Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
HCoV-OC43-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "HCoV-OC43-IN-1" in MCE Product Catalog:
HCoV-OC43-IN-1 (Compound IV-16) is a coronavirus HCoV-OC43 inhibitor. HCoV-OC43-IN-1 has antiviral efficacy (EC50: 90 nM). HCoV-OC43-IN-1 inhibits the mRNA level and expression of viral nucleocapsid protein (NP) .
Cat. No.: HY-180673
Target:
Research Areas:
Mpro/RdRp-IN-1 (Compound 1) is a dual-target inhibitor against SARS-CoV-2, targeting RdRp (EC50 = 25.45) and Mpro (IC50 = 125.4 μM). Mpro/RdRp-IN-1 exhibits EC₅₀ for HCoV-OC43 of 4.79 μM, and the selectivity index (SI) is 10.89. Mpro/RdRp-IN-1 can be used for studying SARS-CoV-2 and HCoV-OC43 infections .
Cat. No.: HY-182704
CAS No.: 832680-32-7
Synonyms: SBI-1275844
Research Areas:
SBI-5844 (SBI-1275844) is a eIF4F complex inhibitor and antiviral agent. SBI-5844 disrupts the assembly of the eIF4F complex and blocks the interaction between eIF4E and eIF4G. SBI-5844 inhibits the synthesis of HCoV-OC43 nucleocapsid protein and reduces the levels of HCoV-OC43 RNA and total protein. SBI-5844 can be used in studies related to human coronavirus OC43 (HCoV-OC43) infection .
Cat. No.: HY-184687
Target:
Research Areas:
SARS-CoV-2 3CLpro-IN-39 (compound 7c) is a broad-spectrum antiviral agent and 3CLpro inhibitor that inhibits SARS-CoV-2, HCoV-OC43, HCoV-HKU1 and HCoV-NL63 3CL pro with IC50 values of 20, 710, 22 and 470 nM, respectively. SARS-CoV-2 3CLpro-IN-39 functionally inhibits the 3CLpro enzymatic activity of different coronaviruses. SARS-CoV-2 3CLpro-IN-39 exhibits anti-SARS-CoV-2 and anti-HCoV-NL63 activities. SARS-CoV-2 3CLpro-IN-39 can be used in the research of coronavirus infections .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
