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LD50

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By Research Areas:	Cancer (38) Cardiovascular Disease (6) Endocrinology (2) Infection (49) Inflammation/Immunology (20) Metabolic Disease (6) Neurological Disease (11)
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118

Inhibitors & Agonists

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Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1275

N-Methylpyrrolidone NMP; 1-Methyl-2-pyrrolidinone	Environmental Pollutants Biochemical Assay Reagents	Cancer
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a *LD₅₀* value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-W145499

Zinc Gluconate 1 Publications Verification	PPAR NF-κB Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Zinc Gluconate is a zinc supplement in the form of a gluconate salt, which plays a role in various physiological processes such as immune function, wound healing, and olfaction. Zinc Gluconate has a *LD₅₀* of 39.6 mg/kg in mice (Tail vein injection). Zinc Gluconate can be used in the research of inflammation, zinc deficiency, colds, cancer, and nutritional supplements .

HY-D1005A6

Poloxamer 124 (L44) PEG-PPG-PEG, 2200 (Average)	Environmental Pollutants Biochemical Assay Reagents	Others
Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD₅₀ of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].

HY-W088065

Sodium formate	Environmental Pollutants DNA/RNA Synthesis	Others
Sodium formate acts as a key promoter for heterogeneous nucleation of ZIF crystals and thin film synthesis. It is also recognized as a GRAS substance by the FDA, and serves as a cosmetic preservative and food additive. Sodium formate has low acute oral toxicity (acute oral *LD₅₀*=7410 mg/kg and acute intravenous *LD₅₀*=807 mg/kg in mice), with no heritable or carcinogenic effects, but exhibits embryonic developmental toxicity and teratogenicity at high concentrations. Sodium formate may cause moderate irritation to rabbit eyes, is relatively safe to the skin, and does not induce tumor formation in rats in vivo. Sodium formate is rapidly absorbed and oxidized to carbon dioxide in vivo, and forms DNA adducts in specific metabolic deficiency models or upon high-dose exposure .

HY-D1163

Chromium(III) acetate 2 Publications Verification Chromium acetate; Chromic acetate; Chromium triacetate	Environmental Pollutants AMPK	Metabolic Disease
Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an *LD₅₀* of 2365 mg/kg in rats .

HY-B0824

Bifenthrin 1 Publications Verification	Environmental Pollutants Sodium Channel	Neurological Disease
Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD₅₀=0.15 ng/mg) and C. quinquefasciatus (LD₅₀=0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material .

HY-16172

DMAPT 2 Publications Verification Dimethylamino Parthenolide	NF-κB	Cancer
DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .

HY-B1169

Timonacic 1 Publications Verification 1,3-Thiazolidine-4-carboxylic acid	Amino Acid Derivatives	Cardiovascular Disease Cancer
Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a *LD₅₀* of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer .

HY-N6715

Tenuazonic acid	Influenza Virus Bacterial Enterovirus Photosystem II	Infection Cancer
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-152927

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)	Biochemical Assay Reagents	Others
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD₅₀ >2.5 g/kg .

HY-W131444

Insecticidal agent 15	Insecticide	Others
Insecticidal agent 15 (compound 8f) is a potent insecticidal agent that shows *LD₅₀* of 4.27 nmol/mg for adult female Ae. Aegypti .

HY-N2542

Tubeimoside III 2 Publications Verification	Interleukin Related NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an *LD₅₀* of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .

HY-78086

m-Tolualdehyde 3-MethylbenzaLDehyde	Endogenous Metabolite Bacterial	Infection
m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a *LD₅₀* of 1.97 μg/cm ³ .

HY-N4202

Dihydrorotenone	Environmental Pollutants Insecticide Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology Cancer
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD₅₀ of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies .

HY-W099757

(±)-Coniine hydrochloride 2-Propylpiperidine hydrochloride	nAChR	Neurological Disease
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an *EC₅₀* value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD₅₀ value of 7.7 mg/kg .

HY-114806

Fenclofenac Flenac; R 67408	Thyroid Hormone Receptor	Inflammation/Immunology
Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral *LD₅₀* of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research .

