PAHSA. 9-PAHSA is an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-100881R

TUG-891 (Standard)	Reference Standards Free Fatty Acid Receptor	Metabolic Disease
TUG-891 (Standard) is the analytical standard of TUG-891. This product is intended for research and analytical applications. TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120) .

HY-N2540R

(±)-Pinocembrin (Standard) (±)-5,7-Dihydroxyflavanone (Standard); NSC 43318 (Standard)	Reference Standards Free Fatty Acid Receptor	Others
(±)-Pinocembrin (Standard) is the analytical standard of (±)-Pinocembrin. This product is intended for research and analytical applications. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line .

HY-RS04877

FFAR4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FFAR4 Human Pre-designed siRNA Set A contains three designed siRNAs for FFAR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FFAR4 Human Pre-designed siRNA Set A FFAR4 Human Pre-designed siRNA Set A

HY-W011303S

Phytosphingosine-d7 4-Hydroxysphinganine-d₇	Isotope-Labeled Compounds Fungal Free Fatty Acid Receptor Apoptosis Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology Cancer
Phytosphingosine-d₇ (4-Hydroxysphinganine-d₇) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of *GPR120* with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-182404

Anticancer agent 316	Free Fatty Acid Receptor	Cancer
Anticancer agent 316 (Compound 1) is an anticancer agent. Anticancer agent 316 exerts anticancer activity against colorectal cancers expressing *GPR120*. Anticancer agent 316 can be used in the research of colorectal cancer .

HY-120657R

9-PAHSA (Standard)	Reference Standards CGRP Receptor NF-κB	Cardiovascular Disease Inflammation/Immunology
Flumethrin (Standard) is the analytical standard of Flumethrin. This product is intended for research and analytical applications. 9-PAHSA is an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-144026S

9-PAHSA-d9	CGRP Receptor NF-κB	Inflammation/Immunology
9-PAHSA-d9 is the deuterium labeled 9-PAHSA (HY-120657). 9-PAHSA is an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-120657S1

9-PAHSA-d31	Isotope-Labeled Compounds CGRP Receptor NF-κB	Others
9-PAHSA-d₃₁ is the deuterium labeled 9-PAHSA. 9-PAHSA is an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-115643

AZ13581837	GPR119	Metabolic Disease
AZ13581837 is a *GPR120* agonist with oral effectiveness, human EC₅₀ values of 5.2 nM, and mouse EC₅₀ of 4.3 nM. AZ13581837 signals through Gαq, Gαs, and β-arrestin pathways, reduces cAMP production, stimulates GLP-1 secretion, induces glucose lowering, and increases insulin secretion. AZ13581837 can be used for the research of type 2 diabetes .

HY-RS18817

Ffar4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ffar4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ffar4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar4 Mouse Pre-designed siRNA Set A Ffar4 Mouse Pre-designed siRNA Set A

HY-RS25307

Ffar4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ffar4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ffar4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar4 Rat Pre-designed siRNA Set A Ffar4 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W011303

Phytosphingosine 4 Publications Verification 4-Hydroxysphinganine	Infection Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of *GPR120* with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-N0040

Ginsenoside Rb2 3 Publications Verification Ginsenoside C	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Metabolic Disease Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor
Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate *GPR120* gene expression. Ginsenoside Rb2 has antiviral effects.

HY-114610

13Z,16Z-Docosadienoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Free Fatty Acid Receptor Bacterial
13Z,16Z-Docosadienoic acid is a *GPR120* agonist with bactericidal activity. 13Z,16Z-Docosadienoic acid serves as a potential biomarker for canine mammary tumors. 13Z,16Z-Docosadienoic acid is used in the research of bacterial infections, Lyme disease, Graves' disease and mammary tumors .

HY-N2540

(±)-Pinocembrin (±)-5,7-Dihydroxyflavanone; NSC 43318	Pinus strobusLinn. Flavonoids Classification of Application Fields Pinaceae Flavonones Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Free Fatty Acid Receptor
(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line .

HY-120657

9-PAHSA	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	CGRP Receptor NF-κB
9-PAHSA is an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-N3977

Grifolic acid	Microorganisms Classification of Application Fields Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Free Fatty Acid Receptor
Grifolic acid is a phenolic compound that is first extracted from the mushroom Albatrellus confluens. Grifolic acid acts as an agonist of the free fatty acid receptor *(FFAR4/GPR120)* .

HY-N0040R

Ginsenoside Rb2 (Standard) Ginsenoside C (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Endogenous metabolite Araliaceae Source Classification	Reference Standards Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor
Ginsenoside Rb2 (Standard) is the analytical standard of Ginsenoside Rb2. This product is intended for research and analytical applications. Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.

HY-W011303R

Phytosphingosine (Standard) 4-Hydroxysphinganine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Reference Standards Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine (Standard) is the analytical standard of Phytosphingosine. This product is intended for research and analytical applications. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].

HY-N2540R

(±)-Pinocembrin (Standard) (±)-5,7-Dihydroxyflavanone (Standard); NSC 43318 (Standard)	Pinus strobusLinn. Flavonoids Pinaceae Flavonones Phenols Polyphenols Plants Source Classification	Reference Standards Free Fatty Acid Receptor
(±)-Pinocembrin (Standard) is the analytical standard of (±)-Pinocembrin. This product is intended for research and analytical applications. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line .

HY-120657R

9-PAHSA (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards CGRP Receptor NF-κB
Flumethrin (Standard) is the analytical standard of Flumethrin. This product is intended for research and analytical applications. 9-PAHSA is an orally active endogenous *GPR120* agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

Cat. No.	Product Name	Chemical Structure

HY-W770410

9-PAHSA-13C4

9-PAHSA- ¹³C₄ is ¹³C-labeled 9-PAHSA. 9-PAHSAis an orally active endogenous GPR120 agonist (EC₅₀=18 μM). 9-PAHSAsignificantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSAinduces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSAregulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSAdoes not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSAcan be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-120657S

9-PAHSA-d4

9-PAHSA-d₄ is the deuterium labeled 9-PAHSA. 9-PAHSA is an orally active endogenous GPR120 agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-W011303S

Phytosphingosine-d7

Phytosphingosine-d₇ (4-Hydroxysphinganine-d₇) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-144026S

9-PAHSA-d9

9-PAHSA-d9 is the deuterium labeled 9-PAHSA (HY-120657). 9-PAHSA is an orally active endogenous GPR120 agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

HY-120657S1

9-PAHSA-d31

9-PAHSA-d₃₁ is the deuterium labeled 9-PAHSA. 9-PAHSA is an orally active endogenous GPR120 agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease .

Cat. No.	Product Name		Classification

HY-115643

AZ13581837		Alkynes
AZ13581837 is a *GPR120* agonist with oral effectiveness, human EC₅₀ values of 5.2 nM, and mouse EC₅₀ of 4.3 nM. AZ13581837 signals through Gαq, Gαs, and β-arrestin pathways, reduces cAMP production, stimulates GLP-1 secretion, induces glucose lowering, and increases insulin secretion. AZ13581837 can be used for the research of type 2 diabetes .

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GPR120

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Isotope-Labeled Compounds

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Oligonucleotides

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