220038-19-7
Chemical Structure
1,2,3,4-Tetrahydro Staurosporin
Synonym(s): AFN-941
- CAS No.: 220038-19-7
- Formula:
- Molecular Weight:470.56
IUPAC Name: (5R,7R,8R,9S)-8-methoxy-9-methyl-7-(methylamino)-1,2,3,4,6,7,8,9,14,15-decahydro-5H,16H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-16-one
InChIKey: KIZWKTROWIIMNN-FYTWVXJKSA-N
SMILES: C[C@@]12[C@H](OC)[C@H](NC)C[C@@H](O1)N3C4=C(C5=C3C6=C(C7=C5C(NC7)=O)C8=CC=CC=C8N62)CCCC4
Biological Activity: 1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).
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1,2,3,4-Tetrahydro Staurosporin | 1,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3). | |||||||||||||||||||||
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Keywords