HY-107532

N-Nonyldeoxynojirimycin NN-DNJ; Nonyl-DNJ	Glycosidase Flavivirus Parasite	Infection Metabolic Disease Cancer
N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC₅₀: 0.42 μM) and α-1,6-glucosidase (IC₅₀: 8.4 μM). N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breakdown, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an *LD₅₀* of 5 mM for adults of Bemisia tabaci .

HY-16172A

(S)-DMAPT (S)-Dimethylamino Parthenolide	NF-κB	Cancer
(S)-DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect .

HY-162650

SL44	ClpP	Cancer
SL44 is an agonist for human caseinolytic protease P (HsClpP), with an *EC₅₀* of 1.30 μM. SL44 inhibits the proliferation of LM3 with an *IC₅₀* of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD₅₀=400 mg/kg). SL44 exhibits good pharmacokinetic characters in rat models .

HY-W653921

Tenuazonic acid-d13	Isotope-Labeled Compounds Enterovirus Photosystem II Influenza Virus Bacterial	Infection Cancer
Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-135286A

(+)-Neomenthol	Parasite	Infection
(+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with *LD₅₀* values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively .

HY-128430

Farnesyl acetate	Parasite DNA/RNA Synthesis	Infection
Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD₅₀ of 7867 ppm .

HY-121229A

(±)-Coniine 2-Propylpiperidine	nAChR	Others
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .

HY-B1869

Metsulfuron-methyl 2 Publications Verification	Environmental Pollutants Herbicide	Others
Metsulfuron-methyl is a systemic sulfonylurea herbicide that has been widely used to control broadleaf weeds and annual grasses in rice, corn, wheat, and barley. Metsulfuron-methyl exhibits high herbicidal activity and low mammalian toxicity, with an **LD₅₀ for rats exceeding 5000 mg/kg .**

HY-Y1275S

N-Methylpyrrolidone-d9 NMP-d₉; 1-Methyl-2-pyrrolidinone-d₉	Isotope-Labeled Compounds Biochemical Assay Reagents	Cancer
N-Methylpyrrolidone-d₉ (NMP-d₉) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a *LD₅₀* value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-N10695

Celangulatin C	Parasite	Infection
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows *LD₅₀* against Mythimna separata of 280.4 μg/mL .

HY-110073

iMAC2 hydrochloride	Apoptosis	Inflammation/Immunology Cancer
iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an *IC₅₀* of 28 nM and a *LD₅₀* of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release .

HY-127165

Velnacrine HP 029 free base; Hydroxytacrine	Cholinesterase (ChE)	Neurological Disease
Velnacrine (HP 029 free base) is an inhibitor for acetylcholinesterase (AChE), with an *IC₅₀* of 3.27 μM. Velnacrine reverses the Scopolamine (HY-N0296)-induced amnesia in rat models, and exhibits acute toxicity with LD₅₀ of 65 mg/kg .

HY-173053

HDAC-IN-87	HDAC Fungal	Infection
HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD₅₀ of greater than 500 mg/kg in male and female rats .

HY-125721

Tetranactin	Fungal Bacterial Antibiotic	Infection
Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin *LD₅₀* for intraperitoneal injection in mice is greater than 300 mg/kg, and the *LD₅₀* is greater than 15,000 mg/kg .

HY-B1169R

Timonacic (Standard) 1,3-Thiazolidine-4-carboxylic acid (Standard)	Amino Acid Derivatives Reference Standards	Cardiovascular Disease Cancer
Timonacic (Standard) is the analytical standard of Timonacic. This product is intended for research and analytical applications. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a LD50 of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer .

HY-N6715R

Tenuazonic acid (Standard)	Reference Standards Influenza Virus Bacterial Enterovirus Photosystem II	Infection Cancer
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-129208

Viridicatumtoxin	Antibiotic Fungal	Infection
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a *LD₅₀* of 122.4 mg/kg in rats.

HY-103272

iMAC2	Apoptosis	Inflammation/Immunology Cancer
iMAC2 is a potent MAC inhibitor with an *IC₅₀* of 28 nM and an *LD₅₀* of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Fungal	Infection
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-N10697

Angulatin G Celangulatin E	Parasite	Infection
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows *LD₅₀* against Mythimna separata of 1656.4 μg/mL .

