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LFA-1/ICAM-1 interaction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Drug Intermediate (1) Integrin (8) Interleukin Related (1) Reference Standards (1)
By Research Areas:	Cancer (1) Endocrinology (1) Inflammation/Immunology (9) Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110117

BIRT 377 4 Publications Verification	Integrin Interleukin Related	Inflammation/Immunology
BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders .

HY-107587

A-286982 3 Publications Verification	Integrin	Inflammation/Immunology
A-286982 is a potent and allosteric **LFA-1/ICAM-1 interaction inhibitor with IC₅₀*s of 44 nM and 35 nM in an LFA-1/ICAM-1* binding and LFA-1-mediated cellular adhesion assay, respectively .

HY-110086

RWJ 50271	Integrin	Inflammation/Immunology
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC₅₀ of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion .

HY-10596

BMS-688521 1 Publications Verification	Integrin	Inflammation/Immunology
BMS-688521 is a highly potent, orally active inhibitor of the *LFA-1/ICAM* interaction, with an IC₅₀ of 2.5 nM in the adhesion assay and an IC₅₀ of 60 nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosinophilic lung inflammation model .

HY-122192

ICAM-1988	Integrin	Inflammation/Immunology
ICAM-1988 is a small molecule lymphocyte function-associated antigen-1 (LFA-1) antagonist that disrupts the LFA-1/ICAM-1 interaction and has anti-inflammatory activity .

HY-P992413

MOR102	Integrin	Inflammation/Immunology
MOR102 is a fully human IgG4 monoclonal antibody and an *ICAM-1* inhibitor, lacking cross-reactivity with ICAM-2 and ICAM-3. MOR102 binds to the *LFA-1* binding site within *ICAM-1* domain 1, blocks *ICAM-1/LFA-1* interaction, binds human keratinocytes with increased binding to interferon-γ-stimulated keratinocytes. MOR102 inhibits lymphocyte adhesion, reduces lymphocyte proliferation, prevents local T-cell activation, reduces inflammatory infiltrate, restores orthokeratotic differentiation, and reduces epidermal thickness. MOR102 can be used for the research of psoriasis .

HY-P992053

Anti-CD11a Antibody (MHM24)	Integrin	Inflammation/Immunology
Anti-CD11a Antibody (MHM24) is a monoclonal antibody targeting murine CD11a. Anti-CD11a Antibody (MHM24) binds to high-affinity (open) and low-affinity (closed) conformations of the α_L subunit of *LFA-1, and functionally blocks LFA-1-mediated* interactions. Anti-CD11a Antibody (MHM24) blocks *ICAM-1* binding to LFA-1-expressing cells. Anti-CD11a Antibody (MHM24) inhibits adhesion of high-affinity LFA-1-expressing cells to keratinocytes. Anti-CD11a Antibody (MHM24) inhibits PHA-induced lymphocyte proliferation. Anti-CD11a Antibody (MHM24) can be used for the research of inflammatory and autoimmune diseases. Recommend Isotype Controls: mouse IgG1 kappa, Isotype Control (HY-P99977) .

HY-W241255

2-Aminoindan-2-carboxylic acid	Amino Acid Derivatives Drug Intermediate	Neurological Disease Inflammation/Immunology Endocrinology Cancer
2-Aminoindan-2-carboxylic acid is a conformationally restricted Phenylalanine analog and molecular building block. 2-Aminoindan-2-carboxylic acid constitutes a component of allosteric LFA-1 antagonists targeting the *LFA-1/ICAM-1* interaction. 2-Aminoindan-2-carboxylic acid serves as a molecular building block for various biologically active peptides, including μ-receptor-selective opioid analogs, activated protein C inhibitors, and histone deacetylase inhibitors. 2-Aminoindan-2-carboxylic acid can be used in the research of autoimmune diseases, inflammatory diseases, opioid receptor-related diseases, antidiuresis-related diseases, and cancers .

HY-10596R

BMS-688521 (Standard)	Reference Standards Integrin	Inflammation/Immunology
BMS-688521 (Standard) is the analytical standard of BMS-688521 (HY-10596). This product is intended for research and analytical applications. BMS-688521 is a highly potent, orally active inhibitor of the LFA-1/ICAM interaction, with an IC₅₀ of 2.5 nM in the adhesion assay and an IC₅₀ of 60 nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosinophilic lung inflammation model .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992413

MOR102	Integrin	Inflammation/Immunology
MOR102 is a fully human IgG4 monoclonal antibody and an *ICAM-1* inhibitor, lacking cross-reactivity with ICAM-2 and ICAM-3. MOR102 binds to the *LFA-1* binding site within *ICAM-1* domain 1, blocks *ICAM-1/LFA-1* interaction, binds human keratinocytes with increased binding to interferon-γ-stimulated keratinocytes. MOR102 inhibits lymphocyte adhesion, reduces lymphocyte proliferation, prevents local T-cell activation, reduces inflammatory infiltrate, restores orthokeratotic differentiation, and reduces epidermal thickness. MOR102 can be used for the research of psoriasis .

HY-P992053

Anti-CD11a Antibody (MHM24)	Integrin	Inflammation/Immunology
Anti-CD11a Antibody (MHM24) is a monoclonal antibody targeting murine CD11a. Anti-CD11a Antibody (MHM24) binds to high-affinity (open) and low-affinity (closed) conformations of the α_L subunit of *LFA-1, and functionally blocks LFA-1-mediated* interactions. Anti-CD11a Antibody (MHM24) blocks *ICAM-1* binding to LFA-1-expressing cells. Anti-CD11a Antibody (MHM24) inhibits adhesion of high-affinity LFA-1-expressing cells to keratinocytes. Anti-CD11a Antibody (MHM24) inhibits PHA-induced lymphocyte proliferation. Anti-CD11a Antibody (MHM24) can be used for the research of inflammatory and autoimmune diseases. Recommend Isotype Controls: mouse IgG1 kappa, Isotype Control (HY-P99977) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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