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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
Ileum contraction
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "Ileum contraction" in MCE Product Catalog:
Referencia número: HY-P0242
No. CAS: 86933-75-7
Referencia número: HY-P0242A
No. CAS: 101536-55-4
Áreas de investigación:
Cardiovascular Disease Inflammation/Immunology Endocrinology
Referencia número: HY-153508
No. CAS: 2098490-06-1
Target:
Áreas de investigación:
ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum .
Referencia número: HY-169450
No. CAS: 425623-55-8
Synonyms: 9-O-Desmethyl mitragynine
Target:
Áreas de investigación:
(-)-9-Hydroxycorynantheidine (9-O-Desmethyl mitragynine), the 9-demethyl analogue of Mitragynine, is a selective and partial agonist of μ-opioid receptor. (-)-9-Hydroxycorynantheidine inhibits electrically stimulated twitch contraction in guinea-pig ileum .
Referencia número: HY-134092
No. CAS: 131391-65-6
Synonyms: N-Methyl-LTC4
Target:
Áreas de investigación:
N-Methyl Leukotriene C4 (N-Methyl-LTC4) is a non-metabolizable LTC4 analog and a selective cysteinyl leukotriene receptor 2 (CysLT2) agonist, with an EC50 of 46.1 nM for mouse CysLT2 and an EC50 value of 122.3 nM for human CysLT2. N-Methyl Leukotriene C4 shows low potency against CysLT1. N-Methyl Leukotriene C4 activates human and mouse CysLT2 receptors, triggering calcium signaling, β-arrestin-2 binding to phosphorylated receptors, vascular leakage, hypotension, tachycardia, contraction of guinea pig ileum and trachea, mild bronchoconstriction, as well as hypertension associated with peripheral vasoconstriction. N-Methyl Leukotriene C4 can be used in research on asthma, rhinitis, sinusitis, cerebral inflammation and edema, pulmonary arterial hypertension, and cardiovascular diseases .
Referencia número: HY-120927A
No. CAS: 170098-43-8
Target:
Áreas de investigación:
Alvimopan metabolite hydrochloride is a peripherally restricted Opioid Receptor antagonist that inhibits the amplitude of electrically evoked contractions and spontaneous mechanical activity in guinea pig ileum .
Referencia número: HY-101946
No. CAS: 108427-72-1
Target:
Áreas de investigación:
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.
Referencia número: HY-P10599
No. CAS: 103425-21-4
Target:
Áreas de investigación:
Referencia número: HY-167825
No. CAS: 24506-68-1
Referencia número: HY-111918
No. CAS: 127902-33-4
Target:
Áreas de investigación:
A71378 is a selectivity CCK-A receptor agonist the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM) .
Referencia número: HY-121020
No. CAS: 83162-82-7
Target:
Referencia número: HY-130138A
No. CAS: 82948-88-7
Target:
Áreas de investigación:
(5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .
Referencia número: HY-113758
No. CAS: 97581-70-9
Target:
Áreas de investigación:
LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4 .
Referencia número: HY-130138B
No. CAS: 129263-59-8
Synonyms: (5S,6R)-(11E)-DiHETE
Target:
Áreas de investigación:
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .
Referencia número: HY-U00127
No. CAS: 147493-44-5
Target:
Áreas de investigación:
Pyridazinediones-derivative-1 has potential in treating neurodegenerative disorders. It shows an ED50 of 2.1 μM for inhibiting glutamate-induced contractions of isolated guineapig ileum.
Referencia número: HY-P10006
No. CAS: 88846-98-4
Target:
Áreas de investigación:
Referencia número: HY-136947
No. CAS: 91556-75-1
Target:
Áreas de investigación:
RJR-2429 is a nAChR agonist (EC50: 59 nM). RJR-2429 binds with high affinity to α4β2 receptor subtype (Ki = 1 nM). RJR-2429 induces ileum contraction .
Referencia número: HY-W747554
No. CAS: 155059-55-5
Target:
Áreas de investigación:
SM 32 is an analgesic. SM 32 produces an increase in ACh release. SM 32 amplifies electrically- and nicotine- evoked guinea-pig ileum contractions. SM32 induces antinociceptive effects through a central cholinergic mechanism .
Referencia número: HY-112707
No. CAS: 3032946-55-4
Target:
Áreas de investigación:
AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. AM9405 inhibits twitch contraction of the ileum and the colon with IC50s of 45.71 and 0.076 nM, respectively.
Referencia número: HY-130432
No. CAS: 195211-53-1
Target:
Áreas de investigación:
DBO-83 dihydrochloride is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 dihydrochloride activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 dihydrochloride shows antinociceptive and anti-amnesic activities .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