HY-177099

Lorotomidate	GABA Receptor	Neurological Disease
Lorotomidate (Example 16) is a GABAA receptor agonist. Lorotomidate has anaesthetic effects (ED₅₀: i.v., 2 mg/kg in KM mice; *LD₅₀*: 46.5 mg/kg in KM mice). Lorotomidate has no inhibitory effect on the secretion of corticosteroids in animals, and thus has good safety .

HY-W663230

Eugenitin	Parasite	Infection
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with *LD₅₀*=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-W024485

SARS-CoV-2-IN-86	SARS-CoV Drug Derivative	Infection
SARS-CoV-2-IN-86 (Compound 2734589) is SARS-CoV-2 methyltransferases nsp14 and nsp16 inhibitor, Andrographolide (HY-N0191) derivative. SARS-CoV-2-IN-86 has low toxicity, and according to toxicity analysis, the predicted LD50 is 700 mg/kg .

HY-N9495

(-)-trans-Myrtanol	Bacterial	Infection
(-)-trans-Myrtanol is an antimicrobial and acaricide agent. (-)-trans-Myrtanol exhibits potent antimicrobial activities against harmful intestinal bacteria. (-)-trans-Myrtanol shows acaricidal activities for D. farinae, D. pteronyssinus, T. putrescentiae with *LD₅₀* values of 2.30 µg/cm ², 2.22 µg/cm ², 12.95 µg/cm ², respectively .

HY-129278

Lunarine	Parasite	Infection Cardiovascular Disease Neurological Disease
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD₅₀ of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with K_i of 304 μM .

HY-161618

MJ04	JAK EGFR PI3K IGF-1R GSK-3	Inflammation/Immunology Endocrinology
MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an *IC₅₀* of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD₅₀ >2 g/kg) .

HY-W711035

Picolinafen AC 900001	p38 MAPK PI3K Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Cytochrome P450	Inflammation/Immunology
Picolinafen is a pyridine-class herbicide that acts as a phytoene desaturase (PDS) inhibitor. Picolinafen effectively controls broadleaf weeds and disrupts carotenoid biosynthesis. Picolinafen exhibits cytotoxicity to porcine trophectoderm (pTr) and luminal epithelial (pLE) cells. Picolinafen induces (ROS accumulation, calcium depletion, and activates (MAPK and PI3K signaling pathways, leading to decreased cell viability, increased apoptosis, impaired migration, and altered expression of implantation-related genes. Picolinafen has an *LD₅₀* value of 2.7 mg/kg in mammals and 7 μg/L in fish. Picolinafen exhibits toxic effects during zebrafish embryogenesis ^[1][2].

HY-159897

PAK4-IN-5	PAK LIM Kinase (LIMK) Apoptosis Reactive Oxygen Species (ROS)	Cancer
PAK4-IN-5 (Compound 12i) is a PAK4 inhibitor (IC₅₀: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD₅₀: >500 mg/kg for mice (p.o.) .

HY-N6715S

Tenuazonic acid-13C10	Influenza Virus Bacterial Isotope-Labeled Compounds	Infection
Tenuazonic acid- ¹³C₁₀ is ¹³C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-W103488

Chloridazon	Environmental Pollutants Herbicide	Others
Chloridazon is a herbicide with an *LD₅₀* value of 76.6 ppm at genotoxicity assay .

HY-129733

LND 623	Na+/K+ ATPase	Cardiovascular Disease
LND 623 is an inotropic aminosteroid with positive inotropic properties. LND 623 inhibits Na ⁺/K ⁺ ATPase activity. The *LD₅₀* of LND 623 infused i.v. is around 45 mg/kg, a value ten times higher than the *LD₅₀* for Ouabain (HY-B1457) .

HY-126715

Pimelautide RP 44102	HIV Virus Protease	Inflammation/Immunology
Pimelautide (RP 44102), a desmuramyl peptidolipid, is an adjuvant. Pimelautide shows a LD₅₀ of 410 mg/kg (i.v, mouse) .

HY-114614

Clenpirin	Parasite	Infection
Clenpirin is a insecticide against cattle ticks Boophilus microplus. Clenpirin exhibits slightly toxicity to rats with LD₅₀ of 3050 mg/kg .

