Search Result

Isoforms Recommended:	Mcl-1

Results for "

MCL1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) ADC Payload (1) Akt (6) Antibiotic (1) Apoptosis (86) Autophagy (7) Bacterial (4) Bcl-2 Family (143) Beta-lactamase (1) BMI1 (1) Btk (2) c-Myc (13) Carbonic Anhydrase (1) Casein Kinase (2) Caspase (14) CD19 (1) CD20 (1) CDK (32) Ceramidase (1) COX (2) CXCR (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (10) Drug Derivative (1) Drug Isomer (6) DYRK (2) ERK (1) Fc Receptor (FcR) (1) FLT3 (1) Fungal (4) GABA Receptor (2) GSK-3 (4) HDAC (1) HIV (1) IAP (3) Isotope-Labeled Compounds (1) JAK (3) JNK (1) Ligands for Target Protein for PROTAC (1) LPL Receptor (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) MMP (1) MNK (1) Molecular Glues (1) mTOR (3) Necroptosis (1) NF-κB (2) Organoid (1) P-glycoprotein (1) p38 MAPK (1) PARP (4) PDGFR (1) Phosphatase (2) PI3K (1) Pim (1) PIN1 (1) PROTAC Linkers (1) PROTACs (7) Reactive Oxygen Species (ROS) (5) Reference Standards (12) ROS Kinase (1) RSV (2) Ser/Thr Kinase (1) SF3B1 (1) Small Interfering RNA (siRNA) (3) Src (1) STAT (9) Survivin (6) Syk (3) Topoisomerase (1) VEGFR (1) Virus Protease (1) Wnt (1)
By Research Areas:	Cancer (178) Cardiovascular Disease (3) Infection (8) Inflammation/Immunology (16) Metabolic Disease (6) Neurological Disease (9)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

190

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100741

S63845 105+ Cited Publications	Bcl-2 Family	Cancer
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a K_d of 0.19 nM for human MCL1 ^[1].

HY-112218

MIK665 15+ Cited Publications S-64315	Bcl-2 Family	Cancer
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 *(MCL1)* inhibitor ^[1]. MIK665 has an IC₅₀ of 1.81 nM for MCL1 .

HY-101533

AZD-5991 15+ Cited Publications	Bcl-2 Family	Cancer
AZD-5991 is a potent and selective *Mcl-1* inhibitor with an IC₅₀ of 0.7 nM in FRET assay and a K_d of 0.17 nM in surface plasmon resonance (SPR) assay ^[1].

HY-18628

UMI-77 4 Publications Verification	Bcl-2 Family	Cancer
UMI-77 is a selective *Mcl-1* inhibitor, which shows high binding affinity to *Mcl-1* (IC₅₀=0.31 μM). UMI-77 binds to the BH3 binding groove of *Mcl-1* with K_i of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-12422

Voruciclib	CDK	Cancer
Voruciclib is an orally active and selective CDK inhibitor with K_i values of 0.626 nM-9.1 nM. Voruciclib potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) ^[1].

HY-125877

*PROTAC Mcl1* degrader-1** 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively *Mcl-1* (Bcl-2 family member) inhibitor with an IC₅₀ of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC₅₀ of 0.54 μM ^[1].

HY-149672

ABBV-467	Bcl-2 Family Apoptosis	Cancer
ABBV-467 is a selective *MCL-1* inhibitor (K_i: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma ^[1].

HY-12468

A-1210477 15+ Cited Publications	Bcl-2 Family Apoptosis	Cancer
A-1210477 is a potent and selective inhibitor of *MCL-1* with a K_i of 0.45 nM ^[1]. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner .

HY-101565

Tapotoclax 5+ Cited Publications AMG-176	Bcl-2 Family	Cancer
Tapotoclax (AMG-176) is a potent, selective and orally active *MCL-1* inhibitor, with a K_i of 0.13 nM ^[1] .

HY-W008296

NH2-C6-NH-Boc	PROTAC Linkers	Cancer
NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC ^[1].

HY-132307

Mcl-1 inhibitor 6	Bcl-2 Family Apoptosis	Cancer
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a K_d of 0.23 nM and a K_i of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, K_d>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent ^[1].

