1628332-52-4
1628332-52-4
Chemical Structure
GSK467
- CAS No.: 1628332-52-4
- Formula:C17H13N5O2
- Molecular Weight:319.32
IUPAC Name: 2-((1-benzyl-1H-pyrazol-4-yl)oxy)pyrido[3,4-d]pyrimidin-4(1H)-one
InChIKey: ZTYRLXUTLYBVHH-UHFFFAOYSA-N
SMILES: O=C1C2=C(NC(OC3=CN(N=C3)CC4=CC=CC=C4)=N1)C=NC=C2
Biological Activity: GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK467 | 99.34% | GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.54
HY-178041BRD4-BD1/2-IN-3 -
Similarity Score 0.52
HY-117391AZ-Dyrk1B-33 -
Similarity Score 0.50
HY-101462RRAD51 Inhibitor B02 (Standard) -
Similarity Score 0.50
HY-W482839Glycosminine -
Similarity Score 0.49
HY-W024067WAY-608119 -
Similarity Score 0.49
HY-W0756174,4'-(1-Benzyl-1H-1,2,4-triazole-3,5-diyl)dipyridine -
Similarity Score 0.49
HY-156863GRK2 Inhibitor 2 -
Similarity Score 0.48
HY-143235BRD4 Inhibitor-15 -
Similarity Score 0.48
HY-168897LC3B ligand 1 -
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