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Results for "

Janus kinase 3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	JAK (5) CDK (1) EGFR (2) FLT3 (1) GSK-3 (1) IGF-1R (1) PI3K (1) Tyrosinase (1)
By Research Areas:	Cancer (1) Endocrinology (1) Inflammation/Immunology (4)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: JAK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101976

JAK3-IN-6	JAK	Inflammation/Immunology
JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC₅₀ of 0.15 nM.

HY-119935

JAK3 covalent inhibitor-1	JAK	Inflammation/Immunology
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC₅₀ of 11 nM and shows 246-fold selectivity vs other JAKs .

HY-172432

Plodicitinib	Tyrosinase	Inflammation/Immunology
Plodicitinib is a **Janus tyrosine kinase 3/TEC** family kinase inhibitor with anti-inflammatory activity .

HY-W740378

1,2,3,4-Tetrahydro Staurosporin AFN-941	EGFR JAK	Others
1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC₅₀=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC₅₀=390 nM). It also binds to Janus kinase 3 (JAK3).

HY-161618

MJ04	JAK EGFR PI3K IGF-1R GSK-3	Inflammation/Immunology Endocrinology
MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC₅₀ of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD₅₀ >2 g/kg) .

HY-15163A

Zotiraciclib hydrochloride	FLT3 JAK CDK	Cancer
Zotiraciclib hydrochloride is a novel small molecule multi-target enzyme inhibitor with activity in inhibiting tumor growth. Zotiraciclib hydrochloride exerts its anti-tumor effect by reducing the level of Myc through inhibiting cyclin-dependent kinase 9 (CDK9). Zotiraciclib hydrochloride may be useful for inhibiting cancers that cross the blood-brain barrier. The high protein level of MCL-1 of Zotiraciclib hydrochloride is associated with survival, suggesting that it may serve as a prognostic factor and inhibitory target in further studies .

Recombinant Proteins Recommended:

Janus Kinase 3

Species:	Human (2)
Tag:	His (1) Avi (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702721

	JAK3 Protein, Human (Active, sf9, GST) JAK3; Janus kinase 3; tyrosine-protein kinase JAK3; JAK 3; JAK3_HUMAN; JAKL; L JAK; leukocyte Janus kinase; LJAK; tyrosine protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); JAK-3; L-JAK	Human	Sf9 insect cells
	JAK3 Protein, Human (sf9, GST) is the recombinant human-derived JAK3, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P705710

	JAK3 Protein, Human (Biotinylated, Inactive, sf9, Avi-His) Tyrosine-protein kinase JAK3; EC:2.7.10.2; Janus kinase 3 (JAK-3); Leukocyte Janus kinase (L-JAK); JAK3	Human	Sf9 insect cells

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Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (4) Rat (1) Mouse (1)
Application:	IHC-P (2) ICC/IF (3) IF-Tissue (1) IP (1) IHC-F (1) WB (3) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (4) Biotin (1)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85716

	JAK3 Antibody (YA5408) Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; Leukocyte Janus kinase; L-JAK;	IHC-P	Human, Mouse, Rat
	JAK3 Antibody (YA5408) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to JAK3.

HY-P82721

	JAK3 Antibody (YA2466) JAK3; Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; Leukocyte Janus kinase; L-JAK	WB, ICC/IF	Human
	JAK3 Antibody (YA2466) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JAK3.

HY-P85234

	JAK3 Antibody (YA4926) JAK3; Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; Leukocyte Janus kinase; L-JAK	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human
	JAK3 Antibody (YA4926) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to JAK3.

HY-P86474

	JAK3 Antibody (YA6166) JAK3; Tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; Leukocyte Janus kinase; L-JAK	WB, ICC/IF, IP, ELISA	Human
	JAK3 Antibody (YA6166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JAK3.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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