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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
LDL oxidation
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "LDL oxidation" in MCE Product Catalog:
8
8 Publications Verification
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Domaines de recherche:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
2
2 Cited Publications
Target:
Domaines de recherche:
N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation .
1
Category:
Microorganisms Monophenols Metabolic Disease Phenols Plants Other Families Extract Endogenous metabolite Disease Research Fields
Target:
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Target:
1
Category:
Flavonols Flavonoids Pedaliaceae Extract Plants Uncarina grandidieri (Baill.) Ihlenf. & Straka
Target:
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Category:
Convolvulaceae Extract Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Ipomoea batatas (Linn.) Lamarck
Target:
Synonyms: L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH
Cat. No.: HY-N0859
CAS No.: 69363-14-0
Synonyms: Schizanhenol; Gomisin-K3
Category:
Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Extract Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer
Target:
Cat. No.: HY-P5763
CAS No.: 1415039-77-8
Synonyms: PNX-20
Target:
Toll-like Receptor (TLR) MyD88 NF-κB Sirtuin NOD-like Receptor (NLR) ASCT Caspase Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) STAT
Domaines de recherche:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Phoenixin-20 (PNX-20) is a neuropeptide that activates GPR173. Phoenixin-20 inhibits LPS-induced TLR-4/MyD88/NF-κB signaling, pro-inflammatory cytokines, adhesion molecules, MMPs, and cytotoxicity. Phoenixin-20 increases SIRT1 and inhibits NLRP3/ASC/caspase-1, oxidative stress, and IL-1β/IL-18. Phoenixin-20 alleviates ox-LDL-induced endothelial dysfunction, monocyte adhesion, adhesion molecules, cytokines, NADPH oxidase/NOX-4, and ROS. Phoenixin-20 promotes GPR173/STAT6-mediated anti-inflammatory polarization of microglia and neuroprotection. Phoenixin-20 can be used in research on dental pulp infection, pulmonary arterial hypertension, atherosclerosis, neuroinflammation, anxiety, and neurodegenerative diseases .
Target:
Domaines de recherche:
LDL-IN-2 (compound 3) is an antioxidant against copper mediated low-density lipoproteins (LDL) oxidation .
Cat. No.: HY-N3596
CAS No.: 84575-10-0
Synonyms: Aquillochin
Target:
Cat. No.: HY-N10638
CAS No.: 916888-49-8
Target:
Domaines de recherche:
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .
Synonyms: L-Cysteinylglycine TFA; Cys-Gly TFA; H-Cys-Gly-OH TFA
Cat. No.: HY-W791754
CAS No.: 827610-11-7
Target:
Domaines de recherche:
Paeonolsilate (sodium) can inhibit ox-LDL-induced macrophage foam cell formation and inflammation in atherosclerosis. Paeonolsilate (sodium) inhibits NF-κB activation and oxidative stress response induced by ox-LDL. Paeonolsilate (sodium) can be studied in anti-atherosclerosis research .
Cat. No.: HY-N15706
CAS No.: 76939-42-9
Target:
Cat. No.: HY-113110R
CAS No.: 19246-18-5
Synonyms: L-Cysteinylglycine (Standard); Cys-Gly (Standard); H-Cys-Gly-OH (Standard)
Cat. No.: HY-119265
CAS No.: 615264-62-5
Target:
Domaines de recherche:
LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC50 of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity .
Target:
Domaines de recherche:
LDL-IN-1 (Compound 1) is an antioxidant, and is active against copper mediated LDL oxidation (IC50 = 52 μM). LDL-IN-1 is also an Acyl-CoA:cholesterol acyltransferase-1 and -2 (ACAT-1/2) inhibitor, with IC50s of 60 μM. LDL-IN-1 can be used for anti-atherosclerotic research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
