27473-62-7
Chemical Structure
2-Aminoindan-2-carboxylic acid
- CAS No.: 27473-62-7
- Formula:C10H11NO2
- Molecular Weight:177.20
IUPAC Name: 2-amino-2,3-dihydro-1H-indene-2-carboxylic acid
InChIKey: UHQFXIWMAQOCAN-UHFFFAOYSA-N
SMILES: O=C(O)C1(N)CC=2C=CC=CC2C1
Biological Activity: 2-Aminoindan-2-carboxylic acid is a conformationally restricted Phenylalanine analog and molecular building block. 2-Aminoindan-2-carboxylic acid constitutes a component of allosteric LFA-1 antagonists targeting the LFA-1/ICAM-1 interaction. 2-Aminoindan-2-carboxylic acid serves as a molecular building block for various biologically active peptides, including μ-receptor-selective opioid analogs, activated protein C inhibitors, and histone deacetylase inhibitors. 2-Aminoindan-2-carboxylic acid can be used in the research of autoimmune diseases, inflammatory diseases, opioid receptor-related diseases, antidiuresis-related diseases, and cancers[1][2].
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2-Aminoindan-2-carboxylic acid | 2-Aminoindan-2-carboxylic acid is a conformationally restricted Phenylalanine analog and molecular building block. 2-Aminoindan-2-carboxylic acid constitutes a component of allosteric LFA-1 antagonists targeting the LFA-1/ICAM-1 interaction. 2-Aminoindan-2-carboxylic acid serves as a molecular building block for various biologically active peptides, including μ-receptor-selective opioid analogs, activated protein C inhibitors, and histone deacetylase inhibitors. 2-Aminoindan-2-carboxylic acid can be used in the research of autoimmune diseases, inflammatory diseases, opioid receptor-related diseases, antidiuresis-related diseases, and cancers. | |||||||||||||||||||||
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- [1]. Kollmann CS, et al. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Bioorg Med Chem. 2014;22(7):2353-2365. [Content Brief]
- [2]. Kotha S, et al. Design, Synthesis and Late-Stage Modification of Indane-Based Peptides via [2+2+2] Cyclotrimerization. Chem Asian J. 2021;16(22):3649-3657. [Content Brief]
Keywords