HY-162858

BRD-810	Bcl-2 Family Caspase Apoptosis	Cancer
BRD-810 is a potent and selective *MCL1* inhibitor with a K_d of 0.3 nM. BRD-810 can specifically block the BH3 binding groove of MCL1, while having little effect on other anti-apoptotic proteins (such as Bcl-2, Bcl-xL). BRD-810 effectively destroys the MCL1-BAK complex (IC₅₀ = 1.2 nM) in cancer cells, rapidly activates Caspase and induces cell apoptosis. BRD-810 can be used in the research of various cancers such as hematological tumors and solid tumors ^[1].

HY-112859

VU0661013	Bcl-2 Family	Cancer
VU661013 is a potent and selective *MCL-1* inhibitor.

HY-12020

TW-37 4 Publications Verification	Bcl-2 Family	Cancer
TW-37 is a potent Bcl-2 inhibitor with K_i values of 260, 290 and 1110 nM for *Mcl-1, Bcl-2* and Bcl-xL, respectively.

HY-15613

Maritoclax 5+ Cited Publications Marinopyrrole A	Bcl-2 Family	Cancer
Maritoclax (Marinopyrrole A) is a novel and specific *Mcl-1* inhibitor with an IC₅₀ value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC₅₀ > 80 μM).

HY-16695

MIM1 Inhibitor of MCL-1	Bcl-2 Family	Cancer
MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).

HY-129700

MCL-1/BCL-2-IN-2	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor ^[1].

HY-128360

dMCL1-2	PROTACs Bcl-2 Family Apoptosis Caspase	Cancer
dMCL1-2 is a potent, selective *MCL1* PROTAC degrader based on a Cereblon ligand, with a K_D value of 30 nM for binding to MCL1. dMCL1-2 induces ubiquitination and degradation of MCL1. dMCL1-2 degrades MCL1, cleaves Caspase-3, and induces Apoptosis. dMCL1-2 can be used in research related to multiple myeloma ^[1].

HY-109184

Murizatoclax 1 Publications Verification AMG 397	Bcl-2 Family	Cancer
Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a K_i of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer ^[1] .

HY-129478

TC11 2 Publications Verification	Caspase Bcl-2 Family CDK	Cancer
TC11 is a *MCL1* degrader and Caspase-9 and *CDK1* activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of *MCL1* leading to apoptotic death ^[1] during prolonged mitotic arrest.

HY-155472

Mcl-1 inhibitor 17	Bcl-2 Family	Cancer
Mcl-1 inhibitor 17 is a Mcl-1 protein inhibitor. Mcl-1 inhibitor 17 can be used for the research of cancer and other diseases ^[1].

HY-15464

(R)-(-)-Gossypol 3 Publications Verification AT-101; R-(-)-gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, *Mcl-1* and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-15464A

(R)-(-)-Gossypol acetic acid 5+ Cited Publications AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid	Bcl-2 Family Autophagy	Cancer
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, *Mcl-1* and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-129702

MCL-1/BCL-2-IN-4	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor ^[1].

HY-129681

MCL-1/BCL-2-IN-1	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively ^[1].

HY-13408

(+)-Apogossypol Apogossypol; NSC736630	Bcl-2 Family	Cancer
(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to *Mcl-1, Bcl-2* and Bcl-xL with EC₅₀s of 2.6, 2.8 and 3.69 µM, respectively.

HY-16669

Mcl1-IN-1	Bcl-2 Family	Cancer
Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC₅₀=2.4 µM).

HY-RS08230

MCL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
MCL1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCL1 Human Pre-designed siRNA Set A MCL1 Human Pre-designed siRNA Set A

HY-12527

Pyridoclax 1 Publications Verification MR-29072	Bcl-2 Family	Cancer
Pyridoclax is a potential *Mcl-1* inhibitor.

HY-12422A

Voruciclib hydrochloride	CDK	Cancer
Voruciclib hydrochloride is an orally active and selective CDK inhibitor with K_i values of 0.626 nM-9.1 nM. Voruciclib hydrochloride potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib hydrochloride represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) ^[1].

HY-100741A

(S,R)-S63845	Bcl-2 Family	Cancer
(S,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a K_d of 0.19 nM for human MCL1 ^[1].

