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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
JARID1
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "JARID1" in MCE Product Catalog:
21
21 Publications Verification
Target:
Research Areas:
JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
8
8 Cited Publications
Target:
Research Areas:
KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels [1] .
5
5 Cited Publications
Target:
Research Areas:
GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members [1] .
3
Target:
Research Areas:
PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively [1].
2
2 Cited Publications
Target:
Research Areas:
CBB1007 trihydrochloride is a reversible and selective LSD1 inhibitor with an IC50 of 5.27 µM for human LSD1. CBB1007 trihydrochloride significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 trihydrochloride shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 trihydrochloride is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma [1] .
Cat. No.: HY-179610
CAS No.: 951971-87-2
Target:
Research Areas:
YU185530 is a JARID1 histone demethylase inhibitor [1].
Cat. No.: HY-146670
CAS No.: 1385101-10-9
Target:
Research Areas:
KDM5B-IN-3 (Compound 5) is a histone lysine specific demethylase 5B (KDM5B/JARID1B) inhibitor with an IC50 of 9.32 μM. KDM5B-IN-3 can be used for the research of gastric cancer [1].
Cat. No.: HY-15313
CAS No.: 1379573-92-8
Target:
Research Areas:
CBB1007 is a reversible and selective LSD1 inhibitor with an IC50 of 5.27 µM for human LSD1. CBB1007 significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma [1] .
Target:
Research Areas:
CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor with an IC50 of 5.27 µM for human LSD1. CBB1007 hydrochloride significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 hydrochloride shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 hydrochloride is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma [1] .
Cat. No.: HY-P702902
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: KDM5C; Protein SmcX; Prev. JARID1C; Jumonji, AT Rich Interactive Domain 1C; Prev. SMCX; JmjC Domain-Containing Protein SMCX; Prev. MRX13; Mental Retardation, X-Linked 13; DXS1272E; Smcy Homolog, X-Linked (Mouse); XE169; Smcx Homolog, X Chromosome; [Histon
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702875
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: KDM5A; Histone Demethylase JARID1A; Prev. RBBP2; RBP2; Prev. JARID1A; Jumonji, AT Rich Interactive Domain 1A (RBBP2-Like); Lysine-Specific Demethylase 5A; Jumonji, AT Rich Interactive Domain 1A (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P85482
Synonyms: DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain containing protein SMCX; Jumonji AT rich interactive domain 1C; Jumonji, AT rich interactive domain 1C; RBP2 like; Jumonji/ARID domain-containing protein 1C; KDM5C; KDM5C_HUMAN; Lysine; K; specific demethylase 5C; Lysine-specific demethylase 5C; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; rbp2 like protein; Selected cDNA on X; SMCX; Smcx homolog X chromosome; SmcX protein; SmcX protein; Smcy homolog X linked; XE169; Xe169 protein; Xe169 protein.
Cat. No.: HY-P703589
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KDM5A; Histone Demethylase JARID1A; Prev. RBBP2; RBP2; Prev. JARID1A; Jumonji, AT Rich Interactive Domain 1A (RBBP2-Like); Lysine-Specific Demethylase 5A; Jumonji, AT Rich Interactive Domain 1A (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5A; Jumonji, AT Rich Interactive Domain 1A; Jumonji/ARID Domain-Containing Protein 1A; Retinoblastoma Binding Protein 2; Lysine (K)-Specific Demethylase 5A; NEDEHC; Retinoblastoma-Binding Protein 2; Lysine Demethylase 5A; RBBP-2
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
