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Imipenem

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (5) Apoptosis (1) Bacterial (14) Beta-lactamase (11) Isotope-Labeled Compounds (1) Reference Standards (2)
By Research Areas:	Cancer (1) Infection (17) Inflammation/Immunology (2)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1369A

*Imipenem* Maximum Cited Publications 35 Publications Verification N-Formimidoyl thienamycin; MK0787	Antibiotic Bacterial	Infection
Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-B1369

Imipenem monohydrate 30+ Cited Publications N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate	Antibiotic Bacterial	Infection
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-16752

Relebactam 25+ Cited Publications MK-7655	Beta-lactamase Bacterial	Infection
Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .

HY-W561907

IMipenem and cilastatin sodium	Antibiotic Bacterial	Infection
IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine .

HY-B1369R

Imipenem monohydrate (Standard) N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)	Reference Standards Antibiotic Bacterial	Infection
Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-16752R

Relebactam (Standard) MK-7655 (Standard)	Beta-lactamase Reference Standards Bacterial	Infection
Relebactam (Standard) is the analytical standard of Relebactam. This product is intended for research and analytical applications. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .

HY-148790

Pralurbactam FL058	Bacterial Beta-lactamase	Infection
Pralurbactam (FL058) is a β-lactamase (Beta-lactamase) inhibitor. Pralurbactam enhances the antibacterial activity of Imipenem against Mycobacterium abscessus. Pralurbactam reduces the pulmonary bacterial load in neutropenic mice infected with Mycobacterium abscessus. Pralurbactam can be used in research related to infections caused by Mycobacterium abscessus complex, Escherichia coli, and Klebsiella pneumoniae .

HY-125604

WCK-4234	Beta-lactamase Bacterial	Infection Inflammation/Immunology
WCK-4234 is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 lacks direct antibacterial activity. WCK-4234 inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections .

HY-144659

Metallo-β-lactamase-IN-5	Beta-lactamase Apoptosis Bacterial	Infection
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC₅₀ of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .

HY-B1369AS

Imipenem-d4 N-Formimidoyl thienamycin-d₄; MK0787-d₄	Isotope-Labeled Compounds	Infection
Imipenem-d₄ (N-Formimidoyl thienamycin-d₄) is a deuterium labeled Imipenem (HY-B1369A). Imipenem is an antibiotic .

HY-175724

MBL-IN-6	Beta-lactamase Bacterial	Infection
MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with K_is of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research .

HY-16752A

Relebactam sodium MK-7655 sodium	Beta-lactamase Bacterial	Infection
Relebactam sodium (MK-7655 sodium) is a potent and selective β-lactamase inhibitor with the activity of delaying the development of bacterial resistance to antibiotics. Relebactam sodium can bind to a variety of β-lactamases, thereby improving the efficacy of β-lactam antibiotics. Relebactam sodium shows good application potential in inhibiting complicated bacterial infections .

HY-152105

Metallo-β-lactamase-IN-9	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC₅₀s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively .

HY-128049

ML121	Beta-lactamase	Infection
ML121 is a selective and potent VIM-2 inhibitor with an IC₅₀ of 54 nM and a K_i of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli .

HY-173472

MBL-IN-5	Bacterial Beta-lactamase	Infection
MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC₅₀s of 0.05  nM, 14  nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic .

HY-113703

PD117588	Antibiotic	Cancer
PD117588 is a quinolone antibacterial agent with a broad range of antibacterial activity. PD117588 exhibits excellent activity against a variety of Gram-positive and Gram-negative bacteria from cancer patients, especially against all Gram-positive strains, including methicillin-resistant Staphylococcus aureus, coagulase-negative Staphylococci, and Enterococci. PD117588 is also very effective against most Gram-negative bacilli, although ciprofloxacin shows stronger activity against Pseudomonas aeruginosa. Compared with other quinolone antibiotics, the minimum inhibitory concentration of PD117588 outperforms most of the tested microorganisms, including imipenem and ceftazidime .

HY-18704

Cyslabdan (+)-Cyslabdan	Others	Infection
Cyslabdan ((+)-Cyslabdan) is a novel compound with the potential to enhance the activity of imipenem against methicillin-resistant Staphylococcus aureus. Cyslabdan exerts its antibacterial effect by inhibiting the synthesis of pentapeptide cross-links .

HY-125604A

WCK-4234 free base	Beta-lactamase Bacterial	Infection Inflammation/Immunology
WCK-4234 free base is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 free base lacks direct antibacterial activity. WCK-4234 free base inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 free base can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1369

Imipenem monohydrate 30+ Cited Publications N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-B1369R

Imipenem monohydrate (Standard) N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Antibiotic Bacterial
Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .

HY-18704

Cyslabdan (+)-Cyslabdan	Natural Products Microorganisms Source Classification	Others
Cyslabdan ((+)-Cyslabdan) is a novel compound with the potential to enhance the activity of imipenem against methicillin-resistant Staphylococcus aureus. Cyslabdan exerts its antibacterial effect by inhibiting the synthesis of pentapeptide cross-links .

Cat. No.	Product Name	Chemical Structure

HY-B1369AS

Imipenem-d4
Imipenem-d₄ (N-Formimidoyl thienamycin-d₄) is a deuterium labeled Imipenem (HY-B1369A). Imipenem is an antibiotic .

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Imipenem

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Isotope-Labeled Compounds

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