Metallo-β-lactamase-IN-5
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity.
For research use only. We do not sell to patients.
- CAS No.: 1417737-65-5
- Formula: C19H16N4O3
- Molecular Weight:348.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
45 μg/mL
Compound: 5c
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Cytotoxicity against human HUVEC cells assessed as metabolic activity measured after 24 hrs by cell-titer blue assay
Cytotoxicity against human HUVEC cells assessed as metabolic activity measured after 24 hrs by cell-titer blue assay
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[PMID: 34865870] |
Chemical Information
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CAS No. 1417737-65-5
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Molecular Weight 348.36
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Formula C19H16N4O3
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SMILES
N#CCN(CC1=CC([N+]([O-])=O)=C2C=CC=NC2=C1O)CC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Metallo-β-lactamase-IN-5 Related Classifications
HY-144659 Related Classifications
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