HY-157162

Insecticidal agent 5	Cholinesterase (ChE)	Others
Insecticidal agent 5 (compound 8) is an AChE-targeting insecticide with an LD50 of 27.65 ppm against the cotton leafworm Spodoptera littoralis .

Cat. No.	Product Name	Type

HY-Y1275

N-Methylpyrrolidone NMP; 1-Methyl-2-pyrrolidinone	Biochemical Assay Reagents
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a *LD₅₀* value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-D1005A6

Poloxamer 124 (L44)

PEG-PPG-PEG, 2200 (Average)

Biochemical Assay Reagents

Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD₅₀ of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].

HY-W088065

Sodium formate

Biochemical Assay Reagents

Sodium formate acts as a key promoter for heterogeneous nucleation of ZIF crystals and thin film synthesis. It is also recognized as a GRAS substance by the FDA, and serves as a cosmetic preservative and food additive. Sodium formate has low acute oral toxicity (acute oral LD₅₀=7410 mg/kg and acute intravenous LD₅₀=807 mg/kg in mice), with no heritable or carcinogenic effects, but exhibits embryonic developmental toxicity and teratogenicity at high concentrations. Sodium formate may cause moderate irritation to rabbit eyes, is relatively safe to the skin, and does not induce tumor formation in rats in vivo. Sodium formate is rapidly absorbed and oxidized to carbon dioxide in vivo, and forms DNA adducts in specific metabolic deficiency models or upon high-dose exposure .

HY-Y0850U3

PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization)

Polyvinyl alcohol (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization); Poly(Ethenol) (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization)

Biochemical Assay Reagents

PVA (Polyvinyl alcohol) (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) is a water-soluble, biodegradable, biocompatible and non-immunogenic polymer. PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) causes no irritation to rabbit eyes, no skin sensitization in guinea pigs, promotes the proliferation of human skin keratinocytes, and reduces the loss of corneal endothelial cells. The LD₅₀ of PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) in rats and dogs is greater than 10 g/kg. PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) is hardly absorbed by the digestive system, causes no adverse effects upon long-term oral administration, and shows no mutagenicity or carcinogenicity. However, repeated intravenous or portal vein injection of PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) may induce pathological changes such as glomerular lesions, anemia, hypertension or liver fibrosis in rats or dogs. Crosslinked nanofibers prepared by modifying PVA (Mw 125000, 98-99% hydrolyzed, ~2800 polymerization) can be used in studies related to wound dressings and other applications .

HY-W276164

Sodium octadecyl sulfate

Sodium stearyl sulfate

Biochemical Assay Reagents

Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD₅₀ greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems .

Cat. No.	Product Name	Target	Research Area

HY-W024485

SARS-CoV-2-IN-86	SARS-CoV Drug Derivative	Infection
SARS-CoV-2-IN-86 (Compound 2734589) is SARS-CoV-2 methyltransferases nsp14 and nsp16 inhibitor, Andrographolide (HY-N0191) derivative. SARS-CoV-2-IN-86 has low toxicity, and according to toxicity analysis, the predicted LD50 is 700 mg/kg .

HY-P2047

Lavendomycin Antibiotic FR-900201	Antibiotic Bacterial	Infection
Lavendomycin is a peptide antibiotic from Streptomyces. Lavendomycin inhibits Gram-positive bacteria .

HY-P11615

FuK	Bacterial	Infection
FuK is a WK₂-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an *LD₅₀* of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6715

Tenuazonic acid	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-N2542

Tubeimoside III 2 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related NO Synthase
Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an *LD₅₀* of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .

HY-78086

m-Tolualdehyde 3-MethylbenzaLDehyde	Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Other Diseases Plants Disease Research Fields Vachellia nilotica (L.) P. J. H. Hurter & Mabb. Source Classification	Endogenous Metabolite Bacterial
m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a *LD₅₀* of 1.97 μg/cm ³ .

HY-N0440

Germacrone 2 Publications Verification	Infection Classification of Application Fields Terpenoids Sesquiterpenes Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae	Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 inﬂuenza A virus and the inﬂuenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .

