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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Lymphocyte specific kinase
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Lymphocyte specific kinase" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
Lck Inhibitor is a potent, orally active Lck (lymphocyte specific kinase) inhibitor with IC50s of 7, 2.1, 4.2 and 200 nM for Lck, Lyn, Src and Syk kinases, respectively. Lck Inhibitor shows >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Lck Inhibitor inhibits T cell proliferation and in vivo models of arthritis .
Cat. No.: HY-175280
CAS No.: 3095033-62-5
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Lck degrader-1 (Compound 17) is a molecular glue degrader targeting lymphocyte-specific protein tyrosine kinase (LCK) (DC50=23.1 nM). Lck degrader-1 is promising for research of T-cell acute lymphoblastic leukemia (T-ALL) .
Cat. No.: HY-180888
CAS No.: 1356734-45-6
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Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase (LCK) inhibitor. Lck-IN-5 selectively disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, thereby impairing LCK recruitment to the TCR. Lck-IN-5 modulates the activity of CD3ε-containing CAR and TRuC T cells, attenuating cytokine production and promoting a central-memory-like phenotype associated with enhanced persistence. Lck-IN-5 can be used for autoimmune diseases and graft-versus-host disease research .
Cat. No.: HY-112335
CAS No.: 1188890-30-3
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Lck Inhibitor III is a Lck inhibitor with an IC50 of 867 nM. Lck Inhibitor III inhibits the production of interleukin-2 (IL-2). Lck Inhibitor III can be used in the study of autoimmune diseases .
Cat. No.: HY-163278
CAS No.: 2615173-24-3
Lck-IN-2 (compound 12a) is an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck) with IC50 of 10.6 nM. Lck-IN-2 reveals efficacy in colon cancer cells with GI50s of 0.24-1.26 μM. Lck-IN-2 exhibits an apoptotic effect in Colo201 cells .
Cat. No.: HY-12135
CAS No.: 1239513-63-3
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Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research .
Cat. No.: HY-P85555
Synonyms: LCK; Lck p56; LCK_HUMAN; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell specific protein tyrosine kinase; Lymphocyte cell-specific protein-tyrosine kinase; Lymphocyte specific Protein Tyrosine kinase; Membrane associated protein tyrosine kinase; Oncogene lck; P56 LCK; p56; LSTRA; protein tyrosine kinase; p56-LCK; p56lck; pp58 lck; pp58lck; Protein YT16; Proto oncogene tyrosine protein kinase LCK; Proto-oncogene Lck; Protooncogene tyrosine protein kinase LCK; T cell specific protein tyrosine kinase; T cell-specific protein-tyrosine kinase; T Lymphocyte specific protein tyrosine kinase p56lck; Tyrosine-protein kinase Lck; YT 16; YT16.
Cat. No.: HY-P702723
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: LCK; P56(LSTRA) Protein-Tyrosine kinase; LCK Proto-Oncogene, Src Family Tyrosine kinase; Tyrosine-Protein kinase; Lymphocyte Cell-specific Protein-Tyrosine kinase; Proto-Oncogene Lck; T Cell-specific Protein-Tyrosine kinase; Protein YT16; Leukocyte C-Terminal Src kinase; Pp58lck; Tyrosine-Protein kinase Lck; P56-LCK; LSK; P56lck; T-Lymphocyte specific Protein Tyrosine kinase P56lck; IMD22; Lymphocyte-specific Protein Tyrosine kinase; YT16; Proto-Oncogene Tyrosine-Protein kinase LCK
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P86477
Synonyms: LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK
Cat. No.: HY-P85255
Synonyms: LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK
Cat. No.: HY-P80743A
Synonyms: LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK
Cat. No.: HY-P705567
Synonyms: LCK; P56(LSTRA) Protein-Tyrosine kinase; LCK Proto-Oncogene, Src Family Tyrosine kinase; Tyrosine-Protein kinase; Lymphocyte Cell-specific Protein-Tyrosine kinase; Proto-Oncogene Lck; T Cell-specific Protein-Tyrosine kinase; Protein YT16; Leukocyte C-Term
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P73269
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LCK; P56(LSTRA) Protein-Tyrosine kinase; LCK Proto-Oncogene, Src Family Tyrosine kinase; Tyrosine-Protein kinase; Lymphocyte Cell-specific Protein-Tyrosine kinase; Proto-Oncogene Lck; T Cell-specific Protein-Tyrosine kinase; Protein YT16; Leukocyte C-Term
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P76946
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAP4K2; B Lymphocyte Serine/Threonine Protein kinase; Prev. RAB8IP; Non-specific Serine/Threonine Protein kinase; GCK; Germinal Centre kinase (GC kinase); BL44; Rab8 Interacting Protein; MAPK/ERK kinase kinase kinase 2; Rab8-Interacting Protein; MEK Kinas
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-112448
CAS No.: 918870-43-6
Target:
Research Areas:
Lck-IN-6 (Compound 12g) is a Lck inhibitor with an IC50 of 3 nM. Lck-IN-6 inhibits the production of IL-2. Lck-IN-6 can be used in the research of rheumatoid arthritis and inflammatory bowel disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
