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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
HEK-293A
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "HEK-293A" in MCE Product Catalog:
11
Target:
Research Areas:
Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .
1
1 Cited Publications
Synonyms: NNC0076-0079; 76-0079
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Research Areas:
Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL). Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cells
overexpressing Lipe with an IC50 value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism .
Cat. No.: HY-13285R
CAS No.: 355025-24-0
Synonyms: Debio 0719 (Standard)
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Research Areas:
Ki16425 (Standard) is the analytical standard of Ki16425. This product is intended for research and analytical applications. Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .
Cat. No.: HY-183657
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Research Areas:
GPR3 inverse agonist-1 is a GPR3 inverse agonist with low micromolar potency in conformational analysis. GPR3 inverse agonist-1 inhibits GPR3-dependent Gs activity in HEK293A cells with an EC50 of 250 nM, and exhibits an EC50 of 2 μM in cAMP assays. GPR3 inverse agonist-1 induces concentration-dependent changes in BRET signals in GPR3 conformational biosensors (EC50 = 5 μM), reduces basal Gs activity downstream of GPR3, and competes for binding sites with the GPR3 agonist DPI (HY-100965). GPR3 inverse agonist-1 can be used in research related to Alzheimer's disease .
Cat. No.: HY-183657A
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Research Areas:
GPR3 inverse agonist-1 TFA is a GPR3 inverse agonist with low micromolar potency in conformational analysis. GPR3 inverse agonist-1 TFA inhibits GPR3-dependent Gs activity in HEK293A cells with an EC50 of 250 nM, and exhibits an EC50 of 2 μM in cAMP assays. GPR3 inverse agonist-1 TFA induces concentration-dependent BRET signal changes in GPR3 conformational biosensors (EC50 = 5 μM), reduces basal Gs activity downstream of GPR3, competes for binding sites with the GPR3 agonist DPI (HY-100965). GPR3 inverse agonist-1 TFA can be used in research related to Alzheimer's disease .
Cat. No.: HY-N21988
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
