2 Results for "

HY-P4882A

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "HY-P4882A" in MCE Product Catalog:

(Pyr3)-Amyloid β-Protein (3-42) TFA
(Pyr3)-Amyloid β-Protein (3-42) TFA
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Cat. No.: HY-P4882A
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

(Pyr3)-Amyloid β-Protein (3-42) TFA is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) TFA is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits .
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(Pyr3)-Amyloid β-Protein (3-42)
(Pyr3)-Amyloid β-Protein (3-42)
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Cat. No.: HY-P4882
CAS No.: 183449-57-2
Target:  

Amyloid-β Tau Protein

Research Areas:  

Neurological Disease

(Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated pyroglutamylated β-amyloid peptide. (Pyr3)-Amyloid β-Protein (3-42) forms stable β-sheet structures across different pH values, co-oligomerizes with Aβ1-42 to form cytotoxic oligomers, induces tau-dependent cytotoxicity and neuronal loss, inhibits hippocampal LTP, and exhibits stronger protease resistance. (Pyr3)-Amyloid β-Protein (3-42) exists in the brain tissues of human Alzheimer's disease patients, correlates with the pathogenesis of Alzheimer's disease, and follows a unique, faster oligomerization pathway. (Pyr3)-Amyloid β-Protein (3-42) can be used in Alzheimer's disease-related research .
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