2876921-34-3
2876921-34-3
Chemical Structure
MBL-IN-5
- CAS No.: 2876921-34-3
- Formula:C20H16ClNO3
- Molecular Weight:353.80
SMILES: O=C(C1=C(C2=C(OC)C=CC(Cl)=C2)C3=C(C4=C(CC3)C=CC=C4)N1)O
Biological Activity: MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05 nM, 14 nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic[1].
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MBL-IN-5 | MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC50s of 0.05 nM, 14 nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic. | |||||||||||||||||||||
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