1417737-65-5
1417737-65-5
Chemical Structure
Metallo-β-lactamase-IN-5
- CAS 番号: 1417737-65-5
- Formula:C19H16N4O3
- Molecular Weight:348.36
IUPAC Name: 2-(benzyl((8-hydroxy-5-nitroquinolin-7-yl)methyl)amino)acetonitrile
InChIKey: CJFJGNGFFLNDIH-UHFFFAOYSA-N
SMILES: N#CCN(CC1=CC([N+]([O-])=O)=C2C=CC=NC2=C1O)CC3=CC=CC=C3
Biological Activity: Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].
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Metallo-β-lactamase-IN-5 | Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity. | |||||||||||||||||||||
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