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L-leucine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (22) Aminopeptidase (4) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (10) Carboxypeptidase (1) Drug Derivative (1) Drug Intermediate (3) Endogenous Metabolite (33) Fluorescent Dye (1) Isotope-Labeled Compounds (11) Ligands for E3 Ligase (1) mTOR (17) Phospholipase (1) Prolyl Endopeptidase (PREP) (1) Proteasome (2) Reference Standards (9) SOD (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (4) Metabolic Disease (32) Neurological Disease (10)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0486

*L-Leucine* 15+ Cited Publications leucine	mTOR Endogenous Metabolite Ligands for E3 Ligase	Metabolic Disease Cancer
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-129905

*L-Leucyl-L-Leucine* methyl ester hydrochloride** Maximum Cited Publications 18 Publications Verification LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

HY-129905A

*L-Leucyl-L-Leucine* methyl ester hydrobromide** Maximum Cited Publications 18 Publications Verification LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	Endogenous Metabolite	Inflammation/Immunology
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Endogenous Metabolite Autophagy mTOR SOD	Neurological Disease Metabolic Disease
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

HY-59291

Levacetylleucine N-Acetyl-L-leucine	Amino Acid Derivatives	Neurological Disease Metabolic Disease Inflammation/Immunology
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention .

HY-N0486R

L-Leucine (Standard) 1 Publications Verification leucine (Standard)	Reference Standards mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S9

L-Leucine-d3 3 Publications Verification	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S1

L-Leucine-13C	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W008642

Leu-Leu-OH L-Leucyl-L-leucine; Leu-Leu; H-Leu-Leu-OH	Amino Acid Derivatives	Metabolic Disease
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dye	Others
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-113221

Isovalerylcarnitine	Proteasome Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Isovalerylcarnitine is a metabolite of leucine. Isovalerylcarnitine can specifically activate calpain in human neutrophils. Isovalerylcarnitine inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine are negatively correlated with reduced lung cancer risk .

HY-N0486S

L-Leucine-d10 1 Publications Verification	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S2

L-Leucine-13C6	mTOR Endogenous Metabolite	Metabolic Disease
Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-Y0378

D-Leucine (R)-leucine	Endogenous Metabolite	Neurological Disease
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W012708

3-Amino-4-methylpentanoic acid	Endogenous Metabolite	Others
3-Amino-4-methylpentanoic acid is a β amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase. 3-Amino-4-methylpentanoic acid is also a metabolite produced by Torulaspora delbrueckii and can be used in the research of wine fermentation .

HY-N0486S8

L-Leucine-13C6,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S6

L-Leucine-2-13C,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W016077

Glycyl-L-leucine	Endogenous Metabolite	Others
Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.

HY-W040088

L-Alanyl-L-leucine H-Ala-Leu-OH	Aminopeptidase	Metabolic Disease
L-Alanyl-L-leucine is a competitive inhibitor of small intestinal *glycyl-L-leucine* hydrolase with K_i** values of 0.53 mM (phosphate buffer) or 0.22 mM (Tris buffer). L-Alanyl-L-leucine can be used for research on Hartnup disease and cystinuria .

HY-W068839

H-Phe-Leu-OH L-Phenylalanyl-L-leucine; Phe-Leu	Amino Acid Derivatives	Others
H-Phe-Leu-OH is a leucine derivative .

HY-W002303

L-Leucine benzyl ester p-toluenesulfonate	Amino Acid Derivatives	Others
L-Leucine benzyl ester p-toluenesulfonate is a leucine derivative .

HY-N0486S4

L-Leucine-d7	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S3

L-Leucine-15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-128434

L-Leucyl-L-alanine	Endogenous Metabolite	Metabolic Disease
L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

HY-W142035

N-Benzoyl-L-leucine	Amino Acid Derivatives	Others
N-Benzoyl-L-leucine is a leucine derivative .

HY-W010955

Z-Phe-Leu-OH NSC 334018	Carboxypeptidase	Others
Z-Phe-Leu-OH (NSC 334018) is a dipeptide acid. Z-Phe-Leu-OH undergoes hydrolysis by carboxypeptidase Y to release L-leucine. Z-Phe-Leu-OH acts as a substrate to assay carboxypeptidase Y peptidase activity .

HY-79404

N-(Tert-Butoxycarbonyl)-L-neopentylglycine L-leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl- (9CI); (S)-2-(tert-Butoxycarbonylamino)-4,4-dimethylpentanoic acid	Amino Acid Derivatives	Others
N-(Tert-Butoxycarbonyl)-L-neopentylglycine is a Glycine (HY-Y0966) derivative .

