6779-87-9
6779-87-9
Chemical Structure
7,8-Dihydro-L-biopterin
Synonym(s): Dihydrobiopterin
- No. CAS: 6779-87-9
- Formula:C9H13N5O3
- Molecular Weight:239.23
IUPAC Name: 2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-7,8-dihydropteridin-4(1H)-one
InChIKey: FEMXZDUTFRTWPE-DZSWIPIPSA-N
SMILES: O=C1N=C(N)NC2=C1N=C([C@@H](O)[C@@H](O)C)CN2
Biological Activity: 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases[1][2][3][4].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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7,8-Dihydro-L-biopterin | 99.79% | 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases. | ||||||||||||||||||||
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7,8-Dihydro-L-biopterin (Standard) | 96.47% | 7,8-Dihydro-L-biopterin (Standard) (Dihydrobiopterin (Standard)) is the analytical standard of 7,8-Dihydro-L-biopterin (HY-W008646). This product is intended for research and analytical applications. 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases. | ||||||||||||||||||||
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Tetrahydrobiopterin | Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms. | |||||||||||||||||||||
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L-Sepiapterin | 90.48% | L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia. | ||||||||||||||||||||
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Ronopterin | Ronopterin (VAS203) is a NO Synthase inhibitor. Ronopterin can be used in research on diseases of the urogenital system and the nervous system. | |||||||||||||||||||||
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7,8-Dihydroneopterin (Standard) | ≥98% | Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. | ||||||||||||||||||||
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Sapropterin-d3 | Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU). | |||||||||||||||||||||
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T7117 | T7117 is a TRIM25-HIF-1α inhibitor. T7117 disrupts the interaction between TRIM25-HIF-1α. T7117 can be used for the research of glioblastoma. | |||||||||||||||||||||
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Sapropterin | Sapropterin Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active cofactor of phenylalanine hydroxylase (PAH) that effectively reduces blood phenylalanine concentrations. Sapropterin can be used in research on phenylketonuria (PKU). Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE). | |||||||||||||||||||||
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Sapropterin dihydrochloride (Standard) | 99.96% | Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE). | ||||||||||||||||||||
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2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine | 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is a metabolite in the biosynthesis pathway (purine metabolism process) of Riboflavin (HY-B0456). | |||||||||||||||||||||
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(6R)-Tetrahydro-L-biopterin sulfate | (6R)-Tetrahydro-L-biopterin (sulfate) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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References
- [1]. Taylor N E, et al. NO synthase uncoupling in the kidney of Dahl S rats: role of dihydrobiopterin[J]. Hypertension, 2006, 48(6): 1066-1071.
- [2]. Stover J F, et al. Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA)[J]. Journal of neurotrauma, 2014, 31(19): 1599-1606.
- [3]. Espinosa-Mansilla A, et al. LC determination of biopterin reduced forms by UV-photogeneration of biopterin and fluorimetric detection[J]. Talanta, 2008, 77(2): 844-851.
- [4]. Enzinger C, et al. Reduced pteridine derivatives induce apoptosis in PC12 cells. Neurochem Int. 2002;41(1):71-78. [Content Brief]
