Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Janus kinase 3
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Janus kinase 3" in MCE Product Catalog:
Target:
Research Areas:
JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM.
Cat. No.: HY-119935
CAS No.: 2300106-50-5
Target:
Research Areas:
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs .
Cat. No.: HY-172432
CAS No.: 2360992-48-7
Target:
Research Areas:
Plodicitinib is a Janus tyrosine kinase 3/TEC family kinase inhibitor with anti-inflammatory activity .
Cat. No.: HY-W740378
CAS No.: 220038-19-7
Synonyms: AFN-941
1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).
Cat. No.: HY-161618
CAS No.: 2099014-23-8
Research Areas:
MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg) .
Cat. No.: HY-15163A
CAS No.: 1354567-82-0
Zotiraciclib hydrochloride is a novel small molecule multi-target enzyme inhibitor with activity in inhibiting tumor growth. Zotiraciclib hydrochloride exerts its anti-tumor effect by reducing the level of Myc through inhibiting cyclin-dependent kinase 9 (CDK9). Zotiraciclib hydrochloride may be useful for inhibiting cancers that cross the blood-brain barrier. The high protein level of MCL-1 of Zotiraciclib hydrochloride is associated with survival, suggesting that it may serve as a prognostic factor and inhibitory target in further studies .
Cat. No.: HY-P702721
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: JAK3; JAK3_HUMAN; Janus kinase 3; JAKL; L-JAK; LJAK; JAK-3; Janus kinase 3 (A Protein Tyrosine kinase, Leukocyte); Tyrosine-Protein kinase JAK3; Tyrosine-Protein kinase; Leukocyte Janus kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705710
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAK3; JAK3_HUMAN; Janus kinase 3; JAKL; L-JAK; LJAK; JAK-3; Janus kinase 3 (A Protein Tyrosine kinase, Leukocyte); Tyrosine-Protein kinase JAK3; Tyrosine-Protein kinase; Leukocyte Janus kinase
Species:
Human
Source:
Sf9 insect cells
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