HY-122756

N-Palmitoyl-l-leucine GK144	Phospholipase	Inflammation/Immunology
N-Palmitoyl-l-leucine (GK144) is a secreted phospholipases A₂ inhibitor. N-Palmitoyl-l-leucine can be used for inflammatory diseases .

HY-W342021

Thr-Leu H-Thr-Leu-OH; L-Threonyl-L-leucine	Amino Acid Derivatives	Others
Thr-Leu is a dipeptide composed of threonine and leucine. Thr-Leu can be hydrolyzed in the peritoneal cavity to generate constituent amino acids, thereby increasing the osmotic pressure of the dialysate. Thr-Leu can be used for the kinetic study of amino acid-based peritoneal dialysis fluids .

HY-Y0378S

*D-Leucine-d10* (R)-leucine-d₁₀	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
D-Leucine-d₁₀ is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W002291

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Drug Derivative	Infection
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a fluorinated derivative of L-phenylalanine (HY-N0215). p-Fluoro-L-phenylalanine specifically binds to the L-leucine-specific receptor of Escherichia coli, with a K_d value of 0.26 μM .

HY-P2768

Leucine dehydrogenase, Microorganism LDH, EC 1.4.1.9	Endogenous Metabolite	Metabolic Disease
Leucine dehydrogenase, Microorganism (EC 1.4.1.9) can be purified from Bacillus spheroides. Leucine dehydrogenase catalyzed the oxidative deamination of L-leucine, L-valine, L-isoleucine, L-norvaline, L-alpha-aminobutyrate, and L-norleucine, and the reductive amination of their keto analogues .

HY-N0486S12

L-Leucine-d2	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S10

L-Leucine-18O2	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W009686

H-Pro-Leu-OH L-Prolyl-L-leucine; Pro-Leu	Amino Acid Derivatives	Others
H-Pro-Leu-OH is a leucine derivative .

HY-W040088R

*L-Alanyl-L-leucine* (Standard)** H-Ala-Leu-OH (Standard)	Reference Standards Aminopeptidase	Metabolic Disease
L-Alanyl-L-leucine is an endogenous metabolite. This product is used for research and analytical applications. L-Alanyl-L-leucine is a competitive inhibitor of small intestinal *glycyl-L-leucine* hydrolase with K_i** values of 0.53 mM (phosphate buffer) or 0.22 mM (Tris buffer). L-Alanyl-L-leucine can be used for research on Hartnup disease and cystinuria .

HY-137872

L-Leucyl-4-nitroanilide hydrochloride	Biochemical Assay Reagents	Others
L-Leucyl-4-nitroanilide hydrochloride is a commonly used substrate in various biochemical assays to measure the activity of enzymes that cleave peptide bonds, such as proteases. L-Leucine p-nitroanilide hydrochloride has unique chemical properties that allow it to be cleaved by these enzymes to form a yellow product called p-nitroaniline. This makes it a useful tool for detecting and quantifying protease activity in biological samples such as blood or tissue extracts.

HY-W419440

H-Lys-Leu-OH L-leucine, L-lysyl-	Biochemical Assay Reagents	Others
H-Lys-Leu-OH (L-Leucine, L-lysyl-) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W101495

Boc-Leu-OH hydrate N-Boc-L-leucine monohydrate	Amino Acid Derivatives	Others
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-I0616A

(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine	Drug Intermediate	Others
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine is a drug intermediate for synthesis of various active compounds.

HY-P2928

Aeromonas proteolytica aminopeptidase	Biochemical Assay Reagents Aminopeptidase	Others
Aeromonas proteolytica aminopeptidase is an aminopeptidase from Aeromonas proteolytica. Aeromonas proteolytica aminopeptidase can function as an esterase. Aeromonas proteolytica aminopeptidase can catalyze the hydrolysis of L-leucine ethyl ester (L-Leu-OEt) with a K_m of 700 µM .

HY-W002299

*Boc-D-Leucine* monohydrate** Boc-D-Leu-OH hydrate	Amino Acid Derivatives	Neurological Disease
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .

HY-N0486S11

L-Leucine-d1	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-137946

L-Leucine 4-methoxy-β-naphthylamide hydrochloride	Aminopeptidase	Others
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate .

HY-N0486S5

L-Leucine-2-13C	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S7

L-Leucine-1-13C,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-79415

4-Methyl-L-leucine L-leucine, 4-methyl- (9CI); L-2-Amino-4,4-dimethylpentanoic acid; L-γ-Methylleucine	Amino Acid Derivatives	Others
4-Methyl-L-leucine is a Glycine (HY-Y0966) derivative .