HY-112591

NSC260594 XMH95	Apoptosis HIV Wnt Bcl-2 Family	Cancer
NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the *Mcl-1* protein, and inhibits Mcl-1 expression through down-regulation of Wnt signaling proteins. NSC260594 can also recognize G9-G10-A11-G12 RNA tetraloop of HIV and prevent the binding of the Gag protein within the 5’-UTR. NSC260594 inhibits tumor growth, and can be used for research of Triple-negative breast cancers (TNBCs) ^[1].

HY-148203

Mcl-1 inhibitor 9	Bcl-2 Family	Cancer
Mcl-1 inhibitor 9 (example 2) is a myeloid cell leukemia 1 (Mcl-1) inhibitor with IC₅₀ value of 0.21889 nM. Mcl-1 inhibitor 9 shows anti-tumor activity ^[1].

HY-145825

Mcl-1 inhibitor 7	Bcl-2 Family	Cancer
Mcl-1 inhibitor 7 is a potent *Mcl-1* inhibitor, example 35, extracted from patent WO2020097577A ^[1].

HY-163681

Zamzetoclax	Bcl-2 Family	Cancer
Zamzetoclax (compound 1) is a potential *Mcl-1* inhibitor ^[1].

HY-100741C

(R,R)-S63845	Bcl-2 Family Drug Isomer	Cancer
(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a K_d of 0.19 nM for human MCL1 ^[1].

HY-101533A

AZD-5991 Racemate	Bcl-2 Family	Cancer
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a *Mcl-1* inhibitor with an IC₅₀ of <3 nM in FRET assay.

HY-101533B

AZD-5991 (S-enantiomer)	Bcl-2 Family	Cancer
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a *Mcl-1* inhibitor with an IC₅₀ of 6.3 μM in FRET assay and a K_d of 0.98 μM in surface plasmon resonance (SPR) assay.

HY-145826

Mcl-1 inhibitor 8	Bcl-2 Family	Cancer
Mcl-1 inhibitor 8 is a *MCL-1* inhibitor, example 228, extracted from patent WO2019222112 ^[1].

HY-120113

SC-2001	Apoptosis Bcl-2 Family STAT	Others
SC-2001 is a compound structurally related to obatoclax that has better antitumor effects than obatoclax in liver cancer cell lines, downregulating Mcl-1 protein levels, inhibiting STAT3 phosphorylation, inducing apoptosis, and enhancing SHP1 expression and activity.

HY-163293

Mcl-1 inhibitor 18	Bcl-2 Family	Cancer
Mcl-1 inhibitor 18 (compound 57) is a myeloid cell leukemia 1 (Mcl-1) inhibitor, and can be used for study of cancer ^[1].

HY-133015

Mcl-1 inhibitor 3	Bcl-2 Family	Cancer
Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic *Mcl-1* inhibitor (K_i= 0.061 nM; IC₅₀=19 nM in an OPM-2 cell viability assay). Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity ^[1]. .

HY-129701

MCL-1/BCL-2-IN-3	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor with IC₅₀s of 5.95 and 4.78 μM, respectively ^[1].

HY-RS08231

Mcl1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Mcl1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mcl1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mcl1 Mouse Pre-designed siRNA Set A Mcl1 Mouse Pre-designed siRNA Set A

HY-148899

Mcl-1 inhibitor 10	Bcl-2 Family	Cancer
Mcl-1 inhibitor 10 (compound 43) is a relatively strong *MCL-1* inhibitor (IC₅₀=0.67 μM). Mcl-1 inhibitor 10 interacts with specific binding sites of *MCL-1* protein to block the pro-survival signal of *MCL-1* and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of *MCL-1* dependent cancers ^[1].

HY-170763B

*(-)-Mcl-1* inhibitor 22**	Bcl-2 Family Apoptosis	Cancer
(-)-Mcl-1 inhibitor 22 (compound 38) is an *Mcl-1* inhibitor that works by blocking the interaction between *Mcl-1* and pro-apoptotic proteins, reducing the anti-apoptotic activity of *Mcl-1. (-)-Mcl-1* inhibitor 22 can be used in cancer research ^[1].

HY-150507

JNJ-4355 JNJ-78394355	Bcl-2 Family	Cancer
JNJ-4355, a chemical probe, is a highly potent *MCL-1* (myeloid cell leukemia-1) inhibitor, with K_I of 18 pM. JNJ-4355 shows antitumor activity ^[1] .

