1261396-26-2
Chemical Structure
Imipenem-d4
Synonym(s): N-Formimidoyl thienamycin-d4; MK0787-d4
- CAS No.: 1261396-26-2
- Formula:C12H13D4N3O4S
- Molecular Weight:303.37
IUPAC Name: 2-(4-(2-hydroxy-2-methylpropyl)phenyl)propanoic-3,3,3-d3 acid
InChIKey: ZSKVGTPCRGIANV-OZYAQZRRSA-N
SMILES: O=C(O)C(N1[C@@]([H])([C@H](C1=O)[C@@H](C)O)C2)=C2SC([2H])([2H])C([2H])([2H])NC=N
Biological Activity: Imipenem-d4 (N-Formimidoyl thienamycin-d4) is the deuterated-labeled Imipenem (HY-B1369A). Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Imipenem-d4 | Imipenem-d4 (N-Formimidoyl thienamycin-d4) is the deuterated-labeled Imipenem (HY-B1369A). Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Imipenem | 99.89% | Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808. [Content Brief]
- [2]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. [Content Brief]
- [3]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90. [Content Brief]
