Isovalerylcarnitine

Name: Isovalerylcarnitine
Brand: MedChemExpress
SKU: HY-113221
Rating: 4.5 (1 reviews)

Cat. No.: HY-113221 Purity: ≥99.0%: Data Sheet
SDS

COA
Handling Instructions
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Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis.

For research use only. We do not sell to patients.

Isovalerylcarnitine Chemical Structure

CAS No. : 31023-24-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Isovalerylcarnitine:

Isovalerylcarnitine chloride In-stock
Isovalerylcarnitine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
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Description

Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis^[1]^[2]^[3].

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Isovalerylcarnitine produces an early and marked increase in phagocytosis and also in cell killing, as well as reduces proliferation, in U937 leukemic cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

245.32

Formula

C₁₂H₂₃NO₄

CAS No.

31023-24-2

Appearance

Solid

Color

White to off-white

SMILES

CC(C)CC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.76%

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Data Sheet (268 KB) SDS (251 KB)

COA (249 KB) HNMR (229 KB) RP-HPLC (240 KB) MS (79 KB)

Handling Instructions (2659 KB)

References

[1]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1189-95. [Content Brief]

[2]. Ferrara F, et al. Evaluation of carnitine, acetylcarnitine and isovalerylcarnitine on immune function and apoptosis. Drugs Exp Clin Res. 2005;31(3):109-14. [Content Brief]

[3]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of the high calcium requiring calpain forms. Biochem Biophys Res Commun. 1990 Feb 28;167(1):373-80. [Content Brief]