CDK2 degrader 9
CDK2 degrader 9 (compound 1) is a CDK2-targeting Molecular Glue with selectivity for GSPT1 and CDK1. CDK2 degrader 9 promotes the ubiquitination and degradation of CDK2 via the ubiquitin ligase pathway. CDK2 degrader 9 is applicable to research related to cancer, solid tumors and hematologic malignancies.
For research use only. We do not sell to patients.
- Formula: C24H17ClF4N6O3
- Molecular Weight:548.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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CDK2 |
In Vitro
CDK2 (cyclin-dependent kinase 2) is a key kinase regulating the G1/S phase transition of the cell cycle. It drives DNA replication by binding to Cyclin E/A, and its overactivation is closely related to the development and progression of various cancers and drug resistance.
Molecular gluten degraders are small molecules that induce novel protein-protein interactions between target proteins and E3 ubiquitin ligases. They trigger ubiquitination and proteasome degradation of target proteins by forming ternary complexes.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 548.88
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Formula C24H17ClF4N6O3
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SMILES
FC(F)(F)C1=CC=C(C2=NC(NCC3=CC(Cl)=C(CN(C4CCC(NC4=O)=O)C5=O)C5=C3F)=NC=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK2 degrader 9 Related Classifications
HY-181620 Related Classifications
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