201541-53-9
201541-53-9
Chemical Structure
Fluvastatin sodium monohydrate
Synonym(s): XU 62-320 monohydrate
- CAS No.: 201541-53-9
- Formula:C24H27FNNaO5
- Molecular Weight:451.46
InChIKey: KKEMYLLTGGQWCE-FFAWTJJMSA-M
SMILES: O=C(O[Na])C[C@@H](O)C[C@@H](O)/C=C/C1=C(C2=CC=C(C=C2)F)C3=CC=CC=C3N1C(C)C.O
Biological Activity: Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC50 of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2].
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Fluvastatin sodium monohydrate | Fluvastatin (XU 62-320) sodium monohydrate is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC50 of 8 nM. Fluvastatin (sodium monohydrate) protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. | |||||||||||||||||||||
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(3S,5R)-Fluvastatin-d6 | (3S,5R)-Fluvastatin-d6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive?HMG-CoA reductase?inhibitor with an IC50?of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. | |||||||||||||||||||||
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References
- [1]. Makabe S, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010;213(2):377-384. [Content Brief]
- [2]. Zhang W, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010;48(12):1167-1174. [Content Brief]
