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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
MCTS1
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "MCTS1" in MCE Product Catalog:
92
92 Publications Verification
Target:
Forschungsgebiete:
AZD3965 is a selective MCT1 inhibitor with a Ki of 1.6 nM, showing 6-fold selectivity over MCT2.
52
52 Cited Publications
Target:
Forschungsgebiete:
AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively.
16
Target:
Forschungsgebiete:
Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine [1] .
10
10 Cited Publications
Art. -Nr.: HY-D0067
CAS. Nr.: 50995-74-9
Synonyms: DEAC; Coumarin D 1421; D 1421
Target:
Forschungsgebiete:
7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers [1] .
8
8 Cited Publications
Target:
Forschungsgebiete:
VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism [1].
5
5 Cited Publications
Target:
Forschungsgebiete:
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity [1].
2
2 Cited Publications
Art. -Nr.: HY-18974
CAS. Nr.: 227321-12-2
Target:
Forschungsgebiete:
MCT1-IN-2 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. MCT1-IN-2 has anti-cancer activity [1] .
1
1 Cited Publications
Target:
Forschungsgebiete:
GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a Ki <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC [1].
1
1 Cited Publications
Target:
Forschungsgebiete:
AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pKi values of 7.6, 6.6 for MCT-1 and MCT-2, respectively [1]. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response .
Target:
Forschungsgebiete:
MCT-IN-1 (Compound 2) is a potent MCT inhibitor, with IC50 values of 9 nM and 14 nM against MCT1 and MCT4, respectively. MCT-IN-1 can be used in research related to solid tumors [1].
Art. -Nr.: HY-Y1080
CAS. Nr.: 19764-30-8
Synonyms: N-Acetyl-D-leucine
Category:
Target:
Art. -Nr.: HY-RS08251
Target:
Forschungsgebiete:
MCTS1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCTS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-B1804S
CAS. Nr.: 65402-55-3
Synonyms: Trioctanoin-13C3; Glyceryl trioctanoate-13C3
Forschungsgebiete:
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer [1].
Forschungsgebiete:
Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine [1] .
Art. -Nr.: HY-119996
CAS. Nr.: 873327-59-4
Forschungsgebiete:
AR-C141990 (Compound 30) is a potent blocker of the monocarboxylate transporter MCT1 with a Ki of 4.8 nM. AR-C141990 (Compound 30) inhibits CYP3A4 and CYP2C9 with IC50 values of 16 μM [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