HY-N4202

Dihydrorotenone	Structural Classification Erycibe ferruginea C. Y. Wu Flavonoids Neurological Disease Classification of Application Fields Isoflavanones Plants Convolvulaceae Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Environmental Pollutants Insecticide Apoptosis p38 MAPK
Dihydrorotenone is an insecticide and irreversible inhibitor of mitochondrial complex I. Dihydrorotenone may induce Parkinson's disease. Dihydrorotenone induces apoptosis in human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. The oral LD₅₀ of dihydrorotenone in rats is approximately 2.5 g/kg. Dihydrorotenone exhibits insecticide activity and cytotoxicity to plasma cells. Dihydrorotenone can be used to establish animal models of Parkinson's disease, safety assessment of natural pesticides, and potential cancer chemoprevention studies .

HY-N1050

Zederone	Terpenoids Sesquiterpenes Plants Curcuma elata Roxb. Source Classification Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK) Bacterial
Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with *IC₅₀s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD₅₀* value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis .

HY-W099757

(±)-Coniine hydrochloride 2-Propylpiperidine hydrochloride	Alkaloids Ligularia veitchiana (Hemsl.) Greenm. Pyridine Alkaloids Plants Umbelliferae Source Classification	nAChR
(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an *EC₅₀* value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD₅₀ value of 7.7 mg/kg .

HY-N4031

Humantenine	Alkaloids Structural Classification Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Source Classification	Anaplastic lymphoma kinase (ALK) METTL3
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection *LD₅₀* values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-135286A

(+)-Neomenthol	Natural Products Acacia farnesiana (Linn.) Willd. Labiatae Plants Source Classification	Parasite
(+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with *LD₅₀* values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively .

HY-128430

Farnesyl acetate	Infection other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Disease Research Fields Source Classification	Parasite DNA/RNA Synthesis
Farnesyl acetate is a sesquiterpene isolated from the leaves of Amomum gagnepainii. Farnesyl acetate has significant toxicity against red palm weevil larvae with a LD₅₀ of 7867 ppm .

HY-121229A

(±)-Coniine 2-Propylpiperidine	Alkaloids Piperidine Alkaloids Tsuga chinensis (Franch.) Pritz. Classification of Application Fields Pinaceae Other Diseases Plants Disease Research Fields Source Classification	nAChR
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .

HY-N10695

Celangulatin C	Pinaceae Terpenoids Sesquiterpenes Pseudolarix amabilis (J. Nelson) Rehder Plants Source Classification	Parasite
Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows *LD₅₀* against Mythimna separata of 280.4 μg/mL .

HY-125721

Tetranactin	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Fungal Bacterial Antibiotic
Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin *LD₅₀* for intraperitoneal injection in mice is greater than 300 mg/kg, and the *LD₅₀* is greater than 15,000 mg/kg .

HY-N6715R

Tenuazonic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Influenza Virus Bacterial Enterovirus Photosystem II
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-129208

Viridicatumtoxin	Other Terpenoids Infection Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Source Classification	Antibiotic Fungal
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a *LD₅₀* of 122.4 mg/kg in rats.

HY-138100

Hyalodendrin (+)-Hyalodendrin	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-N10697

Angulatin G Celangulatin E	Terpenoids Sesquiterpenes Celastraceae Celastrus angulatus Maxim. Plants Source Classification	Parasite
Angulatin G (Celangulatin E) is an insecticidal sesquiterpene polyol ester with a β-dihydroagarofuran sesquiterpene skeleton, which can be isolated from the root bark of Celastrus angulatus. Angulatin G shows *LD₅₀* against Mythimna separata of 1656.4 μg/mL .

HY-W663230

Eugenitin	Natural Products Microorganisms Source Classification	Parasite
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with *LD₅₀*=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-N9495

(-)-trans-Myrtanol	Structural Classification Other Monoterpenes Terpenoids Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Source Classification	Bacterial
(-)-trans-Myrtanol is an antimicrobial and acaricide agent. (-)-trans-Myrtanol exhibits potent antimicrobial activities against harmful intestinal bacteria. (-)-trans-Myrtanol shows acaricidal activities for D. farinae, D. pteronyssinus, T. putrescentiae with *LD₅₀* values of 2.30 µg/cm ², 2.22 µg/cm ², 12.95 µg/cm ², respectively .

