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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
GSPT1 degrader-9
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "GSPT1 degrader-9" in MCE Product Catalog:
Cat. No.: HY-159609
CAS No.: 3034310-17-0
Research Areas:
GSPT1 degrader-9 (Compound F) is a cereblon-based molecular glue degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). GSPT1 degrader-9 inhibits the cell viability of HL-60 with an IC50 of 9.2 nM [1].
Cat. No.: HY-159622
CAS No.: 3024909-51-8
Target:
Research Areas:
Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl is a synthetic intermediate for molecular glue. Boc-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used in synthesis GSPT1 degrader-9 (HY-159610) [1].
Cat. No.: HY-159623
CAS No.: 3024909-50-7
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Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl is a synthetic intermediate for molecular glues. Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl can be used to synthesize GSPT1 degrader-9 (HY-159610) [1].
Cat. No.: HY-W599025
CAS No.: 2914920-46-8
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Research Areas:
5-Br-4-Cl-Pyrrolo-pyroxypyridine is a synthetic intermediate for molecular glues. 5-Br-4-Cl-Pyrrolo-pyroxypyridine can be used for synthesis GSPT1 degrader-9 (HY-159609) [1].
Cat. No.: HY-179499
CAS No.: 2978620-84-5
Research Areas:
PROTAC EZH2 Degrader-9 is orally active EZH2 PROTAC degrader degrading EZH2 via the ubiquitin-proteasome pathway. PROTAC EZH2 Degrader-9 downregulates PRC2 core subunits and potent inhibition of H3K27me3 without affecting common CRBN neosubstrates while it was selective over GSp'T1 and ikZF1/3. PROTAC EZH2 Degrader-9 exhibits potent antiproliferative activity against multiple cancer cell lines by inducing cell cycle and apoptosis. PROTAC EZH2 Degrader-9 reverses PRC2-mediated gene silencing and inhibiting EZH2 non-catalytic target gene activation. PROTAC EZH2 Degrader-9 can be used for leukemia, lymphoma, and non-small cell lung cancer research [1].
Cat. No.: HY-181620
Target:
Research Areas:
CDK2 degrader 9 (compound 1) is a CDK2-targeting Molecular Glue with selectivity for GSPT1 and CDK1. CDK2 degrader 9 promotes the ubiquitination and degradation of CDK2 via the ubiquitin ligase pathway. CDK2 degrader 9 is applicable to research related to cancer, solid tumors and hematologic malignancies [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
