KDM5A Protein, Human
KDM5A Protein, Human is the recombinant human-derived KDM5A, expressed by E. coli , with tag Free labeled tag. ,
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
KDM5A Protein, Human is the recombinant human-derived KDM5A, expressed by E. coli , with tag Free labeled tag. ,
KDM5A is a histone demethylase that specifically targets histone H3 at 'Lys-4', playing a pivotal role in histone code regulation. It does not act on H3 'Lys-9', 'Lys-27', 'Lys-36', 'Lys-79' or H4 'Lys-20', and only demethylates trimethylated/dimethylated (not monomethylated) H3 'Lys-4'. It regulates gene transcription by binding to 5'-CCGCCC-3' DNA motifs, potentially enhancing nuclear receptor-mediated transcription and modulating Hox protein expression during cell differentiation. KDM5A also represses cytokine transcription (e.g., CXCL12) and maintains circadian rhythm periodicity. In a demethylase-independent manner, it coactivates CLOCK-BMAL1-driven transcription of PER1/2 and clock-controlled genes by inhibiting HDAC1 to increase histone acetylation at PER1/2 promoters (By similarity). Evidence suggests it may act as a corepressor for genes like MT1F and promote cancer cell proliferation.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P29375-1 (M1-T588, del L88-K347)
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Gene ID5927
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Protein Length
Partial
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Synonyms
KDM5A; Histone Demethylase JARID1A; Prev. RBBP2; RBP2; Prev. JARID1A; Jumonji, AT Rich Interactive Domain 1A (RBBP2-Like); Lysine-Specific Demethylase 5A; Jumonji, AT Rich Interactive Domain 1A (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5
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Predicted Molecular Mass
37.7 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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