HY-159588

Mcl-1 inhibitor 20	Bcl-2 Family	Cancer
Mcl-1 inhibitor 20 (compound 47) is a *Mcl-1* inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity ^[1].

HY-153423

Mcl-1 inhibitor 12	Bcl-2 Family	Cancer
Mcl-1 inhibitor 12 (Example 10) is a *MCL-1* inhibitor (K_i: 0.22 nM). Mcl-1 inhibitor 12 can be used for the research of cancers ^[1].

HY-153423A

Mcl-1 inhibitor 13	Bcl-2 Family	Cancer
Mcl-1 inhibitor 13 (Example 9) is a *MCL-1* inhibitor (K_i: 8.2 nM). Mcl-1 inhibitor 13 can be used for the research of cancers ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian ^[1] .

HY-P4095

NoxaBH3	CXCR	Cancer
NoxaBH3 is a cysteine-based cross-linked peptide with increased cell permeability and higher inhibitory activity against Mcl-1. NoxaBH3 binds to the endogenous CXCR4 ligand to produce ubiquitin-Noxabh3 conjugate. NoxaBH3 is then delivered to cancer cells ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P991225

BI-1206	Fc Receptor (FcR) CD20	Inflammation/Immunology Cancer
BI-1206 is a recombinant and antagonistic human monoclonal antibody targeting FcγRIIB (CD32B). BI-1206 can block CD20 internalization induced by Rituximab (HY-P9913) itself or combined with others including Ibrutinib (HY-10997), Venetoclax (HY-15531), and CHOP. BI-1206 can enhance or recover the activity of Rituximab or other anti-CD20 monoclonal antibodies. BI-1206 has cytolytic activity against malignant B cells. BI-1206 can be studied for cancer research such as mantle cell lymphoma (MCL) .

HY-P991899

IKS03 Antibody LCB73 Antibody	ADC Antibody CD19	Cancer
IKS03 Antibody (LCB73 Antibody) is an anti-human CD19 antibody. IKS03 Antibody can generate antibody drug conjugate (ADC) (IKS03) with a pyrrolobenzodiazepine (PBD) dimer payload. IKS03 Antibody can be used for the study of diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0662

Amentoflavone Maximum Cited Publications 18 Publications Verification Didemethyl-ginkgetin	Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[1] .

HY-N0087

Gambogic Acid 5+ Cited Publications Beta-Guttiferrin	Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, *Bfl-1* and *Mcl-1* with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N0831

Jaceosidin 5+ Cited Publications	Laburnum anagyroides Medic. Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Bcl-2 Family COX Apoptosis
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression ^[1]. Jaceosidin exhibits anti-cancer , anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation .

HY-W040129

Chromomycin A3 1 Publications Verification	Microorganisms Source Classification	DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase
Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of *Sp1* transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe ^[1] .

HY-N0763

Angelicin 10+ Cited Publications Isopsoralen	Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and *Mcl-1, while activating caspase-9* and caspase-3.

HY-118341

Clitocine	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	Apoptosis Bcl-2 Family
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity ^[1] .

HY-15464

(R)-(-)-Gossypol 3 Publications Verification AT-101; R-(-)-gossypol acetic acid	Malvaceae Classification of Application Fields Gossypium Phenols Plants Disease Research Fields Cancer Source Classification	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, *Mcl-1* and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification Cancer	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of *MCL-1, PTTG1, survivin* and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells ^[1] .

HY-N3913

Furowanin A	Flavonoids Leguminosae Plants Derris taiwaniana (Hayata) Z. Q. Song Isoflavones Source Classification	STAT Bcl-2 Family
Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits *STAT3/Mcl-1* axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells ^[1].

HY-N17676

3-Tridecylphenol	Structural Classification Monophenols Ginkgoaceae Phenols Plants Ginkgo biloba Source Classification	Bcl-2 Family
3-Tridecylphenol is a cardanol. 3-Tridecylphenol can be isolated from K. hookeriana. 3-Tridecylphenol shows K_i values of >23 μM and >33 μM in BclxL/Bak and *Mcl-1/Bid* displacement assays, respectively. 3-Tridecylphenol can be used in cancer research ^[1].

HY-N0662R

Amentoflavone (Standard) Didemethyl-ginkgetin (Standard)	Structural Classification Flavonoids Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Source Classification	Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[1] .

