2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. TUG-891

TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).

For research use only. We do not sell to patients.

CAS No. : 1374516-07-0

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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of TUG-891:

TUG-891 Related Antibodies

Top Publications Citing Use of Products

    TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345.  [Abstract]

    H&E staining indicated the alleviating effect of Ffar4 on CS‐induced emphysema, with reduced lung destruction and lower MLI in Ffar4‐overexpressing mice and TUG891 (35 mg/kg, p.o.)‐treated mice compared to the CS group.

    TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345.  [Abstract]

    ELISA analysis of BALF supernatant demonstrated markedly reduced levels of proinflammatory factors IL‐6, KC, and IL‐1β in the AAV‐Ffar4+CS group and AAV‐NC+CS+TUG891 (35 mg/kg, p.o.) group.

    TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345.  [Abstract]

    Senescent markers including p53, p21, and p‐Rb were notably downregulated in the AAV‐Ffar4+CS and AAV‐NC+CS+TUG891 (35 mg/kg, p.o.) groups compared to the AAV‐NC+CS group.

    TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345.  [Abstract]

    Immunofluorescence results also indicated a significant decrease in P53 and P21 levels in the airway epithelium of the AAV‐Ffar4+CS and AAV‐NC+CS+TUG891 (35 mg/kg, p.o.) groups compared to the AAV‐NC+CS group.

    TUG-891 purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Aug 29;6(9):e70345.  [Abstract]

    CCK8 results of TUG891 (0., 2.5, 5, 10, 20 μM) with different concentrations in HBE cells for 1 or 24 h.

    View All Free Fatty Acid Receptor Isoform Specific Products:

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    FFAR1 FFAR2 FFAR3 FFAR4

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120)[1].

    In Vitro

    TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    TUG-891 Related Antibodies
    Molecular Weight

    364.41

    Formula

    C23H21FO3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)CCC1=CC=C(OCC2=CC(F)=CC=C2C3=CC=C(C)C=C3)C=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 180 mg/mL (493.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7442 mL 13.7208 mL 27.4416 mL
    5 mM 0.5488 mL 2.7442 mL 5.4883 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Saline

      Solubility: 5.26 mg/mL (14.43 mM); Suspended solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.47%

    SDS (396 KB)

    COA (246 KB) LCMS (98 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7442 mL 13.7208 mL 27.4416 mL 68.6040 mL
    5 mM 0.5488 mL 2.7442 mL 5.4883 mL 13.7208 mL
    10 mM 0.2744 mL 1.3721 mL 2.7442 mL 6.8604 mL
    15 mM 0.1829 mL 0.9147 mL 1.8294 mL 4.5736 mL
    20 mM 0.1372 mL 0.6860 mL 1.3721 mL 3.4302 mL
    25 mM 0.1098 mL 0.5488 mL 1.0977 mL 2.7442 mL
    30 mM 0.0915 mL 0.4574 mL 0.9147 mL 2.2868 mL
    40 mM 0.0686 mL 0.3430 mL 0.6860 mL 1.7151 mL
    50 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.3721 mL
    60 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1434 mL
    80 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8576 mL
    100 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6860 mL
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    TUG-891 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    TUG-8911374516-07-0TUG891TUG 891Free Fatty Acid ReceptorFFARInhibitorinhibitorinhibit

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