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Results for "

GSPT1 degrader-9

" in MedChemExpress (MCE) Product Catalog:
Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-159609
    GSPT1 degrader-9

    		Molecular Glues Cancer
    GSPT1 degrader-9 (Compound F) is a cereblon-based molecular glue degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). GSPT1 degrader-9 inhibits the cell viability of HL-60 with an IC50 of 9.2 nM [1].
    GSPT1 degrader-9
  • HY-159622
    Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl

    		Drug Intermediate Cancer
    Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl is a synthetic intermediate for molecular glue. Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used in synthesis GSPT1 degrader-9 (HY-159610) [1].
    Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl
  • HY-159623
    Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl

    		Drug Intermediate Cancer
    Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl is a synthetic intermediate for molecular glues. Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used to synthesize GSPT1 degrader-9 (HY-159610) [1].
    Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl
  • HY-W599025
    5-Br-4-Cl-Pyrrolo-pyroxypyridine

    		Drug Intermediate Cancer
    5-Br-4-Cl-Pyrrolo-pyroxypyridine is a synthetic intermediate for molecular glues. 5-Br-4-Cl-Pyrrolo-pyroxypyridine can be used for synthesis GSPT1 degrader-9 (HY-159609) [1].
    5-Br-4-Cl-Pyrrolo-pyroxypyridine
  • HY-179499
    PROTAC EZH2 Degrader-9

    		PROTACs Histone Methyltransferase Apoptosis Cancer
    PROTAC EZH2 Degrader-9 is orally active EZH2 PROTAC degrader degrading EZH2 via the ubiquitin-proteasome pathway. PROTAC EZH2 Degrader-9 downregulates PRC2 core subunits and potent inhibition of H3K27me3 without affecting common CRBN neosubstrates while it was selective over GSp'T1 and ikZF1/3. PROTAC EZH2 Degrader-9 exhibits potent antiproliferative activity against multiple cancer cell lines by inducing cell cycle and apoptosis. PROTAC EZH2 Degrader-9 reverses PRC2-mediated gene silencing and inhibiting EZH2 non-catalytic target gene activation. PROTAC EZH2 Degrader-9 can be used for leukemia, lymphoma, and non-small cell lung cancer research [1].
    PROTAC EZH2 Degrader-9
  • HY-181620
    CDK2 degrader 9

    		Molecular Glues CDK Cancer
    CDK2 degrader 9 (compound 1) is a CDK2-targeting Molecular Glue with selectivity for GSPT1 and CDK1. CDK2 degrader 9 promotes the ubiquitination and degradation of CDK2 via the ubiquitin ligase pathway. CDK2 degrader 9 is applicable to research related to cancer, solid tumors and hematologic malignancies [1].
    CDK2 degrader 9

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