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Hydrochloride

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By Targets:	5-HT Receptor (4) Adrenergic Receptor (1) Akt (1) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (2) Calcium Channel (1) Calmodulin (1) Caspase (1) CDK (1) Cholinesterase (ChE) (2) CRFR (1) Dopamine Receptor (2) Drug Derivative (1) Drug Intermediate (6) Drug Metabolite (2) EGFR (1) Endogenous Metabolite (2) Environmental Pollutants (1) FKBP (1) Fluorescent Dye (1) iGluR (2) Imidazoline Receptor (1) Lactate Dehydrogenase (1) Ligands for Target Protein for PROTAC (1) mAChR (3) MAP4K (1) Mitochondrial Metabolism (1) Potassium Channel (1) PROTACs (1) Reference Standards (3) Serotonin Transporter (1) Sodium Channel (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (1) Neurological Disease (14)

By Targets:

5-HT Receptor (4)

Adrenergic Receptor (1)

Akt (1)

Apoptosis (1)

Autophagy (1)

Biochemical Assay Reagents (2)

Calcium Channel (1)

Calmodulin (1)

Caspase (1)

CDK (1)

Cholinesterase (ChE) (2)

CRFR (1)

Dopamine Receptor (2)

Drug Derivative (1)

Drug Intermediate (6)

Drug Metabolite (2)

EGFR (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

FKBP (1)

Fluorescent Dye (1)

iGluR (2)

Imidazoline Receptor (1)

Lactate Dehydrogenase (1)

Ligands for Target Protein for PROTAC (1)

mAChR (3)

MAP4K (1)

Mitochondrial Metabolism (1)

Potassium Channel (1)

PROTACs (1)

Reference Standards (3)

Serotonin Transporter (1)

Sodium Channel (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (2)

Endocrinology (1)

Inflammation/Immunology (1)

Neurological Disease (14)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145514C

dTAGV-1 hydrochloride 5 Publications Verification	FKBP PROTACs	Cancer
dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12 ^F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12 ^F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A)) .

HY-101374A

AGN 192403 hydrochloride (+)-BRD4780	Imidazoline Receptor Caspase Mitochondrial Metabolism Lactate Dehydrogenase	Cardiovascular Disease Neurological Disease Cancer
AGN 192403 (BRD4780) hydrochloride is a potent and selective imidazoline-1 receptor antagonist with a K_i value of 42 nM. AGN 192403 hydrochloride is also a TMED9 inhibitor. AGN 192403 hydrochloride shows protective effects on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. AGN 192403 hydrochloride mitigates the proliferation and migration of differentiated glioma tumor cells. AGN 192403 hydrochloride can be used for glioma tumor and neurological diseases research .

HY-107922

Ethopropazine hydrochloride 1 Publications Verification Isothazine	Cholinesterase (ChE) iGluR mAChR	Neurological Disease
Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease .

HY-B0194A

Tizanidine hydrochloride	Adrenergic Receptor Apoptosis Akt Wnt β-catenin	Neurological Disease Endocrinology Cancer
Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI) .

HY-W250727

TNS sodium 1 Publications Verification 6-(p-Tolylamino)naphthalene-2-sulfonate sodium	Fluorescent Dye	Others
TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

HY-126534A

Abemaciclib metabolite M18 hydrochloride 2 Publications Verification LSN3106729 Hydrochloride	Ligands for Target Protein for PROTAC CDK	Cancer
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .

HY-W012161

Alanylphenylalanine L-Alanyl-L-phenylalanine; H-Ala-Phe-OH	Endogenous Metabolite Drug Intermediate	Others
Alanylphenylalanine (L-Alanyl-L-phenylalanine) is a dipeptide. Alanylphenylalanine forms a mononuclear Au (III) complex through bidentate coordination via its carboxyl oxygen atom and deprotonated amide nitrogen atom .

HY-U00443

SB 258719	5-HT Receptor	Neurological Disease Cancer
SB 258719 is a selective 5-HT₇ receptor antagonist with high affinity (pK_i=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease .

