Cat. No.: HY-W145499

Zinc Gluconate

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Zinc Gluconate is a zinc supplement in the form of a gluconate salt, which plays a role in various physiological processes such as immune function, wound healing, and olfaction. Zinc Gluconate has a LD₅₀ of 39.6 mg/kg in mice (Tail vein injection). Zinc Gluconate can be used in the research of inflammation, zinc deficiency, colds, cancer, and nutritional supplements.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 4468-02-4
Formula: C₁₂H₂₂O₁₄Zn
Molecular Weight:455.67

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Zinc Gluconate Chemical Structure

CAS No.: 4468-02-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PPAR Isoforms :

All NF-κB Isoforms :

All Toll-like Receptor (TLR) Isoforms :

In Vitro

Zinc Gluconate (1 μg/mL; 24 h) can increase the mRNA expression of PPAR-α in the skin explants stimulated by LPS (HY-D1056)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

LPS (HY-D1056) treated skin explants
Concentration:

1 μg/mL
Incubation Time:

24 h
Result:

Increased the mRNA level of PPAR-α.

In Vivo

Zinc Gluconate (5.13-30.78 mg/kg; tail vein injection; 3 days) has a protective effect in the model of intestinal mucosal barrier injury in mice induced by antibiotics and LPS (HY-D1056)^[2].
Zinc Gluconate (33 mM; nasal irrigation; single dose) can lead to the impairment of olfactory function in female CD1 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Antibiotics and LPS (HY-D1056) treated male C57BL/6J mice aged 6-8 weeks old (20±2g)^[2]
Dosage:

5.13, 10.26 and 30.78 mg/kg
Administration:

Tail vein injection; 3 days
Result:

Restored body weight, alleviated diarrheal symptoms and pathological damage, and maintained the structural integrity of intestinal epithelial cells (IECs) in mice.
Reduced intestinal mucosal permeability by upregulating TJassociated proteins (ZO-1, Occludin, Claudin-1, and JAM-A) and downregulating MLCK, thereby repairing intestinal mucosal barrier damage induced by dual induction of antibiotics and LPS.
Suppressed the TLR4/NF-κB signaling pathway, demonstrating anti-inflammatory properties and preserving barrier integrity.
Restored gut microbiota diversity and richness.
Modulated the relative abundance of beneficial human gut bacteria and harmful bacteria.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 4468-02-4
Appearance Solid
Molecular Weight 455.67
Formula C₁₂H₂₂O₁₄Zn
Color White to off-white
SMILES

O[C@@H]([C@@H]([C@@H](CO)O)O)[C@@](C([O-]1)=O)([H])[OH][Zn+2]1([O-]C2=O)[OH][C@]2([H])[C@@H](O)[C@H](O)[C@H](O)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Biomed Pharmacother

Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. [Abstract]

2024 Jul 16:177:117129. PMID: 39018874

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (109.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (109.73 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1946 mL

10.9729 mL

21.9457 mL

5 mM

0.4389 mL

2.1946 mL

4.3891 mL

10 mM

0.2195 mL

1.0973 mL

2.1946 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Poiraud C, et al. Zinc gluconate is an agonist of peroxisome proliferator-activated receptor-α in the epidermis. Exp Dermatol. 2012 May;21(5):347-51. [Content Brief]

[2]. Wang Y, et al. Protective effect of zinc gluconate on intestinal mucosal barrier injury in antibiotics and LPS-induced mice. Front Microbiol. 2024 May 23;15:1407091. [Content Brief]

[3]. Duncan-Lewis CA, et al. Effects of zinc gluconate and 2 other divalent cationic compounds on olfactory function in mice. Comp Med. 2011 Aug;61(4):361-5. [Content Brief]

[4]. Hao, Yahui, et al. Zinc gluconate and its side-effects in clinical use.

[5]. Wang YC, et al. Determination of the median lethal dose of zinc gluconate in mice and safety evaluation. BMC Pharmacol Toxicol. 2024 Feb 5;25(1):15. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.1946 mL	10.9729 mL	21.9457 mL	54.8643 mL
	5 mM	0.4389 mL	2.1946 mL	4.3891 mL	10.9729 mL
	10 mM	0.2195 mL	1.0973 mL	2.1946 mL	5.4864 mL
	15 mM	0.1463 mL	0.7315 mL	1.4630 mL	3.6576 mL
	20 mM	0.1097 mL	0.5486 mL	1.0973 mL	2.7432 mL
	25 mM	0.0878 mL	0.4389 mL	0.8778 mL	2.1946 mL
	30 mM	0.0732 mL	0.3658 mL	0.7315 mL	1.8288 mL
	40 mM	0.0549 mL	0.2743 mL	0.5486 mL	1.3716 mL
	50 mM	0.0439 mL	0.2195 mL	0.4389 mL	1.0973 mL
	60 mM	0.0366 mL	0.1829 mL	0.3658 mL	0.9144 mL
	80 mM	0.0274 mL	0.1372 mL	0.2743 mL	0.6858 mL
	100 mM	0.0219 mL	0.1097 mL	0.2195 mL	0.5486 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Zinc Gluconate

1 Cited Publications

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Zinc Gluconate

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Publications Citing Use of MedChemExpress (MCE) Zinc Gluconate

All PPAR Isoforms

All NF-κB Isoforms

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Zinc Gluconate Related Classifications

HY-W145499 Related Classifications