2098490-06-1
Chemical Structure
ANO1-IN-4
- CAS No.: 2098490-06-1
- Formula:C19H19BrF2N2O2S
- Molecular Weight:457.33
IUPAC Name: 2-(2-bromo-2,2-difluoroacetamido)-N-(o-tolyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
InChIKey: VLFFBQAZZDJCHK-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC(C(F)(Br)F)=O)SC2=C1CCCCC2)NC3=C(C)C=CC=C3
Biological Activity: ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum[1].
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ANO1-IN-4 | 99.58% | ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC50 of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum. | ||||||||||||||||||||
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Keywords