HY-129278

Lunarine	Alkaloids Lunaria annua L. Other Alkaloids Plants Brassicaceae Source Classification	Parasite
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD₅₀ of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with K_i of 304 μM .

HY-N0531

Filixic acid ABA	Infection Quinones Urticaceae Classification of Application Fields Debregeasia wallichiana (Wedd.) Wedd. Phenols Polyphenols Benzene Quinones Plants Disease Research Fields Source Classification	Parasite
Filixic acid ABA is a molluscicidal agent against B. peregrina adult snails, with an *LD₅₀* of 8.40 ppm. Filixic acid ABA shows 100% mortality of B. peregrina at 15 ppm .

HY-126645

Atelopidtoxin	Natural Products Animals Animal Venoms Source Classification	Sodium Channel
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-121182

Chalcomycin	Microorganisms Macrolide Antibiotics Antibiotics Source Classification	Antibiotic Bacterial
Chalcomycin is a macrolide antibiotic, which exhibits antimicrobial activities against gram-positive Staphylococcus aureus and Streptococcus pyogenes. Chalcomycin protects mice from infection with a variety of staphylococci and streptococc, without significant toxicity (LD₅₀ >2500 mg/kg) .

HY-N15404

Glaucarubin	Natural Products Simaroubaceae Simarouba glauca DC. Plants Source Classification	Parasite
Glaucarubin is a bitter lactone found in Simaruba glauca. Glaucarubin can be used as an amœbicide for amebiasis research. Glaucarubin is well tolerated, with LD₅₀s of 1,600 mg/kg for mice and 6,400 mg/kg for rats .

HY-135286AR

(+)-Neomenthol (Standard)	Structural Classification Natural Products Acacia farnesiana (Linn.) Willd. Labiatae Plants Source Classification	Reference Standards Parasite
(+)-Neomenthol (Standard) is the analytical standard of (+)-Neomenthol. This product is intended for research and analytical applications. (+)-Neomenthol is a potent miticide. (+)-Neomenthol shows acaricidal activitie with LD50 values of 0.32, 0.256 µg/mL for Dermatophagoides farinae and Dermatophagoides pteronyssinus, respectively[1].

HY-116498

Penigequinolone A	Microorganisms Source Classification	Others
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.

HY-N14195

Mathemycin A	Natural Products Microorganisms Source Classification	Fungal
Mathemycin A has an inhibitory effect on pathogenic fungi. Mathemycin A inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL), and it inhibits JO8 in greenhouse (LD₅₀ is 42 X 10 ^-6, LC₉₀ is 500 X 10 ^-6) .

HY-N15473

Isopaucifloral F (±)-Isopaucifloral F	Phenols Polyphenols Plants Dipterocarpaceae Vatica pauciflora (Korth.) Blume Source Classification	Estrogen Receptor/ERR Drug Derivative
Isopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC₅₀: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD₅₀ in rats: > 5 mg/kg .

HY-121104

Bactobolin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Bactobolin (Compound 1) is an antibiotic, which inhibits Escherichia coli, Salmonella, Shigella, Staphylococcus and Bacillus subtilis, with MICs of 0.3-6.25 μg/mL. Bactobolin exhibits antitumor efficacy against leukemia, with a *LD₅₀* value of 6.25-12.5 mg/kg .

HY-137139

10'-Desmethoxystreptonigrin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial Farnesyl Transferase
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an *IC₅₀* of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD₅₀ is 8.8 mg/kg) .

HY-N16426

Mycoleptone A	Natural Products Microorganisms Source Classification	Parasite
Mycoleptone A is an azafluorenone compound. Mycoleptone A exhibits certain anti-leishmanial activity, with an *LD₅₀* of 28.5 μM against L. major. Mycoleptone A shows cytotoxicity against human prostate cancer cell line PC3, with an *IC₅₀* of 10.0 μM. Mycoleptone A can be used in research on anti-parasitic and anti-tumor aspects .

