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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
NADH oxidation
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "NADH oxidation" in MCE Product Catalog:
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1 Cited Publications
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KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
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MS-L6 is a OXPHOS inhibitor and antimalarial agent. MS-L6 inhibits NADH oxidation and electron transport. MS-L6 induces OXPHOS uncoupling, dissipates mitochondrial membrane potential, increases non-ATP-coupled oxygen consumption, and reduces ATP synthesis. MS-L6 triggers the production of ROS. MS-L6 exhibits anti-amoebic activity. MS-L6 exerts antitumor activity in mouse lymphoma xenograft models. MS-L6 can be used in research related to B-cell lymphoma, T-cell lymphoma, and non-Hodgkin B-cell lymphoma .
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Beta-galactose dehydrogenase is a selective catalyst for β-galactose. Under pH 8.6 conditions, beta-galactose dehydrogenase catalyzes the oxidation of β-galactose, produced by the hydrolysis of lactose by β-galactosidase, with nicotinamide adenine dinucleotide (NAD) to produce reduced nicotinamide adenine dinucleotide (NADH). Beta-galactose dehydrogenase specifically mediates this oxidation reaction for the quantitative detection of the substrate, used in the analysis of lactose concentration in samples such as breast milk .
Cat. No.: HY-N7151
CAS No.: 108354-13-8
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Glucose dehydrogenase, recombinant Microorganisms is a FDA-dependent oxidoreductase. Glucose dehydrogenase (GDH) catalyzes the oxidation of β-D-glucose to β-D-glucono-1,5-lactone with simultaneous reduction of the cofactor NADP + to NADPH or, to a lesser extent, NAD + to NADH. Glucose dehydrogenase (GDH) accepts both NAD + and NADP + as cofactors and can be used for the regeneration of NADH and NADPH .
Synonyms: GPDH; α-Glycerophosphate dehydrogenase; Glycerol phosphate dehydrogenase
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Glycerol-3-phosphate dehydrogenase, rabbit muscle (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. Glycerol-3-phosphate dehydrogenase is a glycolytic enzyme and is responsible for the re-oxidation of NADH to NAD + and energy supply .
Cat. No.: HY-B1044
CAS No.: 20098-14-0
Synonyms: Kemantane; 5-Hydroxy-2-adamantanone
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Idramantone (Kemantane, 5-Hydroxy-2-adamantanone) is an adamantane-based immunomodulator. Idramantone increases the activity of T helper cells by 1.5 to 2-fold, but exerts no significant effect on the functional activity, induction or accumulation of antigen-specific T suppressor cells. Idramantone serves as a key intermediate for the synthesis of various adamantane derivatives, and can be produced via the regioselective oxidation of 2-adamantanone catalyzed by P450cam monooxygenase, a process that relies on an NADH regeneration system to provide reducing equivalents. Idramantone can be used in studies related to immunomodulation .
Cat. No.: HY-161685
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Antibiofilm agent-8 (compound Ru2) enhances antimicrobial activity on visible-light exposure (400-700 nm, 10 J cm-2). Antibiofilm agent-8 generates of oxidative stress via NADH oxidation and ROS generation and compromises bacterial wall .
Synonyms: GPDH, microorganism; α-Glycerophosphate dehydrogenase, microorganism; Glycerol phosphate dehydrogenase, microorganism
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Glycerol-3-phosphate dehydrogenase, microorganism (GPDH, microorganism) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate.Glycerol-3-phosphate dehydrogenase is a glycolytic enzyme and is responsible for the re-oxidation of NADH to NAD + and energy supply .
Cat. No.: HY-W008646R
CAS No.: 6779-87-9
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Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a Ki of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism .
Cat. No.: HY-131829
CAS No.: 59587-50-7
Synonyms: 6-AE-NAD+
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N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) is an adenine-modified NAD analog with coenzyme activity and the property of targeting lactate dehydrogenase (LDH). N6-(2-Aminoethyl)-NAD+ undergoes transient affinity binding with LDH, thereby crosslinking the enzyme monolayer into an integrated electrode. N6-(2-Aminoethyl)-NAD + is a component of the PQQ (HY-100196)-NAD + binary interface, and supports the bioelectrocatalytic oxidation of lactate through PQQ-mediated immobilized NADH oxidation .
Cat. No.: HY-F0001A
CAS No.: 1949720-50-6
Synonyms: Disodium NADH hydrate
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NADH disodium salt (Disodium NADH) hydrate is an orally active reduced coenzyme. NADH disodium salt hydrate is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt hydrate plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .
Cat. No.: HY-128895A
CAS No.: 1800406-26-1
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KL1333 hydrochloride is an orally active NAD + modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD + levels through NADH oxidation. Elevated NAD + levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .
Cat. No.: HY-131829A
Synonyms: 6-AE-NAD+ sodium
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N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) sodium is an adenine-modified NAD analog with coenzyme activity and the property of targeting lactate dehydrogenase (LDH). N6-(2-Aminoethyl)-NAD+ sodium undergoes transient affinity binding with LDH, thereby crosslinking the enzyme monolayer into an integrated electrode. N6-(2-Aminoethyl)-NAD + is a component of the PQQ (HY-100196)-NAD + binary interface, and supports the bioelectrocatalytic oxidation of lactate through PQQ-mediated immobilized NADH oxidation .
Cat. No.: HY-W032878
CAS No.: 2372-82-9
N,N-Bis(3-aminopropyl)dodecylamine is a potent fungicidal agent with remarkable activity against Aspergillus niger. N,N-Bis(3-aminopropyl)dodecylamine induces oxidative stress and regulates the activities of multiple antioxidant and mitochondrial enzymes in a concentration‑ and duration‑dependent manner. N,N-Bis(3-aminopropyl)dodecylamine disrupts fungal organelles, remodels mitochondrial morphology and impairs mitochondria‑related cellular functions. N,N-Bis(3-aminopropyl)dodecylamine can be used for the research of fungicidal mechanisms and oxidative stress in Aspergillus niger .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
