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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Irbesartan
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Irbesartan" in MCE Product Catalog:
8
Target:
Research Areas:
Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
Cat. No.: HY-B0202S1
Cat. No.: HY-B0202S
CAS No.: 1216883-23-6
Synonyms: SR-47436-d4; BMS-186295-d4
Cat. No.: HY-B0202A
CAS No.: 329055-23-4
Synonyms: SR-47436 hydrochloride; BMS-186295 hydrochloride
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
Cat. No.: HY-B0202S2
CAS No.: 2375621-21-7
Cat. No.: HY-B0202R
CAS No.: 138402-11-6
Synonyms: SR-47436 (Standard); BMS-186295 (Standard)
Research Areas:
Irbesartan (Standard) is the analytical standard of Irbesartan. This product is intended for research and analytical applications. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .
Cat. No.: HY-B0202AS
Synonyms: SR-47436-d7 hydrochloride; BMS-186295-d7 hydrochloride
Cat. No.: HY-143963S
Cat. No.: HY-143964S
Cat. No.: HY-B0202S3
Synonyms: SR-47436-d7; BMS-186295-d7
Cat. No.: HY-B0202S4
Synonyms: SR-47436-13C,d4; BMS-186295-13C,d4
Cat. No.: HY-W742056
CAS No.: 1346598-52-4
Synonyms: Irbesartan dimer impurity
Target:
Research Areas:
Irbesartan impurity 2 (Irbesartan dimer impurity) is an impurity of Irbesartan.
Cat. No.: HY-W013465
CAS No.: 151257-01-1
Target:
Research Areas:
Irbesartan impurity 6 hydrochloride is an impurity of Irbesartan hydrochloride.
Cat. No.: HY-100082
CAS No.: 748812-53-5
Target:
Research Areas:
Irbesartan impurity 3 is an impurity of Irbesartan.
Cat. No.: HY-W279301
CAS No.: 138401-24-8
Target:
Research Areas:
Irbesartan impurity 1 is an impurity of Irbesartan.
Cat. No.: HY-W674659
CAS No.: 886999-35-5
Target:
Research Areas:
Irbesartan impurity 8 is an impurity of Irbesartan.
Cat. No.: HY-W777356
CAS No.: 160205-58-3
Target:
Research Areas:
Irbesartan impurity 7 is an impurity of Irbesartan.
Cat. No.: HY-W141106
CAS No.: 209911-63-7
Synonyms: Losartan Dibromo Impurity
Target:
Research Areas:
Irbesartan impurity 4 (Losartan Dibromo Impurity) is an impurity of Irbesartan.
Cat. No.: HY-W744768
Cat. No.: HY-L949
1279 compounds
Spirocyclic compounds, with rigid 3D structures, high Fsp³ and strong conformational restriction, are highly privileged scaffolds in small-molecule drug screening. They overcome drawbacks of planar aromatic compounds such as poor solubility, high off-target risks and weak druggability. Their orthogonal bicyclic geometry fits well into protein pockets, improving target affinity, subtype selectivity, metabolic stability and membrane permeability, making them ideal for hit identification against kinases, GPCRs, PPIs and other targets.
Spirocyclic scaffolds have been widely applied in oncology, antivirals, hypertension and CNS diseases, leading to many approved drugs and clinical candidates. SAR studies show that spiro-atom chirality, ring size and heteroatom substitution dominate bioactivity and selectivity, with the scaffold mainly serving as a conformational anchor. Azaspirocycles, spirooxindoles and spirosteranes target GPCRs, kinases, MDM2-p53 and PPIs. Approved drugs including irbesartan, spironolactone and rolapitant confirm their druggability, while revumenib and SAR405838 show promise against undruggable targets.
The MCE Spirocyclic Druglike Library contains over 1,000 diverse, stereospecific molecules selected by Lipinski’s rules. It covers privileged cores such as azaspirocycles, oxaspirocycles and spirooxindoles. These molecules bear rich chiral centers and distinct 3D orientations, reducing non-specific binding and enhancing screening efficiency. Featuring novel scaffolds, the library offers a highly innovative starting point for drug discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
