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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Nrf2-dependent
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Nrf2-dependent" in MCE Product Catalog:
20
20 Publications Verification
Synonyms: XU 62-320
Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [2] .
20
20 Publications Verification
Synonyms: XU 62-320 free acid
Target:
연구분야:
Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [2] .
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10
2
2 Cited Publications
Cat. No.: HY-N1970
CAS No.: 31721-94-5
Category:
other families Flavonoids Phenols Polyphenols Plants Isoflavones
Target:
1
1 Cited Publications
CPUY192018 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with an IC50 of 0.63 µM. CPUY192018 exhibits anti-inflammatory and antioxidant activities. CPUY192018 can activate the Nrf2-dependent antioxidant pathway and inhibit the NF-κB-related inflammatory response. CPUY192018 can be used in the research of inflammation-related diseases [2].
1
1 Cited Publications
Cat. No.: HY-N7617
CAS No.: 41743-74-2
Category:
Microorganisms Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Phenols Polyphenols Plants Disease Research Fields Cancer
Target:
Cat. No.: HY-159641
CAS No.: 3034880-93-5
Synonyms: BAY-3605349
Target:
VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors [2] .
Cat. No.: HY-14664AS
Purity: 98.98%
Synonyms: XU 62-320-d6
Cat. No.: HY-14664AR
CAS No.: 93957-55-2
Synonyms: XU 62-320 (Standard)
연구분야:
Fluvastatin (sodium) (Standard) is the analytical standard of Fluvastatin (sodium). This product is intended for research and analytical applications. Fluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin sodium protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [2] .
Cat. No.: HY-14664R
CAS No.: 93957-54-1
Synonyms: XU 62-320 free acid (Standard)
Fluvastatin (Standard) is the analytical standard of Fluvastatin. This product is intended for research and analytical applications. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [2] .
Cat. No.: HY-14664B
CAS No.: 155229-75-7
Synonyms: (3R,5S)-XU 62-320 free acid
Target:
연구분야:
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [2] .
Synonyms: (3S,5R)-XU 62-320-d6
Synonyms: (3S,5R)-XU 62-320
Target:
연구분야:
(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .
Cat. No.: HY-171035
CAS No.: 2377770-85-7
PRL-295 is an orally active inhibitor targeting Keap1-Nrf2 interaction. PRL-295 increases the thermal stability of Keap1 and disrupts its interaction with Nrf2, thereby activating the Nrf2-dependent transcriptional target NAD(P)H:quinone oxidoreductase 1 (NQO1). PRL-295 protects against Acetaminophen (HY-66005)-induced liver injury in mice .
Cat. No.: HY-N1970R
CAS No.: 31721-94-5
Category:
other families Flavonoids Phenols Polyphenols Plants Isoflavones
Target:
Cat. No.: HY-14664DS
CAS No.: 2249799-34-4
Synonyms: (3S,5R)-XU 62-320-d6 free acid
Cat. No.: HY-14664D
CAS No.: 201541-53-9
Synonyms: XU 62-320 monohydrate
Target:
연구분야:
Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC50 of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway [2].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
