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Art. -Nr.: HY-148574

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MCT1-IN-3

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MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC₅₀ value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer.

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Reinheit: 98.65%
CAS. Nr.: 2878360-80-4
Formel: C₂₂H₁₉N₃O₄
Molecular Weight:389.40

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MCT1-IN-3 Chemical Structure

CAS. Nr.: 2878360-80-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 81.0 nM (MCT1)^[1]
GI50: 20 μM (A-549); 15.1 μM (MCF-7)^[1]

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780 ADR	EC₅₀	0.793 μM Compound: 24	Reversal of multi-drug resistance in human A2780 ADR cells expressing ABCB1 incubated for 72 hrs by MTT assay Reversal of multi-drug resistance in human A2780 ADR cells expressing ABCB1 incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	110 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 3.5 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 3.5 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	214 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 2 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 2 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	32.2 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 5 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 5 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A2780 ADR	GI₅₀	332 nM Compound: 24	Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 1 uM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A2780 ADR cells expressing ABCB1 assessed as doxorubicin at 1 uM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	19.4 nM Compound: 24	Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin IC50 at 500 nM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin IC50 at 500 nM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	20 μM Compound: 24	Antiproliferative activity against human A549 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	27.7 nM Compound: 24	Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 100 nM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 100 nM incubated for 72 hrs by MTT assay	[PMID: 36584238]
A549	GI₅₀	40 nM Compound: 24	Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 50 nM incubated for 72 hrs by MTT assay Induction of doxorubicin sensitization in human A549 cells expressing MCT1 assessed as doxorubicin GI50 at 50 nM incubated for 72 hrs by MTT assay	[PMID: 36584238]
MCF7	GI₅₀	15.1 μM Compound: 24	Antiproliferative activity against human MCF7 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells expressing MCT1 assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 36584238]

In Vitro

MCT1-IN-3 (compound 24) has inhibitory activity for MCT1 with an IC₅₀ value of 81.0 nM^[1].
MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI₅₀ values of 20 μM and 15.1 μM, respectively^[1].
MCT1-IN-3 (5 μM; 24 h) leads to cancer cell cycle arrest as well as apoptosis^[1].
MCT1-IN-3 (1.0, 2.0, 3.5, and 5.0 μM) shows to sensitize these cancer cells toward an antineoplastic agent^[1].
MCT1-IN-3 has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

A-549 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.

Apoptosis Analysis^[1]

Cell Line:

A-549 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.

Chemical Information

CAS. Nr. 2878360-80-4
Appearance Solid
Molecular Weight 389.40
Formel C₂₂H₁₉N₃O₄
Color Off-white to light yellow
SMILES

COC(/C(C#N)=C/C1=CN(C2=CC=CC=C12)CC(NC3=CC=C(C=C3)OC)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sachin Puri, et al. Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). J Med Chem. 2023 Jan 12;66(1):657-676. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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MCT1-IN-3

Anti-Cancer Metabolism Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Drug-Resistant Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MCT1-IN-3

Anti-Cancer Metabolism Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Drug-Resistant Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MCT1-IN-3 Related Classifications

HY-148574 Related Classifications