HY-Y0024

4-Methoxyacetophenone	Environmental Pollutants Drug Intermediate	Others
4-Methoxyacetophenone is a versatile aromatic ketone that is widely used in the synthesis of various organic compounds. 4-Methoxyacetophenone has a pleasant aroma and can be used to create scents. 4-Methoxyacetophenone can also be used to make dyes and pigments .

HY-W145090

4-Dimethylaminopyridine N-oxide p-Dimethylaminopyridine N-oxide	Biochemical Assay Reagents	Others
4-Dimethylaminopyridine N-oxide (p-Dimethylaminopyridine N-oxide) is an Efficient Oxidizing Agent for Alkyl Halides .

HY-103123

SB 258719 hydrochloride	5-HT Receptor	Neurological Disease Cancer
SB 258719 hydrochloride is a selective 5-HT₇ receptor antagonist displayed high affnity (pK_i=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases .

HY-A0236A

Aprindine hydrochloride	Sodium Channel Potassium Channel Calcium Channel Calmodulin	Cardiovascular Disease
Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (I_Na), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na ⁺/Ca ²⁺ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias .

HY-101100

Anpirtoline hydrochloride D-16949 Hydrochloride	5-HT Receptor	Neurological Disease
Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT_1B receptor agonist, with K_is of 28 nM (5-HT_1B), 150 nM (5-HT_1A) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects .

HY-19562A

PF-06260933 hydrochloride 4 Publications Verification	MAP4K	Inflammation/Immunology
PF-06260933 hydrochloride is the hydrochloride form of PF-06260933 (HY-19562). PF-06260933 hydrochloride is an orally active and highly selective inhibitor of MAP4K4 with IC₅₀s of 3.7 and 160 nM for kinase and cell, respectively .

HY-114549

(R)-SCH-23982 hydrochloride	Dopamine Receptor	Neurological Disease
(R)-SCH-23982 hydrochloride is the R-enantiomer of SCH-23982 hydrochloride. SCH-23982 hydrochloride is a selective dopamine D1 receptor antagonist. (R)-SCH-23982 hydrochloride is promising for research of central nervous system disorders such as schizophrenia, Parkinson’s disease .

HY-138813

N-Desethyl Sunitinib hydrochloride Maximum Cited Publications 6 Publications Verification SU-12662 Hydrochloride	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

HY-N1777

3,4-Dimethoxybenzamide	Drug Intermediate	Others
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

HY-103376

NBI-27914 hydrochloride	CRFR	Neurological Disease
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a K_i value of 1.7 nM .

HY-101820A

Simotinib hydrochloride	EGFR	Cancer
Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC₅₀ of 19.9 nM. Antineoplastic activities .

HY-116459

trans-Cevimeline hydrochloride AF102A Hydrochloride	mAChR	Neurological Disease
Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease .

HY-W013776

meta-Fluoxetine hydrochloride	Serotonin Transporter Autophagy 5-HT Receptor	Neurological Disease Cancer
meta-Fluoxetine hydrochloride is the isomer of Fluoxetine hydrochloride (HY-B0102A). meta-Fluoxetine hydrochloride is a weak serotonin selective reuptake inhibitor (SSRI) .

HY-103425

JHW007 hydrochloride	Dopamine Receptor	Neurological Disease
JHW007 hydrochloride is the hydrochloride of JHW007. JHW007 is an antagonist of cocaine .

HY-N9910

Visamminol	Endogenous Metabolite	Others
Visamminol is a spasmolytic which can be extracted from Cimicifuga dahurica. Visamminol exhibits a spasmolytic action that is one-third as potent as that of papaverine hydrochloride .

HY-138813R

N-Desethyl Sunitinib hydrochloride (Standard) SU-12662 Hydrochloride (Standard)	Reference Standards Drug Metabolite	Cancer
Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-107922R

Ethopropazine hydrochloride (Standard) Isothazine (Standard)	Reference Standards Cholinesterase (ChE) iGluR mAChR	Neurological Disease
Ethopropazine (hydrochloride) (Standard) is the analytical standard of Ethopropazine (hydrochloride) (HY-107922). This product is intended for research and analytical applications. Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease .

HY-W573558

(tert-Butoxycarbonyl)-DL-glutamine	Drug Intermediate	Neurological Disease
(tert-Butoxycarbonyl)-DL-glutamine (Compound 2I) is a tert-butoxycarbonyl-protected glutamine derivative. (tert-Butoxycarbonyl)-DL-glutamine can be used for the synthesis of N-BOC-L-glutamine esters and Apocynin (HY-N0088). (tert-Butoxycarbonyl)-DL-glutamine is applicable to the research of retinal degenerative diseases .

HY-W724128

Cariprazine N-oxide	Drug Derivative	Neurological Disease
Cariprazine N-oxide (Compound DP-3) is the mono-oxidative degradation product of Cariprazine hydrochloride (HY-14763A). Cariprazine hydrochloride exhibits antipsychotic activity .

HY-N1777R

3,4-Dimethoxybenzamide (Standard)	Reference Standards Drug Intermediate	Others
3,4-Dimethoxybenzamide (Standard) is the analytical standard of 3,4-Dimethoxybenzamide. This product is intended for research and analytical applications. 3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride[1][2].

HY-P11692

Fmoc-Aeg-OtBu	Drug Intermediate	Others
Fmoc-Aeg-OtBu is an intermediate in solid-phase peptide synthesis, and serves as a building block for introducing pseudoproline motifs or backbone modifications .

HY-W099812

Methyl 2-aminopentanoate (hydrochloride) H-DL-Nva-OMe (Hydrochloride)	Biochemical Assay Reagents	Others
Methyl 2-aminopentanoate hydrochloride (H-DL-Nva-OMe hydrochloride) is a chiral α-amino ester hydrochloride precursor used for the synthesis of N-Boc-protected α-amino aldehyde 2b .

Cat. No.	Product Name	Type

HY-W250727

TNS sodium 1 Publications Verification 6-(p-Tolylamino)naphthalene-2-sulfonate sodium	Biochemical Assay Reagents
TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

TNS sodium

1 Publications Verification

6-(p-Tolylamino)naphthalene-2-sulfonate sodium

Biochemical Assay Reagents

TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively .

HY-Y0024

4-Methoxyacetophenone	Biochemical Assay Reagents
4-Methoxyacetophenone is a versatile aromatic ketone that is widely used in the synthesis of various organic compounds. 4-Methoxyacetophenone has a pleasant aroma and can be used to create scents. 4-Methoxyacetophenone can also be used to make dyes and pigments .

Cat. No.	Product Name	Target	Research Area

HY-P11692

Fmoc-Aeg-OtBu	Drug Intermediate	Others
Fmoc-Aeg-OtBu is an intermediate in solid-phase peptide synthesis, and serves as a building block for introducing pseudoproline motifs or backbone modifications .

Alanylphenylalanine L-Alanyl-L-phenylalanine; H-Ala-Phe-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
Alanylphenylalanine (L-Alanyl-L-phenylalanine) is a dipeptide. Alanylphenylalanine forms a mononuclear Au (III) complex through bidentate coordination via its carboxyl oxygen atom and deprotonated amide nitrogen atom .

3,4-Dimethoxybenzamide	Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Drug Intermediate
3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride .

Visamminol	Ketones, Aldehydes, Acids Artemisia cana Pursh Umbelliferae Plants Source Classification	Endogenous Metabolite
Visamminol is a spasmolytic which can be extracted from Cimicifuga dahurica. Visamminol exhibits a spasmolytic action that is one-third as potent as that of papaverine hydrochloride .

3,4-Dimethoxybenzamide (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Drug Intermediate
3,4-Dimethoxybenzamide (Standard) is the analytical standard of 3,4-Dimethoxybenzamide. This product is intended for research and analytical applications. 3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride[1][2].

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Hydrochloride

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