1. Membrane Transporter/Ion Channel
  2. Monocarboxylate Transporter P-glycoprotein
  3. MCT1-IN-3

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer.

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MCT1-IN-3 Chemical Structure

MCT1-IN-3 Chemical Structure

CAS No. : 2878360-80-4

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Description

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC50 value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer[1].

IC50 & Target

IC50: 81.0 nM (MCT1)[1]
GI50: 20 μM (A-549); 15.1 μM (MCF-7)[1]

In Vitro

MCT1-IN-3 (compound 24) has inhibitory activity for MCT1 with an IC50 value of 81.0 nM[1].
MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively[1].
MCT1-IN-3 (5 μM; 24 h) leads to cancer cell cycle arrest as well as apoptosis[1].
MCT1-IN-3 (1.0, 2.0, 3.5, and 5.0 μM) shows to sensitize these cancer cells toward an antineoplastic agent[1].
MCT1-IN-3 has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: A-549 cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Caused a disruption of the cell cycle of A-549 cancer cells, indicated by a shift from the predominant Go/G, phase.

Apoptosis Analysis[1]

Cell Line: A-549 cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Increased the percentage of total apoptotic cells by a factor of 13 from 0.51 to 6.68%.
Molecular Weight

389.40

Formula

C22H19N3O4

CAS No.
SMILES

COC(/C(C#N)=C/C1=CN(C2=CC=CC=C12)CC(NC3=CC=C(C=C3)OC)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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MCT1-IN-3
Cat. No.:
HY-148574
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