HY-122811

Dansyl-L-leucine Dansyl-L-leucine	Amino Acid Derivatives	Others
Dansyl-L-leucine is a leucine derivative .

HY-179875

N-Cholyl-L-leucine	Endogenous Metabolite	Metabolic Disease
N-Cholyl-L-leucine is a bile acid-amino acid conjugate, mainly produced by intestinal microorganisms. N-Cholyl-L-leucine can be used as a biomarker for premature infants and is also employed in the study of bile acid metabolism .

HY-Y0555

N-[(Phenylmethoxy)carbonyl]-L-leucine	Amino Acid Derivatives	Others
N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative .

Cat. No.	Product Name	Type

HY-W002291

p-Fluoro-L-phenylalanine 4-Fluoro-L-phenylalanine	Biochemical Assay Reagents
p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a fluorinated derivative of L-phenylalanine (HY-N0215). p-Fluoro-L-phenylalanine specifically binds to the L-leucine-specific receptor of Escherichia coli, with a K_d value of 0.26 μM .

HY-137872

L-Leucyl-4-nitroanilide hydrochloride

Biochemical Assay Reagents

L-Leucyl-4-nitroanilide hydrochloride is a commonly used substrate in various biochemical assays to measure the activity of enzymes that cleave peptide bonds, such as proteases. L-Leucine p-nitroanilide hydrochloride has unique chemical properties that allow it to be cleaved by these enzymes to form a yellow product called p-nitroaniline. This makes it a useful tool for detecting and quantifying protease activity in biological samples such as blood or tissue extracts.

HY-W557739

L-Leucine-7-amido-4-methylcoumarin	Biochemical Assay Reagents
L-Leucine-7-amido-4-methylcoumarin is a biochemical assay reagent.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0486

*L-Leucine* 15+ Cited Publications leucine	Structural Classification Metabolic Disease Amino acids Endogenous metabolite Source Classification	mTOR Endogenous Metabolite Ligands for E3 Ligase
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-129905

*L-Leucyl-L-Leucine* methyl ester hydrochloride** Maximum Cited Publications 18 Publications Verification LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .

HY-129905A

*L-Leucyl-L-Leucine* methyl ester hydrobromide** Maximum Cited Publications 18 Publications Verification LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Endogenous Metabolite Autophagy mTOR SOD
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

HY-59291

Levacetylleucine N-Acetyl-L-leucine	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Amino Acid Derivatives
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention .

HY-N0486R

L-Leucine (Standard) 1 Publications Verification leucine (Standard)	Structural Classification Zea mays L. Endocrine diseases Amino acids Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Gramineae Disease markers Nervous System Disorder Cardiovascular System Disorder Source Classification	Reference Standards mTOR Endogenous Metabolite
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W008642

Leu-Leu-OH L-Leucyl-L-leucine; Leu-Leu; H-Leu-Leu-OH	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Amino Acid Derivatives
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-113221

Isovalerylcarnitine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Proteasome Endogenous Metabolite Apoptosis
Isovalerylcarnitine is a metabolite of leucine. Isovalerylcarnitine can specifically activate calpain in human neutrophils. Isovalerylcarnitine inhibits tumor cell proliferation and induces apoptosis. Elevated circulating levels of Isovalerylcarnitine are negatively correlated with reduced lung cancer risk .

HY-Y0378

D-Leucine (R)-leucine	Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W012708

3-Amino-4-methylpentanoic acid	Classification of Application Fields Other Diseases Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Amino-4-methylpentanoic acid is a β amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase. 3-Amino-4-methylpentanoic acid is also a metabolite produced by Torulaspora delbrueckii and can be used in the research of wine fermentation .

HY-W016077

Glycyl-L-leucine	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.

HY-W040088

L-Alanyl-L-leucine H-Ala-Leu-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Aminopeptidase
L-Alanyl-L-leucine is a competitive inhibitor of small intestinal *glycyl-L-leucine* hydrolase with K_i** values of 0.53 mM (phosphate buffer) or 0.22 mM (Tris buffer). L-Alanyl-L-leucine can be used for research on Hartnup disease and cystinuria .

HY-128434

L-Leucyl-L-alanine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

HY-W040088R

*L-Alanyl-L-leucine* (Standard)** H-Ala-Leu-OH (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Aminopeptidase
L-Alanyl-L-leucine is an endogenous metabolite. This product is used for research and analytical applications. L-Alanyl-L-leucine is a competitive inhibitor of small intestinal *glycyl-L-leucine* hydrolase with K_i** values of 0.53 mM (phosphate buffer) or 0.22 mM (Tris buffer). L-Alanyl-L-leucine can be used for research on Hartnup disease and cystinuria .

