2099014-23-8
Chemical Structure
MJ04
- CAS No.: 2099014-23-8
- Formula:C20H16FN5
- Molecular Weight:345.37
InChIKey: IWEFQYFFHNADPN-UHFFFAOYSA-N
SMILES: FC1=CC=C(C2=CN=C(NC=C3C4=NC(NC5CC5)=NC=C4)C3=C2)C=C1
Biological Activity: MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MJ04 | 98.08% | MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
