1,2,3,4-Tetrahydro Staurosporin
1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).
For research use only. We do not sell to patients.
- CAS No.: 220038-19-7
- Formula: C₂₈H₃₀N₄O₃
- Molecular Weight:470.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
Description
Chemical Information
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CAS No. 220038-19-7
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Molecular Weight 470.56
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Formula C₂₈H₃₀N₄O₃
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SMILES
C[C@@]12[C@H](OC)[C@H](NC)C[C@@H](O1)N3C4=C(C5=C3C6=C(C7=C5C(NC7)=O)C8=CC=CC=C8N62)CCCC4
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Synonyms
AFN-941
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)