HY-N0831R

Jaceosidin (Standard)	Laburnum anagyroides Medic. Flavonoids Classification of Application Fields Phenols Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Bcl-2 Family COX Apoptosis
Jaceosidin (Standard) is the analytical standard of Jaceosidin. This product is intended for research and analytical applications. Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression ^[1]. Jaceosidin exhibits anti-cancer , anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation .

HY-N0087R

Gambogic Acid (Standard) Beta-Guttiferrin (Standard)	Structural Classification Natural Products Guttiferae Plants Garcinia hanburyi Hook. f.	Reference Standards Bcl-2 Family Autophagy
Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-W040129R

Chromomycin A3 (Standard)	Microorganisms Source Classification	Reference Standards Bacterial Fungal Apoptosis Antibiotic
Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of *Sp1* transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe ^[1] .

HY-N16746

Nordentatin	Structural Classification Rutaceae Coumarins Phenylpropanoids Plants Clausena excavata N. L. Burman Source Classification	GSK-3 Bcl-2 Family MMP Caspase
Nordentatin is a selective inhibitor targeting GSK-3 with anticancer activity. Nordentatin can inhibit the phosphorylation of GSK-3, downregulate the anti-apoptotic protein *Mcl-1* and activate caspase-3 to induce apoptosis (apoptosis). Nordentatin also inhibits the expression of migration-related protein MMP-9 and exerts anti-proliferation and anti-migration activities. Nordentatin is used in research into cancers such as neuroblastoma ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

Host:	Mouse (2) Rabbit (4)
Reactivity:	Human (6) Rat (3) Mouse (4)
Application:	IHC-P (5) ICC/IF (6) IP (3) WB (6) FC (3) ELISA (3)
Isotype:	IgG (3) IgG1 (2) IgG/Kappa (1)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (3)
Modification:	Unmodified (5)

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HY-P86177

	MCL1 Antibody (YA5869) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein MCL-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/MCL1; MCL1/EAT	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MCL1 Antibody (YA5869) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCL1.

HY-P85269

	MCL1 Antibod (YA4961) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein MCL-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/MCL1; MCL1/EAT	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	MCL1 Antibody (YA4961) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to MCL1.

HY-P80508

	MCL1 Antibody (YA303)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	MCL1 Antibody (YA303) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCL1.

HY-P84507

	MCL1 Antibody (YA4204) EAT, MCL1L, MCL1S	WB, IHC-P, ICC/IF, ELISA	Human
	MCL1 Antibody (YA4204) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCL1.

HY-P84507A

	MCL1 Antibody (YA4204)(PBS only) EAT, MCL1L, MCL1S	WB, IHC-P, ICC/IF, ELISA	Human
	MCL1 Antibody (YA4204) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCL1.

HY-P86907

	HUWE1 Antibody (YA6600) ARF binding protein 1 antibody; ARF BP1 antibody; ARF-binding protein 1 antibody; ARF-BP1 antibody; ARFBP1 antibody; BJ-HCC-24 tumor antigen antibody; E3 ubiquitin protein ligase HUWE1 antibody; E3 ubiquitin-protein ligase HUWE1 antibody; HECT antibody; HECT domain protein LASU1 antibody; ARF binding protein 1 antibody; ARF BP1 antibody; ARF-binding protein 1 antibody; ARF-BP1 antibody; ARFBP1 antibody; BJ-HCC-24 tumor antigen antibody; E3 ubiquitin protein ligase HUWE1 antibody; E3 ubiquitin-protein ligase HUWE1 antibody; HECT antibody; HECT domain protein LASU1 antibody; HECT UBA and WWE domain containing protein 1 antibody; HectH9 antibody; Homologous to E6AP carboxyl terminus homologous protein 9 antibody; Huwe1 antibody; HUWE1_HUMAN antibody; Ib772 antibody; Large structure of UREB1 antibody; LASU1 antibody; MCL 1 ubiquitin ligase E3 antibody; MCL-1 ubiquitin ligase E3 antibody; Mule antibody; UBA and WWE domain-containing protein 1 antibody; Upstream regulatory element-binding protein 1 antibody; URE-B1 antibody; URE-binding protein 1 antibody; UREB1 antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	HUWE1 Antibody (YA6600) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HUWE1.

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