83162-82-7
Chemical Structure
Arcapillin
- CAS No.: 83162-82-7
- Formula:C18H16O8
- Molecular Weight:360.31
IUPAC Name: 2-(2,4-dihydroxy-5-methoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-chromen-4-one
InChIKey: IZWKTABKAJGBFW-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC(OC)=C(O)C=C2O)OC3=CC(OC)=C(OC)C(O)=C13
Biological Activity: Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 Mpro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS)[1][2].
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Arcapillin | Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 Mpro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS). | |||||||||||||||||||||
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- [1]. Abu-Niaaj L, et al. Evaluation of Antispasmodic Effect of Arcapillin on Smooth Muscles of Rats. Pharmacogn J. 2019 July 15;11(4):712-717.
- [2]. Badawy AM, et al. Dual SARS-CoV-2 and MERS-CoV inhibitors from Artemisia monosperma: isolation, structure elucidation, molecular modelling studies, and in vitro activities. Org Biomol Chem. 2024 Aug 28;22(34):7006-7016. [Content Brief]
Keywords
