1,2,3,4-Tetrahydro Staurosporin (Synonyms: AFN-941)

Cat. No.: HY-W740378: Data Sheet Handling Instructions
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1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC₅₀=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC₅₀=390 nM). It also binds to Janus kinase 3 (JAK3).

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1,2,3,4-Tetrahydro Staurosporin 화학구조

CAS No. : 220038-19-7

사이즈	재고	수량
1 mg	견적 받기 2 - 3 weeks 4 - 5 weeks 5 - 6 weeks 1 - 2 weeks	Estimated Time of Arrival: December 31
5 mg	견적 받기
10 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
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고객리뷰

제품 설명	1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC₅₀=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC₅₀=390 nM). It also binds to Janus kinase 3 (JAK3).
분자량	470.56
화학식	C₂₈H₃₀N₄O₃
CAS No.	220038-19-7
SMILES	C[C@@]12[C@H](OC)[C@H](NC)C[C@@H](O1)N3C4=C(C5=C3C6=C(C7=C5C(NC7)=O)C8=CC=CC=C8N62)CCCC4
선적	Room temperature in continental US; may vary elsewhere.
보관	Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서	Data Sheet (279 KB) Handling Instructions (2659 KB)
References	[1]. Song, et al. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4):e2590,(2017).

1,2,3,4-Tetrahydro Staurosporin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,2,3,4-Tetrahydro Staurosporin220038-19-7AFN-941AFN941AFN 941EGFRJAKEpidermal growth factor receptorErbB-1HER1Janus kinaseInhibitorinhibitorinhibit

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1,2,3,4-Tetrahydro Staurosporin (Synonyms: AFN-941)

1,2,3,4-Tetrahydro Staurosporin Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All EGFR Isoform Specific Products:

View All JAK Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

1,2,3,4-Tetrahydro Staurosporin Related Classifications

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