HY-N14218

Eurystatin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Prolyl Endopeptidase (PREP)
Eurystatin A is a prolyl endopeptidase inhibitor, L-Leucine and L-Ornithine are the direct precursors of the L-Leucine and L-Ornithine moieties of eurystatins A .

HY-W012708R

3-Amino-4-methylpentanoic acid (Standard)	Structural Classification Amino acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
3-Amino-4-methylpentanoic acid is a β amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase. 3-Amino-4-methylpentanoic acid is also a metabolite produced by Torulaspora delbrueckii and can be used in the research of wine fermentation .

HY-128434R

L-Leucyl-L-alanine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
L-Leucyl-L-alanine (Standard) is the analytical standard of L-Leucyl-L-alanine (HY-128434). This product is intended for research and analytical applications. L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

HY-W016077R

*Glycyl-L-leucine* (Standard)**	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Glycyl-L-leucine (Standard) is the analytical standard of Glycyl-L-leucine. This product is intended for research and analytical applications. Glycyl-l-leucine is a dipeptide that can be a common substrate for glycyl-leucine dipeptidase.

HY-Y0378R

*D-Leucine* (Standard)** (R)-leucine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
D-Leucine (Standard) is the analytical standard of D-Leucine. This product is intended for research and analytical applications. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-W008642R

Leu-Leu-OH (Standard) L-Leucyl-L-leucine (Standard); Leu-Leu (Standard); H-Leu-Leu-OH (Standard)	Natural Products Endogenous metabolite Source Classification	Amino Acid Derivatives Reference Standards
Leu-Leu-OH (Standard) is the analytical standard of Leu-Leu-OH (HY-W008642). This product is intended for research and analytical applications. Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

Cat. No.	Product Name	Chemical Structure

HY-N0486S9

L-Leucine-d3 3 Publications Verification
L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S1

L-Leucine-13C
L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S

L-Leucine-d10 1 Publications Verification
L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S2

L-Leucine-13C6
Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S8

L-Leucine-13C6,15N
L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S6

L-Leucine-2-13C,15N
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S4

L-Leucine-d7
L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S3

L-Leucine-15N
L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-Y0378S

*D-Leucine-d10*
D-Leucine-d₁₀ is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro .

HY-N0486S12

L-Leucine-d2
L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S10

L-Leucine-18O2
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S11

L-Leucine-d1
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S5

L-Leucine-2-13C
L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S7

L-Leucine-1-13C,15N
L-Leucine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W012722BS

4-Methyl-2-oxopentanoic acid-d7 sodium

4-Methyl-2-oxopentanoic acid-d₇ (α-Ketoisocaproic acid-d₇) sodium is the deuterium labeled 4-Methyl-2-oxopentanoic acid (HY-W012722).4-Methyl-2-oxopentanoic acid is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways .

HY-N0486S13

L-Leucine-15N,d10
L-Leucine- ¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W101495S1

Boc-Leu-OH·H2O-d3
Boc-Leu-OH·H2O-d₃ is the deuterium labeled Boc-Leu-OH·H2O .

HY-W654243

Isovalerylcarnitine-d9-1 chloride
Isovalerylcarnitine-d₉-1 (chloride) is deuterium labeled Isovalerylcarnitine (chloride). Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-W008642S

(Leu-13C6,15N)-Leu-OH TFA
(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .

HY-W269700S

Ile-(Leu-13C6,15N)-OH TFA
Ile-(Leu-13C6,15N)-OH TFA is ¹³C- and ¹⁵N-labeled Ile-Leu-OH (HY-W269700). Ile-Leu-OH is a hydrophobic dipeptide fragment and is a component of the neurotensin C-terminal heptapeptide Pro-Arg-Arg-Pro-Tyr-Ile-LeuOH .

HY-W700927

*N-Formyl-L-leucine-d3*
N-Formyl-L-leucine-d₃ (N-Formyl-S-leucine-d₃) is deuterium labeled N-Formyl-L-leucine. N-Formyl-L-leucine is a leucine derivative .

HY-W340583S

*(2-(1H-indol-3-yl)acetyl)-L-leucine-d4*
(2-(1H-indol-3-yl)acetyl)-L-leucine-d₄ is deuterium labeled (2-(1H-indol-3-yl)acetyl)-L-leucine .

Cat. No.	Product Name		Classification

HY-N0486

*L-Leucine* 15+ Cited Publications leucine		Others
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

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