HY-N2542R

Tubeimoside III (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Source Classification	Reference Standards Interleukin Related NO Synthase
Tubeimoside III (Standard) is the analytical standard of Tubeimoside III (HY-N2542). This product is intended for research and analytical applications. Tubeimoside III is a triterpenoid saponin. Tubeimoside III has anti-inflammatory and antitumor effects. Tubeimoside III has an *LD₅₀* of 15 mg/kg by intraperitoneal injection in ICR mice. Tubeimoside III can be used for the research of tumors and inflammatory diseases .

HY-78086R

m-Tolualdehyde (Standard) 3-MethylbenzaLDehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Labiatae Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb. Source Classification	Reference Standards Endogenous Metabolite Bacterial
m-Tolualdehyde (Standard) is the analytical standard of m-Tolualdehyde. This product is intended for research and analytical applications. m-Tolualdehyde (3-Methylbenzaldehyde) is a natural product. m-Tolualdehyde can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a *LD₅₀* of 1.97 μg/cm ³ .

HY-130596

DC-86-M	Microorganisms Antibiotics Disease Research Anticancer Source Classification	Antibiotic Bacterial
DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD₅₀ of 25 mg/kg .

HY-N15424

Himachalol	Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Plants Source Classification	Apoptosis Bcl-2 Family
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD₅₀ of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) .

HY-N16646

Micrometam A	Structural Classification Rutaceae Phenols Polyphenols Micromelum falcatum (Lour.) Tanaka Plants Source Classification	Drug Derivative
Micrometam A is a phenethylamine derivative found in Micromelum falcatum. Micrometam A exhibits anti-halogenation activity with a *LD₅₀* of 18.5 μg/mL .

HY-N11731

Rotenonone	Structural Classification Leguminosae Ketones, Aldehydes, Acids Plants Tephrosia candida DC. Source Classification	Insecticide Drug Derivative
Rotenonone is a derivative of Rotenone (HY-B1756), with a *LD₅₀* of 0.68 μg/g against larvae of Spodoptera litura .

HY-N11730

6',7'-Epoxyrotenone	Structural Classification Natural Products Leguminosae Ketones, Aldehydes, Acids Derris trifoliata Lour. Plants Source Classification	Drug Derivative
6',7'-Epoxyrotenone is a derivative and photodegradation product of Rotenone (HY-B1756), with an acute intraperitoneal *LD₅₀* of 7.2 mg/kg in mice .

HY-N11732

O-Demethylrotenone	Structural Classification Natural Products Leguminosae Ketones, Aldehydes, Acids Derris trifoliata Lour. Plants Source Classification	Drug Derivative
O-Demethylrotenone is a rotenone (HY-B1756) derivative and a photodegradation product of rotenone that induces acute intraperitoneal toxicity. The acute intraperitoneal *LD₅₀* of O-Demethylrotenone in Mus musculus is 8.0 mg/kg .

HY-N18254

Hokbusine A	Structural Classification Alkaloids Other Alkaloids Ranunculaceae Aconitum jaluense Kom. Plants Source Classification	Drug Derivative
Hokbusine A is a diterpenic alkaloid and C₁₉ norditerpenoid (aconitine-type) alkaloid that can be found in the roots of Aconitum napellus L. (Swiss variety) and Aconitum jaluense .Hokbusine A exhibits low acute toxicity in ddY mice via intraperitoneal administration, with an *LD₅₀* value greater than 1 mg/kg .

Cat. No.	Product Name	Chemical Structure

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-Y1275S

N-Methylpyrrolidone-d9

N-Methylpyrrolidone-d₉ (NMP-d₉) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-N6715S

Tenuazonic acid-13C10

Tenuazonic acid- ¹³C₁₀ is ¹³C labeled Tenuazonic acid (HY-N6715). Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD50 is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-175991S

Sodium octadecyl sulfate-d37

Sodium octadecyl sulfate-d₃₇ (Sodium stearyl sulfate-d₃₇) is the deuterium labeled Sodium octadecyl sulfate (HY-W276164). Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD₅₀ greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems .

Cat. No.	Product Name		Classification

HY-151829

Fmoc-L-Asn(EDA-N3)-OH		Azide
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-152927

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)		Release-retarding Agents
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD₅₀ >2.5 g/kg .

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