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Isoforms Recommended:	PKCζ

Results for "

PKCζ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (5) Autophagy (1) Cathepsin (1) CDK (2) ERK (1) Glutathione Peroxidase (1) Isotope-Labeled Compounds (1) JNK (1) MMP (1) mTOR (1) NADPH Oxidase (1) p38 MAPK (2) Phosphatase (1) PKC (15) Protease Activated Receptor (PAR) (1) Pyruvate Kinase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) ROCK (2) SOD (1) Survivin (1)
By Research Areas:	Cancer (11) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (4)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13689

Go 6983 Maximum Cited Publications 82 Publications Verification Gö 6983; Goe 6983	PKC	Cancer
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and *PKCζ* with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

HY-123979

ζ-Stat 3 Publications Verification NSC37044	PKC Apoptosis	Cancer
ζ-Stat (NSC37044) is a specific and atypical *PKC-ζ* inhibitor, with an IC₅₀ of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro .

HY-13626

Spisulosine ES-285	PKC Apoptosis	Cancer
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and *PKCζ* activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-18713

CRT0066854	PKC ROCK	Neurological Disease Inflammation/Immunology
CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, *PKCζ, and ROCK-II* kinases with IC₅₀ values of 132 nM, 639 nM, and 620 nM, respectively .

HY-18713A

CRT0066854 hydrochloride	PKC ROCK	Neurological Disease
CRT0066854 hydrochloride is a potent and selective atypical *PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II* kinases with IC₅₀ values of 132 nM, 639 nM, and 620 nM, respectively .

HY-120497

PKCζ-IN-1	PKC CDK	Cancer
PKCζ-IN-1 is a compound that inhibits PKCζ and CDK2, showing an IC50 value of 5.18 nM for PKCζ and 1.04 μM for CDK2, with significant selectivity of 200-fold. PKCζ-IN-1 can reduce the activity of CDK2 while inhibiting PKCζ.

HY-117366

PS432	PKC	Cancer
PS432 is a *PKC* inhibitor with IC₅₀s of 16.9 μM (PKCι) and 18.5 μM (PKC_ζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lung cancer cells (NSCLCs) and tumor growth in mouse xenograft models .

HY-P3012

Cathepsin G	Cathepsin ERK p38 MAPK PKC Protease Activated Receptor (PAR) MMP	Inflammation/Immunology
Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating *PKCζ* membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases .

HY-123979A

ζ-Stat trisodium 3 Publications Verification NSC37044 trisodium	PKC Apoptosis	Cancer
ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical *PKC-ζ* inhibitor, with an IC₅₀ of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro .

HY-125953

Ceramide (Egg) Ceramide (Egg, Chicken)	JNK p38 MAPK Phosphatase Akt Survivin CDK mTOR Apoptosis Autophagy Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Ceramide (Egg) (Ceramide (Egg, Chicken)) is a ceramide from chicken. Ceramide (Egg) is a sphingomyelin signaling pathway second messenger. Ceramide (Egg) activates PP2A, JNK, p38 MAPK, CAPK, ceramide-activated protein phosphatase, Vav, *PKCζ, and SAPK/JNK* cascade. Ceramide (Egg) downregulates or inhibits AKT, survivin, CDK2, mTOR, and FLIP. Ceramide (Egg) mediates apoptosis, autophagy, cell cycle arrest, mitochondrial dysfunction, redox state shifts, and ROS generation. Ceramide (Egg) can be used for the research of cancer and neurological disease .

HY-N9097

Niazirin	Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase	Metabolic Disease Inflammation/Immunology
Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced *PKCζ* activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis .

HY-13689R

Go 6983 (Standard) Gö 6983 (Standard); Goe 6983 (Standard)	PKC Reference Standards	Cancer
Go 6983 (Standard) is the analytical standard of Go 6983. This product is intended for research and analytical applications. Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

HY-124308

PS315	PKC	Cancer
PS315, a derivative of PS48 (HY-15967), is an allosteric *PKC* inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKC_ζ (IC₅₀=10 μM) and PKCη (IC₅₀=30 μM). PS315 has anti-cancer activity .

HY-P1372

PKC ζ pseudosubstrate	PKC	Others
PKC ζ pseudosubstrate, a PKC ζ inhibitor peptide, can be attached to cell permeabilization vector peptide .

HY-P3201

PKCζ/ι pseudosubstrate inhibitor	Pyruvate Kinase	Neurological Disease
PKCζ/ι pseudosubstrate inhibitor has broad-spectrum effects on the *PKC* enzyme family and can induce memory impairment .

HY-E70855

PKCζ Recombinant Human Active Protein Kinase	PKC	Cancer
PKCζ is a member of the atypical PKC subfamily and has been widely implicated in the regulation of cellular functions. The major activation pathway of PKCζ depends on phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP(3)), which is mainly produced by PI-3 kinase. PKCζ Recombinant Human Active Protein Kinase is a recombinant PKCζ protein that can be used to study PKCζ-related functions .

HY-13626S

Spisulosine-d3 ES-285-d₃	Isotope-Labeled Compounds PKC Apoptosis	Cancer
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and *PKCζ* activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

Cat. No.	Product Name	Target	Research Area

HY-P3012

Cathepsin G	Cathepsin ERK p38 MAPK PKC Protease Activated Receptor (PAR) MMP	Inflammation/Immunology
Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating *PKCζ* membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases .

HY-P1372

PKC ζ pseudosubstrate	PKC	Others
PKC ζ pseudosubstrate, a PKC ζ inhibitor peptide, can be attached to cell permeabilization vector peptide .

HY-P3201

PKCζ/ι pseudosubstrate inhibitor	Pyruvate Kinase	Neurological Disease
PKCζ/ι pseudosubstrate inhibitor has broad-spectrum effects on the *PKC* enzyme family and can induce memory impairment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13626

Spisulosine ES-285	Alkaloids Animals Classification of Application Fields Other Alkaloids Marine natural products Other marine organisms Disease Research Fields Source Classification Cancer	PKC Apoptosis
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and *PKCζ* activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-N9097

Niazirin	Structural Classification Moringa oleifera Lam. Moringaceae Plants Saccharides Monosaccharides Source Classification	Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase
Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced *PKCζ* activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis .

Cat. No.	Product Name	Chemical Structure

HY-13626S

Spisulosine-d3
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and *PKCζ* activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

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PKCζ

Inhibitors & Agonists

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Isotope-Labeled Compounds

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